PROF.DR. İLKAY YILDIZ    
Name : İLKAY
Surname : YILDIZ
E-Mail : ilkayyildiz48@gmail.com
Phone Number : 203 30 69
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : PHARMACEUTICAL CHEMISTRY
Personal Information

Education :              

July 1986    :  B. Sc. Ankara University, Faculty of Pharmacy

April 1989: M. Sc. University of Ankara, Faculty of Pharmacy Department of Pharmaceutical Chemistry

 July 1995:    Ph.D. Ankara University, Faculty of Pharmacy Department of Pharmaceutical Chemistry

Promotions:      

May 1996           : Assistant Professor of Department of Pharmaceutical Chemistry

November 1998  : Associated Professor of Department of Pharmaceutical Chemistry

March 2004         : Full of Professor of Department of Pharmaceutical Chemistry

        

Postdoctoral Studies:

November 2000- February 2002 Post-doc position: `Emory University, Department of Chemistry` , Atlanta-USA (Fellowships from TUBITAK and Emory Emerson Center)

Projects: DFT studies on Taxol Biosynthesis and Molecular modelling of NMDA Antagonists (Supervisior: Prof. Dr. James P. Snyder)

 

Research Interests:  

*Computer-aided drug design (2D QSAR (Free-Wilson and Hansch analysis), 3D QSAR CoMFA and CoMSIA, HipHop, HypoGen, molecular modelling, conformational analysis, molecular dynamics)

* Computational Chemistry (Ab initio, Semiempirical, DFT)

* Antimicrobial, Antitumor, Antiviral, and Antioxidant active compounds

* Structure Analysis (IR, 1H NMR, Mass) and Synthesis of heterocyclic compounds

              .

Awards:

- Toprak Ilac, Science award, 1996.

- International Scientific Partnership Foundation Honourable Diploma, 2007.

 

Ph.D. Thesis Supervised

 Tugba ERTAN-BOLELLI, 2012, “Synthesis, Structure Elucidation, Antimicrobial Activity, and Molecular Modeling of Some New Sulfonamido Benzoxazole Derivatives”

 Sanaz ATAEI, 2018 “In Silico Design, Synthesis, Structure Elucidation and Investigation of Microbiological Effects of New Heterocyclic Compounds”

M.Sc. Thesis Supervised

Tugba ERTAN, 2005, “The Synthesis, Structure Elucidation, Antimicrobial Activity and Molecular Modeling of New 2-Phenyl/Benzylbenzoxazole Derivatives and Their Possible Metabolites”

Sanaz ATAEI, 2010, “Studies On Molecular Modelling of Some Topoisomerase I Inhibitors”

Birol DEMIR, 2010, “Agricultural drugs”

Zekeriya Duzgun, 2013 “Investigation of the affinities of paraoxonase-1 enzyme to some lipidlowering drugs by docking method” (Second Supervised)

Tubanur Ustaomer Dere, 2015 “Role and Importance of Clinical Pharmacy Inpatient Care”

 Esin Karatas, 2018 “Design, Synthesis and Enzyme Activities of Some New Heterocyclic Compounds as Topoisomerases II Inhibitors”

Other Academic Charges

  • Journal of Faculty of Pharmacy of Ankara University , Editorial Assistant (2002-2017)
  • Journal of Faculty of Pharmacy of Ankara University , Editor (2017-     )
  • ISOPS 7th International Symposium on Pharmaceutical Sciences, Social Committee
  • The 15th European Symposium on Quantitative Structure-Activity Relationships & Molecular Modelling, Organising Committee
  • WCADD, 1st Workshop on Computer Aided Drug Design & Development, Quantitative Structure-Activity Relationships (QSAR), Organising Committee
  • 6th AFMC International Medicinal Chemistry Symposium, Organising Committee
  • Ankara University, Project evaluation board membership: (16.06.2009-30.08.2012)
  • Member of the board of the Graduate School of Health Sciences of Ankara University (June 2010-June 2011)
  • Vice director of the Graduate School of Health Sciences of Ankara University (13.06.2011-16.10.2012)
  • Head of Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University (29.03.2011-29.09.2012)
  • Second International Conference On new Trends In Chemometrics and Applications, 25-28 October 2013, International Scientific Committee.
  • Second International Conference On new Trends In Chemometrics and Applications, 25-28 October 2013, Local Organising Committee.
  • Second International Conference On new Trends In Chemometrics and Applications, 25-28 October 2013, Poster Coordinators.

List of papers:  

 

International Journal Articles

 

1. Ismail YALCIN, Ilkay OREN, Esin SENER, Ahmet AKIN, Nejat UCARTURK; “The synthesis and the structure-activity relationships of some substituted benzoxazoles, oxazolo(4,5-b)pyridines, benzothiazoles and benzimidazoles as antimicrobial agents” European Journal of Medicinal Chemistry, 27: 401-406, (1992).

 

2. Esin SENER, Hulya TURGUT, Ismail YALCIN, Ilkay OREN, Lemi TURKER, Nihat CELEBI, Ahmet AKIN; “Structure-activity relationships of some antimicrobial 5-substituted-2-(3-pyridyl)benzoxazoles using quantum-chemical calculations” International Journal of  Pharmaceutics, 110: 109-115, (1994).

 

3. Esin SENER, Ismail YALCIN, Ozlem TEMIZ, Ilkay OREN, Ahmet AKIN, Nejat UCARTURK;  “Synthesis and Structure-Activity Relationships of some 2,5-disubstituted Benzoxazoles and Benzimidazoles as Antimicrobial Agents” Il Farmaco, 52(2): 99-103 (1997).

 

4. Ilkay OREN, Ozlem TEMIZ, Ismail YALCIN, Esin SENER, Ahmet AKIN, Nejat UCARTURK; “Synthesis and Microbiological Activity of 5 (or 6)-methyl-2-substituted Benzoxazole and Benzimidazole Derivatives” Arzneimittel-Forschung/Drug Research, 47(12): 1393-1397 (1997).

 

5. Ismail YALCIN, Bedia KOCYIGIT KAYMAKCIOGLU, Ilkay OREN, Esin SENER, Ozlem TEMIZ, Ahmet AKIN, Nurten ALTANLAR;  “Synthesis and Microbiological activity of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides as the possible metabolites of antimicrobial active benzoxazoles” Il Farmaco, 52(11): 685-689 (1997).

 

6. Celik TarImcI, Filiz ERCAN, Meltem KOCOGLU, Ilkay OREN; “N-[(2-Hydroxy-5-chloro)phenyl]thiophenylacetamide” Acta Crystallographica Section C,  C54: 488-489 (1998).

 

7. Ozlem TEMIZ, Ilkay OREN, Esin SENER, Ismail YALCIN, Nejat UCARTURK; “Synthesis and microbiological activity of some novel 5- or 6-methyl-2-(2,4-disubstitutedphenyl)benzoxazole derivatives” Il Farmaco53: 337-341 (1998).

 

8. Ilkay OREN, Ozlem TEMIZ, Ismail YALCIN, Esin SENER, Nurten ALTANLAR; “Synthesis and antimicrobial activity of some novel 2,5- and/or 6-substituted benzoxazole and benzimidazole derivatives” European Journal of Pharmaceutical Sciences, 7: 153-160 (1998).

 

9. Esin AKI SENER, Kamuran K. BİNGÖL, Ilkay OREN, Ozlem TEMIZ ARPACI, Ismail YALCIN, Nurten ALTANLAR; “Synthesis and microbiological activity of some N-(o-hydroxyphenyl)benzamides and phenylacetamides as the possible metabolites of antimicrobial  active benzoxazoles, Part II” Il Farmaco, 55: 469-476 (2000).

 

10. Ismail YALCIN, Ilkay OREN, Ozlem TEMIZ and Esin AKI-SENER; “QSARs of some novel isosteric heterocyclics with antifungal activity” Acta Biochimica Polonica, 47(2): 481-486 (2000).

 

11. Ozlem TEMIZ ARPACI, Ilkay OREN, Nurten ALTANLAR; “Synthesis and antimicrobial activity of some novel 2-(p-substituted-phenyl)-5-substituted-carbonylaminobenzoxazoles” Il Farmaco,  57: 175-181 (2002).

12. David C. Lankin, Gary L. Grunewald, F. Anthony Romero, Ilkay Yıldız Oren, James P. Snyder; “The NH¾FC Dipole Orientation Effect for Pendant Exocylic CH2Organic Letters, 4(21): 3557-3560 (2002).

 

13. Ayşegül AKBAY, Ilkay OREN, Ozlem TEMIZ, Esin AKI-SENER, Ismail YALCIN; “Synthesis and HIV-1 Reverse Transcriptase Inhibitor Activity of Some 2,5,6-Substituted Benzoxazole, Benzimidazole, Benzothiazole and Oxazolo(4,5-b(pyridine Derivatives” Arzneimittel-Forschung/Drug Research,  53(4): 266-271 (2003).

 

14. Ismail YALCIN, Betul B. TEKINER, Ilkay YILDIZ-OREN, Ozlem TEMIZ-ARPACI, Esin AKI-SENER, Nurten ALTANLAR; “Synthesis and antimicrobial activity of some novel 2,6,7-trisubstituted-2H-3,4-dihydro-1,4-benzoxazin-3-one derivatives” Indian Journal of Chemistry, Vol. 42B: 905-909 (2003).

 

15. Ilkay YILDIZ-OREN, Betul TEKINER-GULBAS, Ozlem TEMIZ-ARPACI, Ismail YALCIN, Esin AKI-SENER; “3D-QSAR CoMFA studies on 2-(p-substitutedbenzyl)-5-(substitutedcarbonylamino)benzoxazoles as antibacterial agents against Staphylococcus aureus” Asian Journal of Chemistry, Vol 16, Nos. 3-4, 1359-1366 (2004).

 

16. Ilkay YILDIZ-OREN, Ismail YALCIN, Esin AKI-SENER, Nejat UCARTURK; “Synthesis and structure-activity relationships of new antimicrobial active multisubstituted benzazole derivatives” European Journal of Medicinal Chemistry39, 291-298 (2004).

 

17. Ilkay YILDIZ-OREN, Esin AKI-SENER, Cengiz ERTAS, Ozlem TEMIZ-ARPACI, Ismail YALCIN, Nurten ALTANLAR; “Synthesis and microbiological activity of some substituted N-(2-hydroxy-4-nitrophenyl)benzamides and phenylacetamides as the possible metabolites of antimicrobial active benzoxazoles” Turkish Journal of Chemistry 28, 441-449 (2004)

 

18. Asli Pinar, Pinar Yurdakul , Ilkay Yildiz , Ozlem TEMIZ-Arpaci , N. Leyla Acan , Esin Aki-Sener and Ismail Yalcin” Some fused heterocyclic compounds as eukaryotic topoisomerase II inhibitors”, Biochemical and Biophysical Research Communications, Volume 317, Issue 2,  670-674 (2004).

 

19. Richard K. Plemper,   Karl J. Erlandson, Ami S. Lakdawala, Aming Sun, Andrew Prussia, Jutatip BoonsombaT, Esin Aki-Sener, Ismail Yalcin, Ilkay Yildiz, Ozlem TEMIZ-Arpaci, Betul TEKINER, Dennis Liotta, James P. Snyder, Richard W. Compans  "A Novel Target Site for Template-Based Design of Measles Virus Entry Inhibitors"  PNAS (Proceedings of the National Academy of Sciences of the United States of America)  101(15), 5628-5633 (2004).

 

20. Sun, AM; Plemper, RK; Erlandson, KJ; Lakdawala, A ; Prussia, A ; Akisener, E; Yalcin, I: Yildiz, I ; Temiz-Arpaci, O; Tekiner, B ; Liotta, DC ; Compans, RW; Snyder, JP “Inhibition of the measles virus cell entry: Fusion blockade.” 228th National Meeting of the American-Chemical-Society Location: Philadelphia, PA Date: AUG 22-26, 2004, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 228   Pages: U968-U968   Part: 1  Meeting Abstract: 333-MEDI   Published: AUG 22 2004

 

21. Ilkay YILDIZ-OREN, Betul TEKINER, Ismail YALCIN, Ozlem TEMIZ-ARPACI, Esin AKI-SENER, Nurten ALTANLAR; “Synthesis and antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles” Archiv der Pharmazie , 337(7), 402-410 (2004).

 

22.     Ozlem TEMIZ-ARPACI, Aliye ÖZDEMİR, Ismail YALCIN, Ilkay YILDIZ, Esin AKI-SENER, Nurten ALTANLAR; “Synthesis and Antimicrobial Activity of Some 5-[2-(Morpholin-4-yl)acetamido] and/or 5-[2-(4-Substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles”Arch. Pharm. Chem. Life Sci. 338, 105-111 (2005).

 

23.     Ozlem TEMIZ-ARPACI, Betul TEKINER-GULBAS, Ilkay YILDIZ, Esin AKI-SENER Ismail YALCIN, `3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method` Bioorganic and Medicinal Chemistry, 13, 6354-6359 (2005).

 

24.     Betul TEKINER-GULBAS, Ozlem TEMIZ-ARPACI, Ilkay YILDIZ, Esin AKI-SENER Ismail YALCIN, “3D-QSAR Study on Heterocyclic Topoisomerase II Inhibitors Using CoMSIA” SAR and QSAR in Environmental Research, 17 (2), 121-132 (2006).

 

25.     Ozlem TEMIZ-ARPACI, Tulay ÇOBAN, Betul TEKINER-GULBAS, Benay CAN-EKE, Ilkay Yildiz, Esin Aki-Sener, Ismail Yalcin and Mumtaz Iscan, “A Study on the Antioxidant Activities of Some New Benzazole Derivatives” Acta Biologica Hungarica, 57(2), 201-209 (2006).

 

26.     Sabiha ALPER-HAYTA, Esin AKI-SENER, Betul TEKINER-GULBAS, Ilkay YILDIZ, Ozlem TEMIZ-ARPACI, Ismail YALCIN, Nurten ALTANLAR, `Synthesis, antimicrobial activity and QSARs of new benzoxazine-3-ones.
Eur J Med Chem., 41(12), 1398-1404 (2006).

 

27.     Tugba ERTAN, Ilkay YILDIZ, Semiha OZKAN, Ozlem TEMIZ-ARPACI, Fatma Kaynak, Ismail Yalcin, Esin Akı-Sener and Ufuk Abbasoglu, `Synthesis and Biological Evaluation of New N-(2-hydroxy-4(or 5)-nitro/aminophenyl) benzamides and phenylacetamides as Antimicrobial Agents` Bioorganic and Medicinal Chemistry, 15, 2032-2044 (2007).

 

28.      PL Anto, Yohannan C. Panicker, Hema Tresa Varghese, Daizy Philip, Ozlem Temiz-Arpaci O, Betul Tekiner-Gulbas, Ilkay Yildiz., ` Vibrational spectroscopic studies and ab initio calculations of 5-methyl-2-(p-fluorophenyl)benzoxazole.` Spectrochim Acta A Mol Biomol Spectrosc., 67, 744-749 (2007).

29.     Tugba ERTAN, Ilkay YILDIZ, Semiha OZKAN, Ozlem TEMIZ-ARPACI, Fatma Kaynak, Ismail Yalcin, Esin Akı-Sener and Ufuk Abbasoglu, `Synthesis and Biological Evaluation of New N-(2-hydroxy-4(or 5)-nitro/aminophenyl) benzamides and phenylacetamides as Antimicrobial Agents` Bioorganic and Medicinal Chemistry, 15, 2032-2044 (2007).

30.     Betul Tekiner-Gulbas, Ozlem TEMIZ-ARPACI, Emine OKSUZOGLU, Hatice EROGLU, Ilkay YILDIZ, Nuran DIRIL, Esin AKI-SENER, Ismail YALCIN, QSAR of genotoxic active benzazoles` SAR and QSAR in Environmental Research, 18, 251-263 (2007). 

 

31.     Emine OKSUZOGLU, Betul TEKINER-GULBAS, Sabiha ALPER, Ozlem TEMIZ-ARPACI, Tugba ERTAN, Ilkay YILDIZ, Nuran DIRIL, Esin AKI-SENER, Ismail YALCIN, `Some benzoxazoles and benzimidazoles as DNA topoisomerase I and II inhibitors` Journal of Enzyme Inhibition and Medicinal Chemistry, 23 (1) 37-42 (2008).

 

32.     Emine OKSUZOGLU, Ozlem TEMIZ-ARPACI, Betul TEKINER-GULBAS, Hatice EROGLU, Gulseren SEN, Sabiha ALPER, Ilkay YILDIZ, Nuran DIRIL, Esin AKI-SENER, Ismail YALCIN, `A study on the genotoxic activities of some new benzazoles` Medicinal Chemistry Research, 16, 1-14(2007).

 

33.     Betul TEKINER-GULBAS, Ozlem TEMIZ-ARPACI, Ilkay YILDIZ, Nurten ALTANLAR, `Synthesis and In vitro Antimicrobial Activity of New 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles` European Journal of Medicinal Chemistry, 42, 1293-1299 (2007).

 

34.     Ilkay YILDIZ, Tugba Ertan, Kayhan Bolelli, Ozlem Temiz-Arpaci, Ismail Yalcin, and Esin Aki “QSAR and Pharmacophore Analysis on Amides Against Drug Resistant S. aureus, SAR and QSAR in Environmental Research, 19 (1-2) 101-113 (2008)

 

35.     Ozlem Temiz-Arpaci, Ilkay YILDIZ, Semiha OZKAN, Fatma KAYNAK, Ismail Yalcin, and Esin Aki-Sener, “Synthesis and biological activity of some new benzoxazoles.” Eur J Med Chem. 43(7), 1423-31 (2008) .

 

36.     AMBUJAKSHAN KR, MADHAVAN VS, VARGHESE HT, PANICKER CY, TEMIZ-ARPACI O, TEKINER-GULBAS B, YILDIZ I.” Vibrational spectroscopic studies and ab initio calculations of 5-methyl-2-(p-methylaminophenyl)benzoxazole” Spectrochim Acta A Mol Biomol Spectrosc. , 69(3), 782-8 (2008).

 

37.     Sabiha ALPER-HAYTA, Mustafa ARISOY, Özlem TEMIZ-ARPACI, Ilkay YILDIZ, Esin AKI, Semiha ÖZKAN, Fatma KAYNAK, “Synthesis, Antimicrobial Activity, Pharmacophore Analysis of Some New 2-(substitutedphenyl / benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles”, Eur J Med Chem., 43(11), 2568-78 (2008).

 

38.     Ilkay YILDIZ, Sabiha ALPER, Tugba ERTAN, Ozlem TEMIZ-ARPACI, Betul TEKINER GULBAS, Esin AKI-SENER, Ismail YALCIN ` Molecular modelling studies on some eukaruotic topoisomerase II enzyme inhibitor fused heterocyclic compounds` DRUGS OF THE FUTURE 32: 15-16 Suppl. A, JUL 2007.

 

39.     Emine Deniz (ÇALIŞIR) TEKIN, Figen ERKOÇ, İlkay YILDIZ, Şakir ERKOÇ “Quantum Chemical Calculations of Warfarin Sodium, Warfarin and Its Metabolites” Commun. Comput. Phys., 4(1), 161-176 (2008).

 

40.     MARY YS, VARGHESE HT, PANICKER CY, ERTAN T, YILDIZ I, TEMIZ-ARPACI O. “Vibrational spectroscopic studies and ab initio calculations of 5-nitro-2-(p-fluorophenyl)benzoxazole.” Spectrochim Acta A Mol Biomol Spectrosc. 15;71(2); 566-71 (2008)

 

41.     Mustafa ARISOY., Özlem TEMIZ-ARPACI, Ilkay YILDIZ, Fatma KAYNAK ONURDAĞ,  Esin AKI, İsmail YALÇIN, Ufuk ABBASOĞLU “Synthesis, antimicrobial activity and QSAR studies of 2,5-disubstitutedbenzoxazoles”, SAR and QSAR in Environmental Research, 19(5-6), 589-612 (2008).

 

42.     L. USHAKUMARI, Hema TRESA VARGHESE, C. Yohannan PANICKER, Tugba ERTAN and Ilkay. YILDIZ. “Vibrational spectroscopic studies and DFT calculations of 4-fluoro-N-(2-hydroxy-4- nitrophenyl)benzamide” Journal of Raman Spectroscopy, 39, 1832-1839 (2008).

 

43.     Tugba ERTAN, İlkay YILDIZ, Betül TEKINER-GULBAS, Kayhan BOLELLI, Ozlem TEMIZ-ARPACI, Semiha ÖZKAN, Fatma KAYNAK, İsmail YALÇIN, Esin AKI.” Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents” Eur. J Med. Chem., 44, 501-510 (2009).

 

44.      İlkay YILDIZ, Oya BOZDAG-DUNDAR., Three-dimensional common-feature hypotheses for hypoglycemic flavonyl-2,4-thiazolidinedione  derivatives” Med. Chem. Res. 19, 211-219, (2009).

 

45.     AKI, E., YALCIN, I., YILDIZ, I., TEMIZ-ARPACI, O., BOLELLI, K., ERTAN-BOLELLI, T., “DNA-Topoisomerase Inhibitory Activity of Some Heterocyclic Compounds and Their Structure-Activity Relationships”, Medicinal Chemistry Research, 19 (Suppl. 1),  S6, 2010.

46.     YALCIN, I., AKI, E., YILDIZ, I., TEMIZ-ARPACI, O., “Antimicrobial Activity and Structure-Activity Relationships of Some Synthesized Benzazoles and Their Possible Metabolites”, Medicinal Chemistry Research, 19 (Suppl. 1), S41, 2010.

47.     C. Yohannan PANİCKER, Hema TRESA VARGHESE, L. USHAKUMARİ, Tugba ERTAN, Ilkay YILDIZ, Carlos M. GRANADEİRO, Helena I.S. NOGUERİA, Y. Shyma MARY, “FT-IR, FT-Raman, SERS spectra and computational calculations of 4-ethyl-N-(2’-hydroxy-5’-nitrophenyl)benzamide” Journal of Raman Spectroscopy, 41, 381-390 (2010).

48.     Akı.  E., Yalçın. I., Yıldız., Temiz-Arpacı. O., Bolelli. K., Ertan-Bolelli. T., “DNA-Topoisomerase Inhibitory Activity of Some Heterocyclic Compounds and Their Structure-Activity Relationships”, Medicinal Chemistry Research, 19 (Suppl. 1),  S6, 2010.

 

49.     Yalçın, I., Akı, E., Yildiz, I., Temiz-Arpacı, O., “Antimicrobial Activity and Structure-Activity Relationships of Some Synthesized Benzazoles and Their Possible Metabolites”, Medicinal Chemistry Research, 19 (Suppl. 1), S41, 2010.

 

50.     Sheena, M.Y., Panicker, C.Y. ,  Vargehese, T., Raju, K., Ertan-Bolelli, T.,  Yildiz, I., Granadeiro, MC.,  Nougueira, H.I.S. “Vibrational spectroscopic studies and computational study of 4-fluoro-N-(2’-hydroxy-4’-nitrophenyl)phenylacetamide”, Journal of Molecular Structure, 994, 223-231 (2011).

 

51.     Sheena Mary, Y., Raju, K., Yildiz, I., Temiz-Arpaci, O., Nogueira, H.I.S.., Granaderiro, C.M..., Alsenoy, C.V. . “FT-IR, FT-Raman, SERS and computational study 3 of 5-ethylsulphonyl-2-(o-chlorobenzyl)benzoxazole”,  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ,  96 , 617-625 (2012).

 

52.     SHEENA MARY, Y., RAJU, K., ERTAN BOLELLİ, T., YILDIZ, I,. NOGUEİRA, H.I.S. GRANADEİRO, C.M. ALSEONY, C.V. FT-IR, FT-Raman, surface enhanced Raman scattering and computational study of 2-(p-fluorobenzyl)-6-nitrobenzoxazole”, Journal of Molecular Structure 1012, 22–30 (2012)

 

53.     Tugba TASKIN, Serap YILMAZ, Ilkay YILDIZ, Ismail YALCIN, Esin AKI, “Insight into eukaryotic topoisomerase II-inhibiting fused heterocyclic compounds in human cancer cell lines by molecular docking” SAR and QSAR in Environmental Research ,. 23( 3–4), 345–355 (2012).

 

54.     Kayhan BOLELLI, Ismail YALCIN, Tugba ERTAN-BOLELLI, Selda ÖZGEN, Fatma KAYNAK-ONURDAG, Ilkay YILDIZ, Esin AKI, “Synthesis of novel 2-[4-(4-substituttedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents” Med. Chem. Res. 21:3818-3825 (2012)

 

55.     Ozgur Karban, İlkay Yıldız, Sanaz Ataei, Metin Karabulut, Erdal Dinc, Raushan Tahiyeu, Mahmut Ozbek, Erkan Er,  High performance liquid chromotographic method for determination of azithromycin in Lyophilized form, J Anal. Bioanal Techniques, 3(7), 93, 2012.

 

56.     Sanaz Ataei, İlkay Yıldız, Ozgur Karban, Metin Karabulut, Erdal Dinc, Raushan Tahiyeu, Mahmut Ozbek, Erkan Er, Quantitative analysis of pantoprazole in Lyophilized form by using HPLC method, J Anal. Bioanal Techniques, 3(7), 102, 2012.

 

57.     Sanaz Ataei, İlkay Yıldız, Ozgur Karban, Metin Karabulut, Hakan Şimşek, Erdal Dinc, Raushan Tahiyeu, Mahmut Ozbek, Erkan Er, High performance liquid chromotographic method for determination of clarithroycin in Lyophilized form J Anal. Bioanal Techniques, 3(7),  103, 2012.

 

 

58.     BHAGYASREE, J.B., VARGHESE, H.T., PANICKER, C.Y., SAMUEL, J., VAN ALSENOY, C., BOLELLI, K., YILDIZ, I., AKI, E; Vibrational spectroscopic (FT-IR, FT-Raman, 1H NMR and UV) investigations and computational study of 5-nitro-2-(4-nitrobenzyl) benzoxazole Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 102 , pp. 99-113 (2013).

 

59.     Bhagyasree, J.B.Varghese, H.T.,Yohannan Panicker, C.Samuel, J.Van Alsenoy, C.Yilmaz, S.Yildiz, I.Aki, E. Quantum mechanical and spectroscopic (FT-IR, FT-Raman, 1H NMR and UV) investigations of 2-(p-nitrobenzyl) benzoxazole , Journal of Molecular Structure 1046 , 92-100, 2013

 

60.     Alper CAN, Ilkay YILDIZ, Gulin GUVENDIK “The determination of toxicities of sulphonylurea and phenylurea herbicides with quantitative structure–toxicity relationship (QSTR) studies”  Environmental toxicology and pharmacology  35: 369-379  ( 2013).

 

61.     Serap Yilmaz, Ismail Yalcin, Fatma Kaynak-Onurdag, Selda Ozgen, Ilkay Yildiz, Esin Aki, Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles, Croatica Chemical Acta, 86(2), 223-231, 2013.

 

62.     Esin Aki-Yalcin, Tuğba Ertan-Bolelli, Tugba Taskin-Tok, Ozum Ozturk, Sanaz Ataei, Cigdem Ozen, Ilkay Yildiz, Ismail Yalcin, Evaluation of Inhibitory Effects of Benzothiazole and 3-Amino-benzothiazolium Derivatives on DNA Topoisomerase II by Molecular Modeling Studies, SAR and QSAR in Environmental Research, 25(8), 637-649, 2014.

 

63.     Tuğba Ertan-Bolelli, Yaman Musdal, Kayhan Bolelli, Serap Yılmazi Yasemin Aksoy, Ilkay Yildiz, Esin Aki-Yalcin, Ismail Yalcin, Synthesis, Biological Evaluation of 2-Substituted-5-(4-nitrophenylsulfonamido) benzoxazoles as Human GST P1-1 Inhibitors and Description of the Binding Site Features”, ChemMedChem,9(5), 984-992, 2014.

 

64.     Serap Yilmaz, G. Altinkanat-Gelmez, Kayhan Bolelli, D. Guneser-Merdan, Ufuk Over-Hasdemir, Ilkay Yildiz, Esin Aki-Yalcin, Ismail Yalcin, Pharmacophore Generation of 2-Substituted Benzothiazoles as AdeABC Efflux Pump Inhibitors in A. baumannii, SAR and QSAR in Environmental Research, 25(7), 551-563, 2014.

 

65.     Y.S. Marry, P.J. Jojo, C. Yohannan Panicker, C. Van Alsenoy, Sanaz Ataei, Ilkay Yildiz, Quantum mechanical and spectroscopic (FT-IR, FT-Raman, 1H NMR and UV) investigations of 2-(phenoxymethyl)benzimidazole", Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 125, 12-24, 2014.

 

66.     J.B. Bhagyasree, H.T. Varghese, C. Yohannan Panicker, J. Samuel, C. Van Alsenoy, Tugba Ertan-Bolelli, Ilkay YildizQuantum mechanical and spectroscopic (FT-IR, FT-Raman, 1H NMR and UV) investigations of 5-nitro-2-phenylbenzoxazole", Journal of Molecular Structure, 1063, 16-29, 2014.

 

67.     Y.S. Marry, P.J. Jojo, C. Yohannan Panicker, C. Van Alsenoy, Sanaz Ataei, Ilkay Yildiz, Theoretical investigations on the molecular structure, vibrational spectra, HOMO–LUMO and NBO analysis of 5-chloro-2-((4-chlorophenoxy)methyl)benzimidazole", Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 122, 499-511, 2014.

 

68.     Fatma Zilifdar, Sabiha Alper-Hayta, Serap Yilmaz, Cigdem Kaplan-Ozen, Egemen Foto, Zeliha Aydogan, Ilkay Yildiz, Esin Aki-Yalcin, Ismail Yalcin, Nuran Diril, Genotoxic potentials and eukaryotic DNA topoisomerase I inhibitory effects of some benzoxazine derivatives", Med. Chem. Res., 23(1), 480-486, 2014.

 

69.     Sanaz Ataei, Serap Yılmaz, Tugba Ertan-Bolelli, Ilkay Yildiz,”Generated 3D-common feature hypotheses using the HipHop method for developing new topoisomerase I inhibitors” Archiv der Pharmazie, 348 (7), 498-507, 2015.

 

70.     Karel Nesmerak, Andre A. Toropov, Alla P. Toropova, Ilkay Yildiz, Ismail Yalcin, Marketa Brozikova, Vera Klimesova, Karel Waisser, “Prediction of retention characteristics of heterocyclic compounds” Anal. Bioanal. Chem. DOI 10.1007/s00216-015-9067-6. 2015

 

71.     Ilkay Yildiz, Oya Bozdag-Dundar, “DFT Study of 3-[2-(4-chloro-phenyl)-2-oxo-ethyl]-5-(2,4-dichloro-thiazole-5-yl-methylenyl)thiazolidine-2,4-dione as antifungal agent” International Journal of Scientific and Engineering Research, 7(1),  136-141, 2016.

 

72.     Tugba Ertan-Bolelli, Ilkay Yildiz, Selda Ozgen-Ozgacar, “Synthesis, Molecular Docking and Antimicrobial Evaluation of Novel Benzoxazole Derivatives” Med. Chem. Res. 25(4), 553-567, 2016.

 

73.     Zekeriya Düzgün, Birgül Kural, Asım Örem, Ilkay Yildiz, In silico affinities of some statins to paraoxonase 1 enzyme, The FEBS Journal, 283, 234, 2016.

 

74.      Zekeriya Düzgün, Birgül Kural, Asım Örem, Ilkay Yildiz, Homology modeling and molecular docking study of the paraoxonase 1 and its polymorphic variants QR 192 and ML 55 for non statin lipid lowering drugs, The FEBS Journal, 283, 233, 2016.

 

75.     Gözde Yalcin, Ilkay Yildiz, Molecular binding profile of protoberberinealkoloids on amyloid presursor protein cleaving enzyme 1 BACE1 as a drug candidate for Alzheimer’s diseases, The FEBS Journal, 283, 232, 2016.

 

76.     Vidya V. Menon, Egemen Foto, Y. Sheena Mary, Esin Karatas, C. Yohannan Panicker, Gozde Yalcin, Stevan Armakovic, Sanja J. Armakovic, C. Van Alsenoy, Ilkay Yildiz, Vibrational spectroscopic analysis, molecular dynamics simulations and molecular docking study of 5-nitro-2-phenoxymethyl benzimidazole, Journal of Molecular Structure, 1129, 86-97, 2017.

77.     V.V. Aswathy, Sabiha Alper-Hayta, Gözde Yalcin, Y. Sheena Mary, C. Yohannan Panicker, P.J.. Jojo, Fatma Kaynak-Onurdag, Stevan Armakovic, Sanja J. Armakovic, Ilkay Yildiz, C. Van Alsenoy, Modification of benzoxazole derivative by bromine-spectroscopic, antibacterial and reactivity study using experimental and theoretical procedures, Journal of Molecular Structure, 1141, 495-511, 2017.

 

78.     Emine Oksuzoglu, Tugba Ertan Bolelli, Hatice Can, Mehtap Tarhan, Kamile Ozturk, İlkay Yıldız, Antitumor activities against  HL-60 (Human Leukemia) cells, molecular docking and quantum-chemical calculations of some sulfonamide-benzoxazoles, Artificial Cells, Nanomedicine and Biotechnology, 45(7), 1388-1396, 2017.  (http://dx.doi.org/10.1080/21691401.2016.1241796),

 

79.     Karel Nesmerak, Andrea A. Toropov, Alla P. Toropova, Tugba Ertan-Bolelli, Ilkay Yildiz, QSAR of antimycobacterial activity of benzoxaoles by optimal SMILES-based descriptors, Med. Chem. Res. 26(12), 3203-3208, 2017.

 

80.     Tugba Ertan-Bolelli, Kayhan Bolelli, Yaman Musdal, Ilkay Yildiz, Esin Akı-Yalcin, B. Mannervik, Ismail Yalcin, Design and Synthesis of 2-substituted-5-(4-trifluoromethylphenylsulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors, Artificial Cells, Nanomedicine and Biotechnology, https://doi.org/10.1080/21691401.2017.1324464, 2018 (Article in press)

 

81.     Karel Nesmerak, Karel Kudlacek, Martin Sticha, Vaclav Cerveny, Jana Kunesova, Ilkay Yildiz, HPLC-MS analysis of ipecacuanha alkaloids in pharmaceutical relics from eighteenth century, Monatschefte für Chemie-Chemical Montly, 149:1535-1542, 2018.

 

82.     Gozde Yalcin, Serdar Burmaoglu, Ilkay Yildiz, Oztekin Algul, Molecular docking studies on fluoro-substituted chalcones as potential DprE1 enzyme inhibitors, Jourmal of Molecular Structure, 1164, 50-56, 2018. Doi: 10.1016/j.molstruc.2018.02.087.

 

  1. Fatma Zilifdar, Egemen Foto, Tuğba Ertan Bolelli, Ilkay Yildiz, Esin Aki-Yalcin, Nuran Diril, Inhibition of DNA Topoisomerases by a series of benzoxazoles and their possible metabolites, Letters in Drug Design  Discovery, 15, .. , 2018 DOI:10.2174/1570180815666180124143246 (in press)

 

 

National Journal Articles

 

84. İsmail YALÇIN, Esin ŞENER, İlkay ÖREN; “QSAR of Some Antibacterial Active Isosteric Heterocyclic Compounds Against An Enterobacter” Trends in QSAR and Molecular Modelling 92, C.G. Wermuth (Ed.), Escom, Leiden, pp: 570-572 (1993).

 

85. İsmail YALÇIN, Esin ŞENER, İlkay ÖREN, Özlem TEMİZ; “Determination of the Activity Contrubutions of Some Novel Isosteric Heterocyclics Against an Enteric Gram-Negative Rod Using the Free-Wilson Analysis” QSAR and Molecular Modelling, Concepts: Computational Tools and Biological Applications, F. Sanz, J. Giraldo and F. Manaut (Eds.), Prous Science Publishers, pp: 147-151, (1995).

 

86. Esin ŞENER, Özlem TEMİZ, İlkay ÖREN, İsmail YALÇIN, Ahmet AKIN, Nejat UÇARTÜRK; “Synthesis, Antibacterial Activity and QSAR's of some 5-Substituted-2-(p-Substitutedbenzyl)benzoxazoles using the Free-Wilson Analysis” Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 24 (1): 10-20, (1995).

 

87. İlkay ÖREN; “QSAR of some antifungal active benzoxazoles and benzimidazoles against C. albicans” Ankara Üniversitesi Eczacılık Fakültesi Dergisi 27(1): 1-9 (1998).

 

88. Asriye MOCAN, Filiz KUNTAY, Funda TUĞCU, İlkay ÖREN; “Oral Cerrahi Girisimlerde Intaranazal Midazolam Uygulanmasi” Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi, 27(3): 291-296 (2000).

 

89. İlkay ÖREN, Özlem TEMİZ ARPACI, İsmail YALÇIN, Esin Aki ŞENER; “QSAR`s of some novel benzoxazole, benzimidazole and oxazolo(4,5-b)pyridine derivatives against C.albicans” Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 31 (1): 21-32 (2002).

 

90.  Özlem TEMİZ ARPACI, İlkay ÖREN, Esin Akı ŞENER, İsmail YALÇIN, Betül TEKİNER; “QSAR`s of some antibacterial active benzoxazoles against B.subtilis” Ankara Üniversitesi Eczacilik Fakultesi Dergisi, 31 (2): 73-82 (2002).

 

91. İlkay YILDIZ-ÖREN and Betül P. TEKİNER-GÜLBAŞ; “DFT Calculations of some antimicrobial active 3,4-dihydro-1,4-benzoxazin-3-one derivatives” Ankara Üniversitesi Eczacilik Fakultesi Dergisi, 32 (3): 165-173 (2003).

 

92. Ayşegül Akbay Yarpuzlu, İlkay YILDIZ, Özlem TEMİZ ARPACI, Nedim KARAGENÇ, Esin AKI ŞENER, İsmail YALÇIN; “Adenosine deaminase inhibitor activity of some benzoxazole, benzimidazole, and oxazolo(4,5-b)pyridine derivatives” XIII. Biyoteknoloji Kongresi, Bildiriler Kitabı, Çanakkale, pp: 21-26 (2003).

 

93. Özlem TEMİZ-ARPACI, Betul TEKINER-GULBAS, İlkay YILDIZ, Esin AKI-ŞENER Ismail YALCIN, `3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method` QSAR and Molecular Modelling in Rational Design of Bioactive Molecules, Proceedings of the European Symposium on Structure-Activity Relationships (QSAR) and Molecular Modelling, 15th, Istanbul, Turkey, Sept. 5-10, 2004  (2006).

94. Uğur Şenel, Tuğba Ertan Bolelli, Kayhan Bolelli, İlkay Yıldız, Enoil-açil taşıyıcı protein (ACP) redüktaz enzim inhibitörleri üzerinde yapılan doking çalışmaları (Docking Studies on Enoyl-acyl carrier protein (ACP) reductase enzyme inhibitors) , Ankara Üniversitesi Eczacılık Fakültesi Dergisi (Journal of Faculty of Pharmacy of Ankara University, 40(1), 25-35, 2016.

 

Reviews

 

95. İlkay ÖREN, İsmail YALÇIN ; “Yeni Bir Antibiyotik, Kalsimisin” Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 21(1-2): 53-65 (1992).

 

96. İlkay ÖREN, İsmail YALÇIN ; “Kemoterapötik Etkili Benzoxazole Türevleri ve Halka Analogları Üzerinde Gerçekleştirilmiş Yapı-Etki İlişkileri” Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 25: 81-106 (1996).

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