DR.ÖĞR.ÜYESİ ASLI KOÇ    
Name : ASLI
Surname : KOÇ
E-Mail : aslikoc79@gmail.com
Phone Number : 0 312 203 30 61
Title : DR.ÖĞR.ÜYESİ
Unit :
Department : Ankara University Faculty of Pharmacy Department of Biochemistry
Personal Information

EDUCATION
2004–2011 Ankara University, Faculty of  Pharmacy,  Department of Biochemistry , PhD
2002–2004 Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Master of Science
1997–2001 Hacettepe University, Faculty of Science, Biology, Bachelor of Science
1993–1997 Ankara Ayrancı High School, High School

WORK EXPERIENCE
2016 June-2016 September Witten/Herdecke University, Faculty of Health, Department of Medicine, Institute of Immunology & Experimental Oncology, Center for Biomedical Education and Research (ZBAF), AG Stem Cells, Witten/Germany, Post doctoral Researcher
2011 –  Ankara University, Faculty of  Pharmacy, Central Laboratory,  Biologist
2009–2011 Ankara University, Faculty of  Pharmacy, Department of Biochemistry, Research Asistant 


PUBLICATIONS
Koc A, ⦁ Ozkan T, ⦁ Karabay AZ, ⦁ Sunguroglu A, ⦁ Aktan F. Effect of L-carnitine on the synthesis of nitric oxide in RAW 264.7 murine macrophage cell line. ⦁ Cell Biochem Funct.  9(8):679-85, 2011.

Arzu Zeynep Karabay, Aslı Koç, Tülin Özkan, Asuman Sunguroğlu, Fügen Aktan, Zeliha Büyükbingöl. Effects of glucosamine on LPS/IFN-γ induced RAW 264.7 macrophage apoptosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2012, 65 (1) DOI: 10.1501/Tıpfak_000000802

Arzu Z. Karabay, Aslı Koç, Tülin Özkan, Zeliha Büyükbingöl, Asuman Sunguroğlu, Fügen Aktan. Effect of taurine on hydrogen peroxide production in lipopolysaccharide induced RAW 264.7 macrophage cells. FABAD J. Pharm. Sci, 33:187-192, 2008 (Accepted: 10.01.2011).

Karabay AZ, Koc A, Gurkan S,  Buyukbingol Z, Buyukbingol E. Inhibitory effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFN-γ activated RAW 264.7 macrophages. Cell Biochem Funct, 33(3): 121-7, 2015.

Karabay AZ, Koc A, Ozkan T, Hekmatshour Y, Sunguroglu A, Aktan F, Buyukbingol Z. Methylsulfonylmethane (MSM) activates JNK phosphorylation and induces apoptosis in HCT-116 colon cancer cells. International Journal of Molecular Sciences. 2016 (Under review).

PROJECTS
Interactions of β-catenin, Nucleer factor kappa B and Akirin Proteins and roles in imatinib resistance of chronic myeloid leukemia. , Researcher

Effects of MSM, chondroitin sulfate and glucosamine on apoptosis and iNOS gene methylation in LPS/IFNγ stimulated RAW 264.7 macrophage cell line. , Researcher
Effect of L-Carnitine on nitric oxide production in RAW 264.7 cell line. 
,Researcher

PRESENTATIONS
Aktan F, Karabay AZ, Koc A. Synergetic effects of L-Carnitine and α-lipoic acid on viability of HCT 116 cell line. 12th Annual World Congress insulin resistance, diabetes and cardiovascular disease, November 20-22, 2014, Los Angeles, CA, United States.
Aktan F, Koc A. L-Carnitine effects nitric oxide production in RAW 264.7 macrophage cells after LPS stimulation. LIPID MAPS Annual Meeting 2013, Impact of Lipidomics on Oxidized Lipids and Non-Alcoholic Fatty Liver Disease, May 7-8, 2013, La Jolla, CA, United States.
A. Koc, A.Z. Karabay, T. Ozkan, B. Altınok, Z. Buyukbingol, A. Sunguroglu, F. Aktan. Differences between akirin protein levels in imatinib resistant and sensitive K562 cell lines, International symposium of the German Society for Biochemistry and Molecular Biology, 3-6 Oct 2013, Frankfurt, GERMANY.
Arzu Z. Karabay, Aslı Koc, Tulin Ozkan, Asuman Sunguroglu, Zeliha Buyukbingol, Fugen Aktan. Examination of common gene targets for β-catenin and NFkB proteins in imatinib sensitive and resistant K562 cell lines. Analysis of autophagy regulation: Discussion of recent research and new technologies. 03 October 2013, London, United Kingdom.
Asli Koc, Tulin Ozkan, Arzu Z. Karabay, Asuman Sunguroglu, Zeliha Buyukbingol, Fugen Aktan. Interaction of NFkB and akirin proteins in imatinib resistant and sensitive K562 cell lines. Analysis of autophagy regulation: Discussion of recent research and new technologies 03 October 2013, London, United Kingdom.
Tülin Ozkan, Aslı Koc, Arzu Z. Karabay, Asuman Sunguroglu, Zeliha Buyukbingol, Fugen Aktan. Different expression pattern of akirin in K562r and K562s cell lines. EMBO Conference Series Intracellular RNA localization and localized Translation, Agust 7-12 2011, Barga, Italy.
Arzu Z. Karabay, Tülin Ozkan, Aslı Koc, Asuman Sunguroglu, Fügen Aktan, Zeliha Büyükbingöl. Effect of carnosine on nitirite production in LPS activated raw 264.7 macrophages. EMBO Conference Series Intracellular RNA localization and localized Translation, Agust 7-12 2011, Barga, Italy.
Fugen Aktan, Aslı Koc, Arzu Zeynep Karabay. Effects of L-carnitine in SNP induced RAW 264.7 macrophages. Human Proteome World Congress, 19-23 September 2010, Sydney.
Aslı Koc, Fugen Aktan. Effect of Poloxamer 407 on Nitric Oxide Production and Cell Viability in LPS Induced RAW 264.7 Macrophage Cell Line. 8th Annual World Congress on insulin resistance, diabetes and cardiovascular disease, 4 to 6 November 2010, Los Angeles, CA, United States.

Arzu Z. Karabay, Asli Koc, Selen Gurkan, Zeliha Buyukbingol, Erdem Buyukbingol. Effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFN-γ 
activated RAW 264.7 macrophages.  FEBS/EMBO Congress, August 30-September 2014, Paris, France.
A.Z. Karabay,  T. Ozkan,  A. Koc, A. Sunguroglu, Z. Buyukbingol. ⦁ Effects of methylsulfonylmethane on viability of HCT-116 cell line.  22nd IUBMB & 37th FEBS Congress, September 4-9 2012, Seville, Spain.
A. Koc, T. Ozkan, A.Z. Karabay, A. Sunguroğlu, F. Aktan. Effect of L-Carnitine on NF-kB Activity in lipopolysaccharide stimulated RAW264.7 macrophage cell line. 35th FEBS Congress: Molecules of Life, Jun 26-July 01 2010, Gothenburg, Sweden.
T. Ozkan, A. Karadag, B. Altinok, A.Z. Karabay, A. Koc, S. Bozkurt, S. Aydos, A. Sunguroglu. NF-kappaB activation and complex control of NOS2 gene promoter in K562 imatinib mesylate resistant CML cell line. 35th FEBS Congress: Molecules of Life, Jun 26-July 01 2010, Gothenburg, Sweden. 
A.Z. Karabay, T. Ozkan, A. Koc, A. Karadag, B. Altinok, Z. Buyukbingol, A. Sunguroglu, Effect of methylsulfonylmethane on LPS-IFN-gamma induced RAW 264.7 macrophage apoptosis. 35th FEBS Congress: Molecules of Life, Jun 26-July 01 2010, Gothenburg, Sweden. 
A.Z. Karabay, T. Ozkan, A. Koc, A. Karadag, B. Altinok, Z. Buyukbingol, A. Sunguroglu. Effect of wnt3a or lithium chloride preconditioning on nitric oxide production in RAW 264.7 macrophages and K562 leukemic cell line. 35th FEBS Congress Molecules of Life, Jun 26-July 01 2010, Gothenburg, Sweden. 
Koc A, ⦁ Karabay AZ, ⦁ Ozkan T, ⦁ Karadag A, ⦁ Sunguroglu A, ⦁ Aktan F, ⦁ Buyukbingol Z. Effect of L-carnitine on NO production in lipopolysaccharide induced RAW 264.7 cells. III. International Congress of Molecular Medicine 5 –8 May 2009, İstanbul, Turkey.
Aydos S, Ozkan T, Karabay AZ, Koc A, Karadag A, Altinok B, Sunguroglu A. Wheatgrass juice reduces nitric oxide production in LPS induced raw 264.7 cells. III. International Congress of Molecular Medicine  5 –8 May 2009, İstanbul, Turkey.
Ozkan T, Karabay AZ, Koc A, Karadag A, Aydos S, Calıskan E, Ozturk G, Ilgaz SN, Yukselen I, Sunguroglu A. Wheatgrass extract increases proliferation of RAW 264.7 macrophages induced by hydrogen peroxide (H2O2) or lipopolysaccharide (LPS). 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural  Product Research, 16-20 August 2009, Geneva, Switzerland.
Karabay AZ, Ozkan T, Koc A, Buyukbingol Z, Sunguroglu A. Effects of MSM (methylsulfonylmethane) on SNP (sodium nitroprusside) and H2O2 (hydrogen peroxide) induced RAW 264.7 macrophages. 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural  Product Research, 16-20 August 2009, Geneva, Switzerland.
Arzu Zeynep Karabay, Aslı Akıncı, Tulin Ozkan, Asuman Sunguroglu, Fugen Aktan, Zeliha Buyukbingol. Effect of methylsulfonylmethane on proliferation and nitric oxide production in LPS activated RAW 264.7 cells 34th FEBS Congress: Life's Molecular Interactions.  4 – 9 July 2009, Prague, Czech Republic.
Tulin Ozkan, Filiz Bakar, Arzu Zeynep Karabay, Aslı Akıncı, Buket Altinok, Aynur Karadag, Sena Aydos, Asuman Sunguroglu. Wheatgrass extract effects lipid peroxidation levels in human promyelocytic leukemia cell line HL-60 34th FEBS Congress: Life's Molecular Interactions. 4 – 9 July 2009, Prague, Czech Republic.
Aslı Akıncı, Arzu Karabay, Tulin Özkan, Asuman Sunguroglu, Fugen Aktan. The effect of LPS incubation periods on nitric oxide levels in RAW 264.7 macrophage cell line 34th FEBS Congress. Life's Molecular Interactions. 4 – 9 July 2009, Prague, Czech Republic.


CONGRESS
Biochemistry Congress; 29 October -1 November 2008, Kapadokya-Nevşehir 
III. International Congress of Molecular Medicine 5 –8 May 2009 Istanbul
9th International Symposium on Pharmaceutical Sciences, 23 - 26 Haziran 2009, Ankara
34th FEBS Congress. Life's Molecular Interactions. July 4 - 9, 2009, Prague, Czech Republic. 
35th FEBS Congress. Life's Molecular Interactions. June 26- July 1, 2010, Gothenburg, Sweden.
Analysis of autophagy regulation: Discussion of recent research and new technologies. 3 October 2013, London United Kingdom