PROF.DR. FÜGEN AKTAN    
Name : FÜGEN
Surname : AKTAN
E-Mail :
Phone Number : +90 312 2033055
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : Department of Biochemistry
Personal Information

 C U R R I C U L U M   V I T A E

 

 

Name in full: Fugen Aktan

 Sex: Female           

 Nationality: Turkish

 

Academic Qualifications:

 

1982: BS, in University of Ankara, Faculty of Pharmacy

1985: Master degree, in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

1991: Ph.D, in University of Ankara, Faculty of Pharmacy, Department of

Biochemistry

1993: Assistant Professor in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

1996: Associated Professor in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

              2004: Professor in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

 

Previous Employment and Status:

 

Research Assistant in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

Assistant Professor in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

Visiting Scholar in London University, Queen Mary College, Pharmacology

Department

Associated Professor in University of Ankara, Faculty of Pharmacy,

Department of Biochemistry

Visiting Scholar in Sydney  University, Faculty of Pharmacy, Department of

Herbal Medicine

 

Research Interest:

 

Calcium and NADPH-dependent enzymes, H+ consumption in the cells, constitutive and inducible system, antioxidant system, lipoprotein oxidation and the biochemical effects of some drugs on related with these system, Nitric oxide and NFkB pathway

 

Publications:

 

1.   " Oral yolla alınan C vitamininin serum immünglobulin düzeylerine etkisi. "

Erden (Aktan) F., Şimşek B. ve Nebioğlu S.,

Biyokimya Dergisi, 9(2):18-27, 1984.


2.   " Effect of vitamin C intake on whole blood plasma, leucocyte and urine ascorbic acid and urine oxalic acid levels. "

Erden (Aktan) F., Hacısalihoğlu A., Koçer Z., Şimşek B. and Nebioğlu S.,

Acta Vitaminol. Enzymol., 7(1-2):123-130, 1985.

 3.   " Ascorbic acid effect on some lipid fractions in human beings. "

Erden (Aktan) F., Gulenç S., Torun M., Koçer Z., Şimşek B. and Nebioğlu S., Acta Vitaminol. Enzymol., 7(1-2):131-138, 1985.

 

4.   " Biyokimyasal taramalara uygulanan korelasyon matriksinin hesaplanmasında kullanılan bir bilgisayar programı. "

Büyükbingöl E., Erden (Aktan) F. ve Nebioğlu S.,

Biyokimya Dergisi, 10(3):7-17, 1985.

  

5.   " C vitamininin antiaterojenik ve antikanserojen etkileri. "

      Nebioğlu S. ve Aktan F.,

Ankara Üniversitesi Eczacılık Fakültesi Yayınları, 60:20-22, 1986.

            

6.   " Bazı nonsteroidal antienflamatuvar bileşiklerin kalmoduline bağımlıcAMP-fosfodiesteraz enzimi üzerine inhibitör etkileri ve yapı-etki ilişkileri. "

Nebioğlu D., Koçer Z., Büyükbingöl E., Aktan F. ve Nebioğlu S., 

Biyokimya Dergisi, 12(1):31-39, 1987.


7.   " Vanadium effect on calmodulin dependent cAMP-phoshodiesterase, in vitro."

Aktan F., Nebioğlu D. and Nebioğlu S.,

Biyokimya Dergisi, 18(4):1-12, 1993.

            

8.   " Inhibitory effect of some new diarylamine derivatives on calmodulin activity." Nebioğlu D., Aktan F., Altuntaş G. and Göker H.,

J. Fac. Pharm. Gazi, 11:73-82, 1994.

  

9.   " Effect of vanadium compounds on calmodulin activity in experimental diabetes in rats. "

Aktan F. and Nebioglu S.,

Can. J. Physiol. Pharmacol., 72:753-758, 1994.

  

10. " Effect of glycated calmodulin on cyclic AMP- phoshodiesterase activity in diabetic rat liver. "

Aktan F. Daş Evcimen N. and Nebioğlu S.,

Biyokimya Dergisi,  21(4):1-10, 1996.

            

11. " Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessel already demaged by streptozotocin-diabetes. "

Koçak G., Aktan F., Canbolat O., Özoğul C., Elbeğ S., Yıldızoglu-Arı N. and Karasu Ç.,

Diab. Nutr. Metab. 13:308-318, 2000.

12. " Short-term gemfibrozil treatment reverses lipid profile and peroxidation but does not alter blood glucose and tissue antioxidant enzymes in chronically diabetic rats."

Ozansoy G., Akin B., Aktan F. and Karasu C.,

Mol. Cell. Biochem. 216:59-63, 2001.

  

13. " Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocin- diabetic rats. "

Hünkar T., Aktan F., Ceylan A., Karasu Ç. and The ADIC Study Group,

Cell Biochem. Funct. 20:297-302, 2002.

  

14. " In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca-ATPase activity in heart and liver of streptozotocin- diabetic rats: comparison with vitamin E. " 

The ADIC Study Group, Pekiner B., Ulusu N.N., Das-Evcimen N., Sahilli M., Aktan F., Stefek M., Stole S., Karasu Ç.

Biochim. Biophys. Acta 1588:71-78, 2002.

  

15. " Gypenosides derived from gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kB-mediated iNOS protein expression. "

Aktan F., Henness S., Roufogalis B.D., Ammit A.

Nitric Oxide 8:235-242, 2003.

  

16. " Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin- diabetic rat aorta. "

İrat A.M., Aktan F. and Ozansoy G.

J. Pharm. Pharmacolog. 55(10):1389-95, 2003.

 

17. " iNOS-mediated nitric oxide production and its regulation. "
Aktan F.
Life Sci. 75(6): 639-653, 2004.

18.  " Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium. "
Ceylan A., Karasu Ç., Aktan F., Güven C., Can B. and Ozansoy G.,
J. Gen. Physiol. Biophys., 22(4):535-547, 2003.

19. " Simvastatin treatment restores vasoconstriction and the inhibitory effect of LPC on endothelial relaxation via affecting oxidizing metabolism in diabetic rats. "
Ceylan A, Karasu C, Aktan F, Ozansoy G.
Diabetes Nutr Metab. 17(4):203-10, 2004.

20. " Phytopreventative Anti-Hyperlipidemic Effects Of Gynostemma Pentaphyllum In Rats. "
Megallia S., Aktan F., Davies N.M., Basil D. Roufogalis B.D.
J. Pharm. Pharmaceut. Sci. 8(3):507-515, 2005.

21.   " Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung. "
Ozansoy G, Guven C, Ceylan A, Can B, Aktan F, Oz E, Gonul B.
Cell Biochem. Funct. Nov-Dec;23(6):421-6, 2005.


22.  “ Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity.“
Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ.

     Planta Med. 2006 Jun;72(8):727-34. Epub 2006 May 29.