PROF.DR. TUNCAGÜL ALTUNTAŞ DİNLENÇ    
Name : TUNCAGÜL
Surname : ALTUNTAŞ DİNLENÇ
E-Mail :
Phone Number : 203 30 70
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : PHARMACEUTICAL CHEMISTRY
Personal Information

Overview:

Tunca Gul Altuntas, PhD is a Professor in the Department of Pharmaceutical Chemistry, Faculty of Pharmacy at Ankara University, Ankara, Turkey.

Dr. Altuntas received her BSc in the Pharmacy from the University of Ankara in 1985.

MSc in the Department of Pharmaceutical Chemistry, Faculty of Pharmacy at Ankara University in 1988.

PhD in Biopharmacy, Drug Metabolism Division from the King's College London, School of Medicine, University of London, UK in 1995.

Dr. Altuntaş was appointed as Assistant Professor in 1997, Associate Professor in 1998, and Professor in 2004 at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.

Professional Interests:

Drug metabolism, synthesis of drug candidates, drug analysis, HPLC, LC-MS.

 

Training:

Post doctoral fellowships:

-School of Pharmacy, King's College London, University of London, UK.

-The Wellcome Trust Foundation, London, UK.

 

Visiting Professor:

- Department of Anesthesiology, School of Medicine, University of Washington, Seattle, USA.

SELECTED  PUBLICATIONS

Altuntas  T.G.Yılmaz N.Ece A., Altanlar N., Ölgen S., (2018) In vitro antibacterial and antifungal activity and computational evaluation of novel indole derivatives containing 4-substituted piperazine moieties. Letterrs in Drug Design and Discovery15, 1079-1086., Doi: 10.2174/1570180815666180109161948.

Altuntas T. G.,  Yılmaz N., Çoban T., Ölgen S., (2017) Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties. Letterrs in Drug Design and Discovery14 (4),380-386.

Sheffels P.,  Schroeder  J. L.,  Altuntas T. G.,  Liggitt HD., Kharasch E. D., (2004) Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (Compound A) in rats. Chemical Research in Toxicology, 17, 1177-1189.

Altuntas T.G., Park S.B. and Kharasch E.D., (2004) Sulfoxidation of the cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (Compound A). Chemical Research in Toxicology, 17, 435-445.

Erk N., Altuntas T.G., (2004) Comparison of derivative spectrophotometric and liquid chromatographic methods for the determination of rofecoxib. Die Pharmazie59 (6), 453-456.

Altuntas T.G., Erk N., (2004) Liquid chromatographic determination of atorvastatin in bulk drug, tablets and human plasma. Journal of Liquid Chromatography & Related Technologies, 27 (1), 83-93.  

Altuntas T.G., Olgen S, Nebioglu D, and Akaho E., (2004) A study on the interaction between p60c-Src receptor tyrosine kinase and arylcarboxylic and arylacetic acid derivatives based on docking modes and in vitro activity. Biol. Pharm. Bull.,  27 (1), 61-65.

Kharasch E.D., Hoffer C., Altuntas T.G., Whittington D., (2004) Quinidine as a probe for the role of P-glycoprotein in the intestinal absorption and clinical effects of fentanyl. Journal of Clinical Pharmacology44, 224-233.

Altuntas T.G., Zager R.A., Kharasch E.D., (2003) Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether  (Compound A) in a human proximal tubular cell line. Toxicology and Applied Pharmacology193, 55-65.

Altuntas T.G., and Kharasch E.D., (2002) Biotransformation of L-cysteine S-conjugates and N-acetyl- L-cysteine S-conjugates of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human  kidney, in vitro: Interindividual variability in N-acetylation, N-deacetylation, and b-lyase catalyzed metabolism. Drug Metabolism and Disposition30 (2), 148-154.

Altuntas T.G., and Kharasch E.D., (2001) Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. Toxicology and Applied Pharmacology177, 85-93.

Altuntas T.G., Korkmaz F., and Nebioglu D., (2000) Determination of tetrahydrozoline hydrochloride  and fluorometholone in pharmaceutical formulations by HPLC and derivative UV spectrophotometry.   Pharmazie,  55(1), 49-52.


 SELECTED  POSTER AND ORAL PRESENTATIONS

 

Altuntas, T.G., Baydar A., Acar C., Yılmaz S., Çoban T., (2018) ‘Preparation and antioxidant activity of heterocyclic indole derivatives’. ICDDMCCP 2018 :20th International  Conference on Drug Design, Medicinal Chemistry and Clinical Pharmacy, (Oral Presentation), London-UK, 26-27 July.

Altuntas T.G., Demiray Yıldırım G.,(2018) ‘Determination of risperidone and 9-hydroxyrisperidone in human plasma by LC-MS’ . International Symposium on Pharmaceutical Sciences (ISOPS-12) ,  Ankara-Turkey, 26-29 June.

Acar, C., Altuntas, T.G., Göker, H., (2018) ‘Synthesis of some 6,7 dimethoxy quinazoline derivatives as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors’. International Symposium on Pharmaceutical Sciences (ISOPS-12) ,  Ankara-Turkey, 26-29 June.

Altuntas T.G.Baydar A., Yılmaz S., Çoban T.(2018) ‘In vitro anti-inflammatory activity of novel  5-fluoro and 5-methoxy indole-piperazine derivatives’.  International Symposium on Pharmaceutical Sciences (ISOPS-12) ,  Ankara-Turkey, 26-29 June.

Altuntaş T.G., Yılmaz Sarıaltın S., Çoban T., (2018)  ‘Antiinflammatory Activity of Indole Derivatives Containing 4-Substituted Piperazine Moieties’. International Eurasian Conference on Biological and Chemical Sciences (EurasianBiochem 2018), (Oral Presentation), Ankara-Turkey, 26-27 April.

Altuntas T.G., Baydar A.,. Kılıc-Kurt Z., (2015) ‘Synthesis of 4-N-substituted piperazine derivatives containing indole-2-carboxylic acid’.  International Symposium on Pharmaceutical Sciences (ISOPS-11) ,  Ankara-Turkey, 9-12 June.

Altuntas T.G., Yılmaz N., Coban T., Kılıc-Kurt Z., Ölgen S., (2015) ‘ Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties’ . International Symposium on Pharmaceutical Sciences (ISOPS-11), Ankara-Turkey, 9-12 June.

Altuntas T.G., Akansoy N., ( 2011) Indole Containing Heteroaryl  Piperazine Derivatives. RICT 2011 (The 47th International Conference on Medicinal Chemistry), Lyon-France, 6-8 July.

Altuntas T.G., Coban T., Sener  F.; (2010) Antioxidant activity of some amide derivatives of diclofenac as prodrugs. 9th International ISSX Meeting, İstanbul-Turkey, 4-8 September

Altuntas T.G., Akansoy  N., (2010) Synthesis of Indole Containing Heteroaryl  Piperazine Derivatives as Reverse Transcriptase Inhibitors. ICOS-18 (18th International Conference on Organic Synthesis), Bergen-Norvay, 1-6 August.

Altuntas T.G., Sheffels P.R., Schroeder J.L., Kharasch E.D., (2004) The role of cytochrome P4503A4/5 in sulfoxidation of cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether. (Published inDrug Metabolism Reviews , vol.  36). 7th International ISSX Meeting, Vancouver-Canada, 29 August-2 September.

Altuntas T.G., Zager R.A., Kharasch E.D., (2003) Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether in A human proximal tubular cell line (HK-2). (Published in Drug Metabolism Reviews, vol.  35). 12th North American ISSX Meeting, Providence-Rhode Island, USA, 12-16 October.

Altuntaş T.G., Kharasch E.D., (2003) Interindividual variability in N-acetylation, N-deacetylation, and ß-lyase-catalyzed metabolism  of   S-conjugates   of   the   sevoflurane degradation   product   fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl   ether in human kidney in vıtro7th International Symposium on Pharmaceutical Sciences (ISOPS-7), (Oral Presentation), Ankara-Turkey,  24-27 June.