ASSOC.PROF.DR. FİLİZ BAKAR ATEŞ    
Name : FİLİZ
Surname : BAKAR ATEŞ
E-Mail : fbakar@ankara.edu.tr
Phone Number : 2033055
Title : ASSOC.PROF.DR.
Unit : FACULTY OF PHARMACY
Department : BIOCHEMISTRY
Personal Information

          Filiz Bakar , PhD

         Institution:  Ankara University Faculty of Pharmacy

I.       Education

2007-2012    : Ankara University Faculty of Pharmacy

                      Department of Biochemistry, PhD

 2004-2007    : Ankara University Faculty of Pharmacy

                      Department of Biochemistry, MSc

 2000-2004    : Ankara University Faculty of Pharmacy,Graduate


II.     Memberships of Scientific and Professional Communities

Turkish Association of Biochemistry

European Association of Cancer Research


III.     Scientific Activities

         Seminary:

LDL Oxidation and It's Clinical Results

The Structure and Function of Annexins

The Role of Annexins in Autoimmune Diseases


IV. Publications

1. Salar S, Kanca A, Bakar-Ates F, Bastan A. (2019). Repeated low doses of dexamethasone as a pretreatment for induction of parturition in Simmental cows. Turkish Journal of Veterinary and Animal Sciences. DOI: 10.3906/vet-1904-55

2.   Kilic-Kurt Z, Bakar-Ates F, Bahat M (2019). N,N?-diaryl urea derivatives: Molecular docking, molecular properties prediction and anticancer evaluation. Journal of Molecular Structure, 1193, 239-246.

3.  Ergul M, Bakar-Ates F. (2019). RO3280, A Novel PLK1 Inhibitor, Suppressed Proliferation of MCF-7 Breast Cancer Cells Through Induction of Cell Cycle Arrest at G2/M Point. Anticancer Agents Med Chem, DOI: 10.2174/1871520619666190618162828 

4.    Bakar-Ates F., Ozkan A. (2019). The combined treatment of brassinin and imatinib synergistically downregulated the expression of MMP-9 in SW480 colon cancer cells. Phytotherapy Research, Doi: 10.1002/ptr.6233

5.   Kilic-Kurt Z, Bakar-Ates F, Aka Y, Kutuk O (2019). Design, synthesis and in vitro apoptotic mechanism of novel pyrrolopyrimidine derivatives. Bioorganic Chemistry, Doi: 10.1016/j.bioorg.2018.10.060

6.   Ozmen N, Kaya-Sezginer E, Bakar-Ates F. (2018). The Cellular Uptake and Apoptotic Efficiency of Colchicine is Correlated with Down-regulation of MMP-9 mRNA Expression in SW480 Colon Cancer Cells. Anticancer Agents in Medicinal Chemistry, Doi: 10.2174/1871520618666180821102047.

7.   Karaca A, Bakar-Ates F, Ersöz Gulcelik N. (2018). Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes. Medical Principles and Practise, Doi: 10.1159/000493482.

8.   Kilic-Kurt Z, Bakar-Ates F, Karakas B, Kutuk O. (2018). Cytotoxic and apoptotic effects of novel pyrrolo[2,3-d]pyrimidine derivatives containing urea moieties on cancer cells, Anticancer Agents in Medicinal Chemistry, Doi: 10.2174/1871520618666180605082026.

9.    Hoxha S, Kaya-Sezginer E, Bakar-Ates F, Kokturk O, Toygar-Memikoğlu U, (2018). Effect of semi-rapid maxillary expansion in children with obstructive sleep apnea syndrome: 5-month follow-up study. Sleep and Breathing, Doi: 10.1007/s11325-018-1636-4.

10    Karaaslan C, Bakar-Ates F, Goker AH (2018). Antiproliferative activity of synthesized some new benzimidazole carboxamidines against MCF-7 breast carcinoma cells. Zeitschrift für Naturforschung C, 73(3-4), 137-145. 

11.  Bakar F, Kiliç Kurt Z Çaglayan MG, Ölgen S (2017). The Effects of 1,3,5-trisubstituted Indole Derivatives on Cell Growth, Apoptosis and MMP-2/9 mRNA Expression of MCF-7 Human Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry,17(5), 762-767., Doi: 10.2174/1871520616666160802115737

12.   Sengel Türk CT, Hasçiçek C, Bakar F, Simsek E (2017). Comparative Evaluation of Nimesulide-Loaded Nanoparticles for Anticancer Activity Against Breast Cancer Cells. AAPS PharmSciTech, 18(2), 393-403., Doi: 10.1208/s12249-016-0514-2 (Yayın No: 1643316)

13.   Hasçiçek C, Sengel Türk CT, Gümüstas M, Özkan SA, Bakar F, Evcimen N, Savaser A, Özkan Y (2017). Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization. Journal of Drug Delivery Science and Technology, 40, 73-82., Doi: 10.1016/j.jddst.2017.06.001 

14.  Karaca A, Omma T, Dura Deveci C, Bakar F, Dogan K, Aral Y, Ersoz Gulcelik N (2016). Neopterin and hsCRP are not correlated in gestational diabetes mellitus. Gynecological Endocrinology, 32(12), 977-981., Doi: 10.1080/09513590.2016.1193850 

15.  Bakar F, Karakaya S, Delimustafaoglu Bostanlik FG, Kilic CS (2016). Anticancer Effect of Ferulago mughlea Pesmen Apiaceae on Cancer Cell Proliferation. Iranian Journal of Pharmaceutical Research, 15(3), 501-504. 

16.  Bakar F (2016). Cucurbitacin B enhances the anticancer effect of imatinib mesylate through inhibition of MMP 2 expression in MCF 7 and SW480 tumor cell lines. Anti-Cancer Agents in Medicinal Chemistry, 16(6), 747-754. 

17.  Kilic Kurt Z, Bakar F, Olgen S (2015). Synthesis Biological and Computational Evaluation of Novel 1 3 5 Substituted Indolin 2 one Derivatives as Inhibitors of Src Tyrosine Kinase. Archiv der Pharmazie, 348(10), 715-729., Doi: 10.1002/ardp.201500109 

18.  Püsküllü MO, Karaaslan C, Bakar F, Göker AH (2015). Synthesis and potent cytotoxicity of some novel imidazopyridine derivatives against MCF 7 human breast adenocarcinoma cell line. Chemistry of Heterocyclic Compounds, 51(8), 723-733., Doi:10.1007/s10593-015-1765-7 

19.  Bakar F, Çaglayan MG, Onur F, Nebioglu S, Palabiyik IM (2015). Gold Nanoparticle Lignan Complexes Inhibited MCF 7 Cell Proliferation in vitro A Novel Conjugation for Cancer Therapy. Anti-Cancer Agents in Medicinal Chemistry, 15(3), 336- 344., Doi: 10.2174/1871520614666141202144152 

20.  Amanova A, Kendi Celebi Z, Bakar F, Caglayan MG, Keven K (2014). Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. Clinical Transplantation, 28(10), 1177-1183., Doi: 10.1111/ctr.12448 

21.  Bakar F, Unluturk U, Baskal N, Nebioglu S (2013). Annexin V Expression and Anti Annexin V Antibodies in Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 99(3), 932-937., Doi: 10.1210/jc.2013-2592 

22.  Olgen S, Bakar F, Aydin S, Nebioglu MD, Nebioglu S (2013). Synthesis of new indole 2 carboxamide and 3 acetamide derivatives and evaluation their antioxidant properties. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(1), 58-64., Doi:10.3109/14756366.2011.631183 

23.  Bakar F, Unluturk U, Baskal N, Nebioglu S (2013). Anti prothrombin antibodies in type 1 diabetes mellitus. Turkish Journal of Biochemistry, 38(4), 432-437., Doi:10.5505/tjb.2013.69188 

24.  Bakar F, Keven K, Dogru B, Aktan F, Ertürk S, Tüzüner A, Erbay B, Nebioglu S (2009). Low Density Lipoprotein Oxidizability and the Alteration of Its Fatty Acid Content in Renal Transplant Recipients Treated With Cyclosporine Tacrolimus. Transplantation Proceedings, 41(5), 1630 - 1633., Doi:10.1016/j.transproceed.2009.01.091 

25.  Bakar-Ates F, Mizrak-Kaya D. (2018). The Investigation of Relationship Between Annexin A1 Gene Expression and Inflammation in Colorectal Cancer Patients, Acta Oncologica Turcica, 51(2): 159-165, Doi: 10.5505/aot.2018.29591.  

26.  Bakar-Ates F, Ozmen N, Kaya-Sezginer E, Kurt EE. (2018). Effects of Colchicine on Cell Cycle Arrest and MMP-2 mRNA Expression in MCF 7 Breast Adenocarcinoma Cells, Turkish Bulletin of Hygiene and Experimental Biology, Doi: 10.5505/TurkHijyen.2018.22755   

27.  Bahadir Acikara O, Ergene Oz B, Bakar F, Saltan HG, Nebioglu S (2017). Evaluation of Antioxidant Activities and Phenolic Compounds of Scorzonera latifolia (Fisch. Mey.) DC. Collected from Different Geographic Origins in Turkey. Turkish Journal of Pharmaceutical Sciences, 14(2), 179-184., Doi: 10.4274/tjps.57070 

28. Karakaya S, Bakar F, Kilic CS. (2016). The effect of hippomarathrum microcarpum petrov (Apiaceae) growing in Turkey on PC3 cancer cell proliferation. J. Fac. Pharm. Ankara, 40(2), 19-25.

29.  Bakar F, Bahadir Acikara O, Ergene B, Nebioglu S, Saltan HG (2015). Antioxidant Activity and Phytochemical Screening of Some Asteraceae Plants.Turkish Journal of Pharmaceutical Sciences, 12(2), 123-132. 

30.  Hascicek C, Sengel Türk CT, Gümüstas M, Özkan SA, Bakar F, Evcimen N, Savaser A, Ozkan Y (2014). Influence of Polymer Molecular Weight on in vitro Characteristics and Cytotoxicity of Fulvestrant Loaded Nanoparticles. Current Drug Therapy, 9(4), 239-249., Doi: 10.2174/1574885510999150505171338 

31.  Bakar F, Aktan F, Keven K, Dogru B, Tüzüner A, Erbay B, Nebioglu S (2013). Evaluation of Oxidative Stress in Renal Transplant Recipients Treated with Cyclosporine Tacrolimus Role of HDL and Heme Oxygenase. Turkish Journal of Pharmaceutical Sciences, 10(1), 9-17. 

Congresses

- International Symposium on Pharmaceutical Sciences, Ankara University Faculty of Pharmacy, 13-16 June 2006, Ankara, Turkey.
- 31st FEBS Congress, Molecules in Health and Disease. June 24-29, 2006, Istanbul, Turkey.
XX. Ulusal Biyokimya Kongresi, 29 October- 1 November 2008, Kapadokya, Turkey.
- Advanced Lecture Course, Mechanisms, Consequences and Detection of Free Radical-Mediated Oxidative Protein Modifications, 15‑20 April, 2009  Antalya, Turkey.
Ankara Tıp Biyokimya Günü, Ankara University Medical School, 30 April 2009, Ankara, Turkey
III. International Congress of Molecular Medicine, 5-8 May, 2009, İstanbul, Turkey.
34th FEBS Congress. Life’s Molecular Interactions. July 04-09, 2009, Prague, Czech Republic.
Protein Analitiği Lisansüstü Yaz Okulu, 20-26 September 2009, Bodrum, Turkey
36th FEBS Congress, Biochemistry for Tomorrows Medicine. June 25-30, 2011, Torino, Italy.
12. Ulusal Tıbbi Biyoloji ve Genetik Kongresi, 27-30 October 2011, Antalya, Turkey
- 10th International Symposium of Pharmaceutical Sciences, 26-29 June 2012, Ankara, Turkey.

        Education Seminaries

   - Proteomics Workshop
Ankara University Institute of Biotechnology , June 2005, Ankara
Genomics Workshop
Ankara University Institute of Biotechnology, November 2005, Ankara, Turkey.
-Proteomics- Protein Structure and Function Workshop, with International Participation, 20-23 September, 2006, Antalya, Turkey
Protein Techniques Training Course
Ankara University Institute of Biotechnology, Proteomics Department, 1-31 Januaty 2008, Ankara, Turkey

IV.  Research Interests

Lipoprotein Oxidation
Antioxidant enzyme systems
Annexins, gene expression and functions in thrombotic pathways


V. International Conference Presentations

 

1.  Bakar, F.; Akbasli, A. C., Aktan, F., Kenan, K., Erturk, S., Tuzuner, A., Erbay, B., Nebioglu, S. Oxidative stress and susceptibility of LDL to oxidation in renal transplant recipients.  31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), Istanbul, TURKEY, June 24-29, 2006. The FEBS JOURNAL,  273(1): 160   Published: JUN 2006 

2.   Bakar, F., Aktan, F., Keven, K., Dogru, B., Tuzuner, A., Erbay, B., Nebioglu, S. Fatty acıd composition of HDL in renal transplant recipients treated with Cyclosporin/Tacrolimus.  IUBMB LIFE, 5-8 May 2009. 61(3): 343-344.  

3.   Bakar, F., Keven, K., Tuzuner, A., Erbay, B., Nebioglu, S. Heme oxygenase activity in lymphocytes of renal transplantation patients treated with Cyclosporin/Tacrolimus. 34th Congress of the Federation-of-European-Biochemical-Societies. Prague, CZECH REPUBLIC.  July 04-09, 2009. The FEBS JOURNAL, 276: 300. 

4.    Ozkan, T., Bakar, F., Karabay, A. Z., Akinci, A., Altinok, B., Karadag, A., Aydos, S., Sunguroglu. Wheatgrass extract affects lipid peroxidation levels in human promyelocytic leukemia cell line HL-60. 34th Congress of the Federation-of-European-Biochemical-Societies.Prague, CZECH REPUBLIC, July 04-09, 2009. The FEBS JOURNAL.  276: 334.

5.    Bakar, F., Unluturk, U., Agbaht, K., Baskal, N., Nebioglu, S. Annexin V protein and anti-annexin V antibodies: determination of their roles on thrombotic events occured in type I diabetes mellitus. 36th FEBS Congress of the Biochemistry for Tomorrows Medicine. Torino, ITALY. June 25-30, 2011. The FEBS JOURNAL. 278(1): 407.

6. Filiz Bakar, Uğur Ünlütürk, Nilgün Başkal, Serpil Nebioğlu. Annexin II proteins: An evaluation for type 1 diabetes mellitus. 10th International Symposium on Pharmaceutical Sciences (ISOPS-10), 26-29 June, 2012, Ankara, Turkey   

7. Bakar, F., Olgen, S., Nebioglu, S., Nebioglu, D. Study on the Designing and Antioxidant Properties of New N-H Indole-2- Carboxamide and 3-Acetamide Derivatives and Their Activation Potential on Heme Oxygenase. Molecular Modelling from Dynamical, Biomolecular and Materials Nanotechnology Perspectives, 26th-29th July 2009, Queensland, Australia.   

VI. National Conference Presentations 

1.    Bakar, F., Aktan, F., Keven, K., Doğru, B., Tüzüner, A., Erbay, B., Nebioğlu, S. Oksidatif Stres ve Böbrek Transplant Alıcılarında HDL Yağ Asiti İçeriğindeki Değişiklikler.  XX. Ulusal Biyokimya Kongresi, 29 Ekim-1 Kasım 2008, Kapadokya, Türkiye 

2.    Bakar, F., Aktan, F., Keven, K., Tuzuner, A., Erbay, B., Nebioglu, S. The Evaluation of HDL’s Oxidative State in Renal Transplant Recipients Receiving CsA/FK506. Advanced Lecture Course, Mechanisms, Consequences and Detection of Free Radical-Mediated Oxidative Protein Modifications, 15‑20 Nisan, 2009  Kemer Antalya, Turkey 

3.    Bakar, F., Karadag, A., Olgen, S., Nebioglu, S., Nebioglu, D. An evaluation for antioxidant effects of new N-H indole-2-carboxamide and 3‑acetamide derivatives on heme oxygenase activity and HL60 cells. 12.Ulusal Tıbbi Biyoloji ve Genetik Kongresi, 27-30 Ekim 2011, Antalya, Türkiye.