PROF.DR. BİLGEHAN DOĞRU    
Name : BİLGEHAN
Surname : DOĞRU
E-Mail : bdogru@ankara.edu.tr
Phone Number : 0312 203 30 56
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : Basic Pharmaceutical Sciences Department
Personal Information
Name,surname: Bilgehan Doğru
Title: Prof. Dr.
Mail adress: University of Ankara, Faculty of Pharmacy, Department of Biochemistry, 06100, Tandoğan/Ankara, Turkey
Tel: 0312 203 30 56
E-mail: bdogru@ankara.edu.tr
 
     Education

    

Degree

Department

University, faculty/Institution

Year

B sc

 Biochemistry

Gazi University, Faculty of Pharmacy

1980

Ms C

 Biochemistry

Ankara University, Faculty of Pharmacy

1986

Ph D

 Biochemistry

Liverpool University, Faculty of Science

1993

 

   

 Academic achievenments:

Assoc. Prof. Dr.        :  1997                                  

Prof. Dr.                 :  2004

 

 

Scientific Publications

      1. Iscan, M., Dogru, B., Koçer, Z., and Nebioglu, S. Effects of  ascorbic acid supplementation on liver, lung and kidney microsomal drug metabolising enzymes of the guinea-pig. Comp. Biochem. Physiol. (1987)  87 B No 3: pp 575-580

 

      2. Pekiner B. and  Pennock J.F. : Oxidation of human red blood cells by a free radical initiator and effects of radical scavengers. Biochem. Mol. Biol. Int. (1994) 33 (6): 1159-1167.

 

      3. Pekiner, B. and Nebioglu, S. : Effect of vitamin C on copper and iron status in men and guinea pigs. J. Nutr. Sci. Vitaminol. (1994) 40: 401-410.

 

      4. Pekiner, B. and  Pennock J. F.: Use of antioxidants during preparation of  a-tocopherol liposomes. Nutr. Res. 1995 15(6) : 795-802.

 

      5. Pekiner B. and J. F. Pennock. : Fatty acids in plasma and red blood cell membranes in humans, rats, rabbits and dogs. Biochem. Mol. Biol. Int. (1995) 37: 221-229.

 

      6. Pekiner B. and Jack F. Pennock. In vitro effects of an azo compound on the haemolysis and unsaturated fatty acids of red blood cells. Clin. Chim. Acta. (1997, 263: 157-164).

 

      7. Murata T., Katagiri H., Ishihara H., Shibasaki Y., Asano T., Toyoda Y., Pekiner B., Pekiner C., Miwa I., Oka Y. Co-localisation of  glucokinase with actin filaments.  Febs Lett. (1997), 406: 109-113.

 

      8. Net Daş Evcimen, Bilgehan Pekiner, Sibel Süzen, Erdem Büyükbingöl. The inhibitory effect of benzodiazepine derivatives on the bovine lens aldolase reductase enzyme. Biochem. Mol. Biol. Int. (1998), 45:2, 381-387.

 

     9. N. Daş Evcimen, B. Doğru Pekiner, S. Nebioğlu. Ca2+-ATPase in  streptosotocin-induced diabetic rat kidneys. Diabetes and Metab.(1999), 25, 399-403.

 

      10.Bilgehan Doğru Pekiner, Nuray N. Ulusu, Net Das-Evcimen, Meral Sahilli,Fugen Aktan, Milan Stefeck, Svorad Stolc, Çimen Karasu. In vivo treatment with stobadine inhibits lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+-ATP ase actiivity in heart and liver of streptozotocin-diabetic rats: Comparison with vitamin E. BBA., 1588 (1), 71-78 (2002).

 

11. Pekiner Doğru B., Evcimen N. D., and Nebioğlu S. Determination of Ca2+ ATPase activity in streptozotocin-induced diabetic rat liver. Diab. Nutr. Metab. 15, 116-120, 2002.

 

12. Pekiner Doğru B., Faty acid composition in RBC membrane of PE and PC of  rat, rabbit, human and dog. Journal of Faculty of Pharmacy of Ankara University, Ankara Üniversitesi Eczacılık Fakültesi Dergisi 31, 169-182, 2002.

 

13. Pekiner Doğru B., Evcimen N. D., N. N. Ulusu, M. Bali, Ç. Karasu. Effects of vitamin E on microsomal calcium-ATPase activity and calcium levels in streptozotocin-induced diabetic rat kidney. Cell Biochemistry and Function 21 (2), 177-182 (2003).

 

14. Bilgehan Doğru Pekiner,  Phospholipid fatty acid composition of rat, rabbit, human and dog plasma. Journal of Faculty of Pharmacy of Ankara University, Ankara Üniversitesi Eczacılık Fakültesi Dergisi 32, 99-112, 2003.

 

 15.  Net Daş Evcimen, Nuray, N. Ulusu, Çimen Karasu, Bilgehan Doğru Pekiner.

       Adenosine triphosphatase activity of streptozotocin- induced diabetic rat brain microsomes. Effect of vitamin E.  General Physiology and Biophysics (2004), 23, 347-355.

      

     16. Pekiner Doğru B. Vitamin E as an antioxidant. Journal of Faculty of Pharmacy of Ankara University, Ankara Üniversitesi Eczacılık Fakültesi Dergisi 32, 253-267, (2003).

 

     17. Pekiner Doğru B., Evcimen N. and Nebioğlu S. Diabetes induced decrease in rat brain microsomal Ca2+-ATPase activity. Cell. Biochem. and Funct. 23, 239-243, (2005).

 

18. Meltem Dartar, Bilgehan Doğru. Permeability of latex gloves after explosure to six chemical agents. Quintesssence Int. 2007 38,9 : 537-543.

 

19. Dermiş Saadet and Doğru Bilgehan, gas chromatographic analysis of PS, PI, LPC and SPH fatty acids in red blood cell membrane of rat, rabbit, human and dog. Communications (2008), 54:2, 1-16.

 

20. Filiz BAKAR, Kenan KEVEN, Bilgehan DOGRU, Fugen AKTAN, Sehsuvar ERTURK, Acar TUZUNER, Bulent ERBAY, Serpil NEBIOGLU. LDL oxidizability and the alteration of its fatty acid content in renal transplant recipients treated with CsA/FK506.  Trans. Proc. (2009) 41(5):1630-1633. 

21. DERMİŞ Saadet, , Can Seda,  DOĞRU Bilgehan ‘’Determination of peroxide values of some fixed oils by using the mFOX method’’ Spectroscopy letters 2: an inernational journal for rapid communication 45:5 (359-363), 2012.

22. Evaluation of oxidative stress in renal transplant recipients treated with cyclosporine/tacrolimus : Role of HDL and heme oxygenase. Filiz Bakar, Fügen Aktan, Kenan Keven, Bilgehan Doğru, Acar Tuzuner, Bülent Erbay, Serpil Nebioğlu.: Turkish J. Pharm. Sci., 10 (1): 9-18, 2013. 

23. Bilgehan Doğru, Şerife Funda Işık ve Ayşegül Köroğlu. Oksidanlar, antioksidanlar ve antioksidan etkili yüksek bitkiler, Hayat sağlık, Sağlık ve Sosyal Bilimler Dergisi sayı:12 ,sayfa: 82-101, Aralık 2014.

ISSN 1209-6001

24. Bilgehan Doğru, Ayse Ceylan Hamamcıoğlu , Tugçe Yeşiltaş, ‘’An associaton between C-reactive protein and cardiovascular diseases’’ Medical Journal of Western Black Sea 1 (2017) 66-75

ISSN: 2587-0602

 

Presentations

İşcan M., Doğru B., Koçer Z., Nebioğlu S. Artan dozlarda askorbik asit alımının kobay karaciğeri mikrozomal karışık fonksiyonlu oksidazlarına etkisi (1986) 18- 21 Haziran. Biyokimya dergisi kongre özel sayısı 11 (1) s. 60.

 

İşcan M., Doğru B., Koçer Z., Nebioğlu S. Askorbik asit ve mikrozomal ilaç metabolize eden enzimler. V111. nci Türk Farmakoloji Kongresi,  Antalya , (1986)  31 Ekim - 2 Kasım. 4(1) sayfa 63. V111. nci Türk Farmakoloji Kongresi serbest bildiri özetleri

 

Doğru B., Nebioğlu S. (1987): Askorbik asidin bakır, seruloplazmin ve hematokrit düzeylerine etkisi.  VIII. nci Ulusal Biyokimya Kongresi, İzmir, (1987) 21-23 Ekim.

Vol 12 no 2, sayfa 88.


Doğru, B., Nebioğlu, S. Effects of vitamin C on whole blood ascorbic acid, Hb, serum iron, liver ferritin  and hemosiderin levels . 18 th FEBS Meeting,  Ljubljana , Yugoslavia, (1987)  June 28 - July 3. vol 58

 

Pekiner B. and Pennock J.F. Fatty acids in plasma and red blood cell membranes in humans, rats, rabbits and dogs.  4 th International Symposium on Pharmaceutical Sciences. Ankara, Turkey, (1995) June 27- 30.

 

Pekiner B. In vitro effects of a water soluble free radical initiator on red blood cell haemolysis. International Congress on Free Radicals in Health and Disease. Istanbul, Turkey, (1995)  September 6 - 10.

 

Pekiner B. and Pennock J.F. Use of antioxidants during preparation of a-tocopherol loaded liposomes.  International Congress on Free Radicals in Health and Disease. Istanbul, Turkey, (1995) September 6 - 10.

 

B. Doğru Pekiner, N. Daş Evcimen, S. Nebioğlu.,  Ca2+ ATP ase activity in streptozotocin-induced diabetic rat brain.  6 th International Symposium on Pharmaceutical Sciences ISOPS-6, June 27-29, 2000, Ankara, Turkey, p 239.

 

B. Doğru Pekiner, N. Daş Evcimen, N. N. Ulusu, Ç. Karasu. Effect of vitamin E on microsomal calcium,ATPase activity in streptozotocin-induced diabetic rat kidney. XI th meeting of the SFRRI, Free radical Biology and Medicine, vol. 33,S187,492, paris, France, July 16-20, 2002.

 

N. Daş Evcimen, N. N. Ulusu, C. Karasıu, B. Doğru Pekiner, Adenosine triphosphatase-induced diabetic rat brain microsomes. Effect of vitam,in E. 55 yh Annual meeting july 20-24, 2003.pennsylvania Convention center Philadelphia, Pennsylvania. (Clin. Chem, 49(6) A 117) 2003.

 

 

Filiz BAKAR, Fugen AKTAN, Kenan KEVEN, Bilgehan DOGRU, A. TUZUNER, Bulent ERBAY, Serpil NEBIOGLU. ‘’fatty acid composition of HDL in renal transplant recipients treated with cyclosporin/Tacrolimus. IUBMB Life 61 (3): 343-344, (2009).

 

DERMİŞ Saadet, , Can Seda,  DOĞRU Bilgehan, ‘’Spectrophotometric determination of peroxide of peroxide values of some fixed oils by the improved mFox method,  XII .nci Ulusal Spektroskopi kongresi, 18-22 Mayıs, Side, Antalya, 2011.


Kayhan Bolelli, Tuğba-Ertan Bolleli, Bilgehan Doğru, İlkay Yıldız ‘’Molecular Docking Studies of 2,5-Disubstituted Benzoxazole Derivatives as Aldose Reductase Enzyme Inhibitor’’ ITWCCST 2017 ABSTACT BOOK,  s. 163, 3 rd International Turkic World Conference on Chemical Sciences & Technologies,

ITWCCST – 2017, 10-13 September 2017, Baku / Azerbaijan


Other Academical Activities

       Oral presentations


Effect of vitamin C on iron metabolism. 1986, University of Ankara, Faculty of Pharmacy, Department of Biochemistry.

 

      Effect of vitamin C on copper metabolism. 1986, University of Ankara, Faculty of Pharmacy, Department of Biochemistry.

 

      The role of calmodulin on muscle contraction. 1987, University of Ankara, Faculty of Pharmacy, Department of Biochemistry.

 

       Protective effect of vitamin E and other antioxidants on the peroxidation of polyunsaturated fatty acids. 1990, University of Liverpool, Faculty of Science, Department of Biochemistry.

 

       Vitamin E and lipid peroksidation in blood.  1993, University of Ankara, Faculty of Pharmacy, Department of Biochemistry.

 

       Oxidation of red blood cells by a free radical initiator and effects of some antioxidants. 1993, Middle East Technical University, Department of Biology.

 

     Oxidation of red blood cell by tert-butylhydroperoxide and protective effects of antioxidants. 1996, Nagoya University, Department of  Pathobiochemistry.

 

               Post Doc Research;

Mei   Meijo Universityi, Faculty of Pharmacy, Clinical Biochemistry department, Nagoya, Japan

A research on ''Diabetic complications and the role of  supportive proteins ,1995-1996

 

Projects

Effect of vitamin E on some biochemical and immunological parameters in diabetes, 

,Ankara University Research found, 1998- 2001

 

5th  Framework Programme ‘Quality of Life and Management of Living Resources.’ 7. Chronic and Degenerative Diseases,Diabetes and Cardiovascular Disease. Chech Republic, 1999-2004

 

Effect of vitamin E on lipid peroxidation and NOlevels on macrophage cell line . Tubitak, and 

 Ankara University Scientific Research found (BAP), 2007-2008


Effect of aliskiren treatment on insuline resistance and cardiovascular disorders in rat models fed with high lipid diet,  Ankara University Scientific Research found (BAP)  2013-2015


Effect of some sulfonamide group-bearing benzoxazole derivatives on Aldose reductase activity in vitro
(2016-  )  proje no. 16B0237002

Administrative duties

6. ,7., and 9.th İnternational Pharmaceutical Symposium (ISOPS-6 , 7, and 9)  Orgainizing Commity membership (2000-2009),

 8 .th İnternational Pharmaceutical Symposium (ISOPS 8)  Scientific Committee membership  (2008-2009),

17. th National Biyochemistry Congress Organising Committee membership (2002),

 The Executive Board membership of ''The Society of Pharmaceutical Sciences of Ankara'' (FABAD)  (2000-2002),

  The Edutorial Board membership of ''The Society of Pharmaceutical Sciences of Ankara'' (FABAD) , (1998-2000),

Membership of Acreditation Study Committee of Ankara University, faculty of Pharmacy  (2002),

 Membership of Ankara Üniversity Super Student Election Committee  (1999-2004),

 The Executive Board membership of Ankara University, Faculty of Pharmacy Social Help and Cooperation  Branch,  (2001-2005),

Membership of  Educational Comittee of Ankara Üniversity, Pharmacy Faculty,
 (2004-2005),

Membership of Cigarette Strugle Institution Committee of Ankara University(2008-2009),

Membership of Actuion of Rolling Fund  Management Committee of Ankara University,

 (2000-2004),

 Vice Dean of  Ankara University, faculty of Pharmacy (2008-2009),

Training Examination membership of  Ankara Üniversity, Pharmacy Faculty,  (2008-2009),

Vice Chairmen of  'he Society of Pharmaceutical Sciences of Ankara (FABAD) ,  (2010-2014),


11. International Pharmaceutical Symposium (ISOPS-11)  Orgainizing Commity membership (2012-2015),

11. International Pharmaceutical Symposium (ISOPS-11)  Scientific Commity membership (2012-2015),

Management Committee membership of The Society of Pharmaceutical Sciences of Ankara (FABAD) (2014-2016)


Ankara University Faculty of Pharmacy Member of GEP (Enhanced Education Program) Commission (January 2016-continuing)

Scientific and professional membership

Turkish Biochemical Society

The Society of Pharmaceutical Sciences of Ankarai (FABAD) 

Fields of expertise

Lipid peroxidation, free radicals, antioxidants, İnhibition of Aldose reductase, Ca ATP ase

 

 

  Courses taught

 

Biyochemistry

 

Biyochemistry pratics

 

Basic Biyochemistry

 

Research project

 

Research project pratics

 

Area of specialization lecture

 

izolation and purification of proteins

 

Biochemical endpoints of environmental hazards

 

Column chromatography tecniques

 

Column chromatography tecniques pratics

 

Free radicals and anrioxidants