DOÇ. DR. AYŞE KARAKEÇİLİ    
Name : AYŞE
Surname : KARAKEÇİLİ
E-Mail : akarakecili@eng.ankara.edu.tr, aysekarakecili@yahoo.com
Phone Number : 203 34 22
Title : DOÇ. DR.
Unit : FACULTY OF ENGINEERING
Department : CHEMICAL ENGINEERING
ABS Url:https://abs.ankara.edu.tr/ayse-karakecili
Personal Information

AYŞE G. KARAKEÇİLİ, PhD

Resume

CONTACT INFORMATION:

Ankara University Chemical Engineering Dept.

Tandoğan 06100 Ankara, Turkey

+90 312 203 34 22

akarakecili@eng.ankara.edu.tr

aysekarakecili@yahoo.com


 1. EDUCATION:

PhD., Chemical Engineering, Hacettepe University, 2006

DESIGN, CHARACTERIZATION AND TISSUE ENGINEERING APPLICATIONS OF MICROPATTERNED BIOACTIVE MATERIALS

Supervisor: Prof. Menemşe Gümüşderelioğlu

 

MSc., Chemical Engineering, Hacettepe University, 1995

INVESTIGATION OF BIOFILM FORMATION MECHANISMS ON POLYMERIC SURFACES AND MATERIAL DESIGN FOR BIOMEDICAL APPLICATIONS

Supervisor: Prof. Menemşe Gümüşderelioğlu

 

BSc., Chemical Engineering, Hacettepe University

 

2.  ACADEMIC POSITIONS:

Current Position  Associate Prof., Chemical Engineering, Ankara University.

2014-2015            Visiting Researcher, Biomedical Engineering, Columbia University

2010-2013            Assistant Prof., Chemical Engineering, Ankara University.

2000-2006            Research Assistant, Chemical Engineering, Hacettepe University

2004-2005            Visiting Researcher, Universita Degli Studi di Catania,Italy.


3.  AWARDS AND FELLOWSHIPS:

2014      TÜBİTAK, Post-Doctoral Research Fellowship

2007      TÜBİTAK, Research Fellowship

2005    Consorzio Interuniversitario per i Sistemi a Grande Interfaccia (CSGI)

2004      L’OREAL-UNESCO ‘For Women in Science’ Award.


4. RESEARCH INTEREST

Biomaterials Science and Engineering

Polymer Technology 

Micro/nanofabrication Techniques

Tissue Engineering

 

5. RESEARCH EXPERIENCE: (As Project Manager only)

Smart and innovative packaging, post-harvest rot management and shipping of organic citrus fruit, PRIMA- Partnership for Research and Innovation in the Mediterranean Area' funded under HORIZON2020 the European Union's Framework Programme for Research and Innovation, 2019-continuing, Partner.

Antibiotic Loaded Chitosan/MOF Composite Tissue Scaffolds: Synthesis, Characterization and Investigation of Possible Use in Osteomyelitis Treatment Granted byTurkish Scientific Research Council (Project No: 218M324) continuing

Development of Biomimetic Gradient Scaffolds for Osteochondral Tissue Regeneration, Granted byTurkish Scientific Research Council (Project No: 116M437) 2019.

Fabrication and Characterization of Graphene Oxide Modified Nanocomposite Tissue Scaffolds Using Supercritical Carbondioxide, Granted byAnkara University BAP (Project No: 16L0443003) 2016.

Development of Infection Resistant and Bioactive Materials by Using Antimicrobial Peptides and Growth Factors, Granted byTurkish Scientific Research Council (Project No: 111M640) 2014.

Sequential Release of Growth Factors from Chitosan Scaffolds for Periodontal Tissue Engineering Applications, Granted byAnkara University BAP (Project No: 11B4343006) 2014.

Design and characterization of functionally graded tri-phase membranes prepared by salt-leaching/electrospinning for periodontal regeneration, Granted byAnkara University BAP (Project No: 13H4343003) 2014.

Investigation of Cellular Activity on Nanopatterned Chitosan Membranes via Electrospinning Turkish Scientific Research Council (Project No: 110M381) 2010.

 

6. PUBLICATIONS:

Korpayev, S., Kaygusuz, G., Şen, M., Orhan, K., Oto, Ç., Karakeçili, A., Chitosan/collagen based biomimetic osteochondral tissue constructs: A growth factor-free approach,International Journal of Biological Macromolecules (156), 681-690, 2020.Q1.

Korpayev, S., Toprak, Ö., Kaygusuz, G., Şen, M., Orhan, K., Karakeçili, A.,  Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix, Colloids and Surfaces B: Biointerfaceshttps://doi.org/10.1016/j.colsurfb.2020.1111112020.Q2

Karakeçili, A., Topuz, B., Korpayev, S., Erdek, M., Metal-organic frameworks for on demand pH controlled delivery ofvancomycin from chitosan scaffolds, Materials Science and Engineering C (105), 110098, 2019.Q1

Karakeçili, A., Korpayev, S., Dumanoğlu, H., Alizadeh, S., Synthesis of indole-3-acetic acid and indole-3-butyric acid loaded zinc oxide nanoparticles: Effects on rhizogenesis, Journal of Biotechnology (303), 8-15, 2019. Q2

Blumenfeld, N., Kang, J., Fenzl, A., Song, Z., Chung, J.J., Singh, R., Johnson, R., Karakeçili, A.,  Feranil, J.B., Rossen, N.S., Zhang, V., Jaggi, S., McCarty, B., Bessler, S., Schwartz, G.J., Grant, R., Korner, J., Kiefer, F.W., Gillette, B.M., Sia, S.K., A direct tissue-grafting approach to increasing endogenous brown fat, Scientific Reports-Nature (8:7957), 2018.Q1

Yıldırım, S., Demirtaş, T.T., Dinçer, C.A., Yıldız, N., Karakeçili, A., Preparation of polycaprolactone/graphene oxide scaffolds: A green route combining supercritical CO2 technology and porogen leaching, Journal of Supercritical Fluids (133), 156-162, 2018.Q1

Dinçer, C.A., Yıldız, N., Karakeçili, A., Aydoğan, N., Çalımlı, A., Synthesis and Characterization of Fe3O4-MPTMS PLGA nanocomposites for anticancer drug loading and release studies, Artificial Cells, Nanomedicine and Biotechnology, (45), 1408-1414, 2017. Q2

Eroğlu, A., Aydın, R.S.T, Karakeçili, A., Çalımlı, A., Fabrication and Process Optimization of PHEMA nanofibers by Response Surface Methodology, Journal of Nanoscience and Nanotechnology (16), 1-10, 2016.Q2

Aydın, R.S.T, Eroğlu, A., Karakeçili, A., Çalımlı, A., Designing Double-layered Nanofibrous Membranes as a Wound Dressing Material, Fibers and Polymers (17) 1765-1775, 2016.Q2

Gürbüz, S., Demirtaş, T.T., Yüksel, E., Karakeçili, A., Doğan, A., Gümüşderelioğlu, M., Multi-layered Functional Membranes for Periodontal Regeneration:Preparation and Characterization, Materials Letters (178), 256-259, 2016.Q1

Demirtaş, T.T., Göz, E., Karakeçili, A., Gümüşderelioğlu, M., Combined Delivery of PDGF-BB and BMP 6 for Enhanced Osteoblastic Differentiation, Journal of Materials Science:Materials in Medicine (27), 12, 2016.Q2

Yüksel, E., Karakeçili, A., Demirtaş, T.T., Gümüşderelioğlu, M., Preparation of Bioactive and Antimicrobial PLGA Membranes by Magainin II/EGF FunctionalizationInternational Journal of Biological Macromolecules (86), 162-168, 2016.Q2

Göz E., Karakeçili, A., Effect of Emulsification-Diffusion Parameters on Formation of Poly (3-hydroybutyrate-co-3-hydroxyvalerate) Particles, Artificial Cells, Nanomedicine and Biotechnology, (44), 226-234, 2016

Karakeçili, A., Messina, G. M. L., Yurtsever, M. Ç., Gümüşderelioğlu, M., Marletta, G., Impact of Selective Fibronectin Nanoconfinement on Human Dental Pulp Stem Cells, Colloids and Surfaces B: Biointerfaces (123), 1, 39-48, 2014.Q1

Yüksel, E., Karakeçili, A., Antibacterial Activity on Electrospun Poly(lactide-co-glycolide) Based Membranes via Magainin II Grafting, Materials Science and Engineering C (45), 510-518, 2014.Q1

Karakeçili, A., Arıkan, A., Preparation of Chitosan-nanohydroxyapatite Composite Scaffolds by a Supercritical CO2 Assisted Process, Polymer Composites, DOI 10.1002/pc.22253, 2012.Q1

Şimşek, M., Çapkın, M., Karakeçili, A., Gümüşderelioğlu, M., Chitosan and PCL Membranes Patterned via Electrospinning:Effect of Underlying Chemistry and Pattern Characteristics on Epithelial/Fibroblastic Cell Behavior, Journal of Biomedical Materials Research: Part A100A:3332–3343, 2012.Q1

Gümüşderelioğlu, M., Karakeçili, A., Demirtaş, T.T., Osteogenic Activities of MC3T3-E1 Cells on Heparin-immobilized Poly(caprolactone) Membranes, Journal of Bioactive and Compatible Polymers (26), 3, 257-269, 2011.Q2

Karakeçili A. G., Satriano C., Gümüşderelioğlu M., Marletta, G.,  Thermoresponsive and bioactive poly(vinyl ether)-based hydrogels synthesized by radiation copolymerization and photochemical immobilization, Radiation Physics and Chemistry  (77), 154-161, 2008.Q2

Demirtaş, T. T., Karakeçili, A. G., Gümüşderelioğlu, M., Hydroxyapatite Containing Superporous Hydrogel Composites: synthesis and in-vitro characterization, Journal of Materials Science: Materials in Medicine, (19), 729-735, 2008.Q2

Karakeçili, A. G., Gümüşderelioğlu, M., Physicochemical and Thermodynamic Aspects of Fibroblastic Attachment on RGDS-modified Chitosan Membranes, Colloids and Surfaces B: Biointerfaces, (61), 216-223, 2008.Q1

Karakeçili A. G., Satriano C., Gümüşderelioğlu M., Marletta, G.,  Enhancement of the Fibroblastic proliferation on chitosan surfaces by immobilized epidermal growth factor, Acta Biomaterialia, (4), 989-996, 2008.Q1

Karakeçili A. G., Demirtaş T. T., Satriano C., Gümüşderelioğlu M., Marletta, G., Evaluation of L929 Fibroblast Attachment and Proliferation on RGDS Immobilized Chitosan in Serum-containing/Serum-free Cultures, Journal of Bioscience and Bioengineering, (104), 69-77, 2007.Q2

Tığlı S., Karakeçili, A. G., Gümüşderelioğlu, M., In vitro Characterization of Chitosan Scaffolds: Influence of Composition and Deacetylation Degree, Journal of Materials Science: Materials in Medicine, (18), 1665-1674, 2007.Q2

Karakeçili A. G., Satriano C., Gümüşderelioğlu M., Marletta, G., Surface Characteristics of Ionically Crosslinked Chitosan Membranes, Journal of Applied Polymer Science, (106), 3884-3888, 2007.Q1

Karakeçili A. G., Satriano C., Gümüşderelioğlu M., Marletta, G., Relationship Between The Fibroblastic Behavior and Surface Properties of RGD-immobilized PCL Membranes, Journal of Materials Science: Materials in Medicine, (18), 317-319, 2007.Q2

Gümüşderelioğlu, M., Müftüoğlu, O., Karakeçili, G. A., Biomodification of Thermosensitive Copolymer of Ethylene Glycol Vinyl Ether by RGD and Insulin. Reactive and Functional Polymers, 58 (2), 149-156, 2004.Q1

Gümüşderelioğlu, M., Karakeçili, G. A., Uses of Thermoresponsive and RGD/Insulin Modified Poly(Vinyl-Ether)-Based Hydrogels in Cell Cultures. Journal of Biomaterials Science Polymer Edn., 14(3), 199-2112003.Q1

Karakeçili, G. A., Gümüşderelioğlu, M., Comparison of Bacterial Adhesion and Animal Cell Initial Adhesion on Hydrophilic/Hydrophilic Biomaterials. Journal of Biomaterials Science Polymer Edn., 13(2), 185-1962002.Q2


7.  SELECTED CONFERENCE PROCEEDINGS AND PRESENTATIONS :

World Congress on Tissue Engineering, Stem Cells and Regenerative Medicine, Chitosan/collagen II/nanohydroxyapatite composite hydrogels for osteochondral interface tissue engineering, March 2019, London, UK (oral presentation).

EMRS 2018 Spring Meeting, Preparation of Polycaprolactone/Graphene Oxide Scaffolds with Supercritical Carbon Dioxide Technology, Strasbourg, FR (oral presentation).

BIOMED 2017 22nd International Biomedical Science and Technology Syposium, Tissue Scaffold Fabrication by SCCO2 Technology, May 2017, Ankara (oral presentation).

Ulusal Kimya Müh Kongresi, Antimikrobiyal Peptid İmmobilizasyonu ile Enfeksiyona Dirençli Malzemelerin Geliştirilmesi, Ağustos 2014, İzmir (sözlü sunum).

WBC2016, World Biomaterials Congress. Dual Functional Biodegradable Membrane: A Combined Approach for Enhanced Tissue Integration and Antibacterial Properties, May 2016, Montreal, Canada (oral presentation).

ISN2A 2014, 1st International Symposium on Nanoparticles/Nanomaterials and Applications.  ‘Fabrication of Chitosan/Nanohydroxyapatite Composite Scaffolds for Tissue Engineering Applications’, January 2014, Portugal (oral presentation).

BIOMED 2011, 17th International Symposium on Biomedical Science and Technology. Cell-Material Interactions on Patterned Chitosan and PCL Surfaces. Ankara University, November 2011, Ankara (oral presentation).

ESB 2011, 24th European Conference on Biomaterials. Surface Modification of Polycaprolactone Membrane via Heparin for Osteogenic Differentiation of MC3T3-E1 Cells. Dublin, Irland, November 2011.

I. Stem Cell Course and V. Stem Cell Symposium, Hacettepe University, Ankara. June 2010.

BIOMED 2007, Physico-chemical aspects of fibroblastic adhesion on RGDS immobilized chitosan membranes. Yeditepe University, İstanbul, August 2007 (oral presentation).

ESB 2006, Relationship Between the Fibroblastic Behavior and Surface Properties of RGD-immobilized PCL Membranes   European Society For Biomaterials, September 2006, Nantes, France (oral presentation).

5th Advanced Course on Cell-Material Interactions, University of Porto, Portugal, July 2004 (poster and oral presentation).

The Leonardo Project-TO INNOEN, Ankara University, Ankara, June 2010


8. TEACHING EXPERIENCE:

ANKARA UNIVERSITY, CHEMICAL ENGINEERING DEPARTMENT and BIOMEDICAL ENGINEERING DEPARTMENT

CHE 212 FLUID MECHANICS, Supervisor

BME 321 FLUID MECHANICS, Supervisor

CHE 205 MASS and ENERGY BALANCES, Supervisor

CHE 349 BIOMATERIALS, Supervisor

KYM 312 MASS TRANSFER OPERATIONS, Supervisor