PROF.DR. GÜLGÜN KILCIGİL    
Name : GÜLGÜN
Surname : KILCIGİL
E-Mail : gkilcigil@gmail.com
Phone Number : 203 30 72
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : PHARMACEUTICAL CHEMISTRY
Personal Information

 

     Personal Information 

                                   

Prof. Dr. Gülgün Ayhan-Kılcıgil

E-posta: kilcigil@pharmacy.ankara.edu.tr

Tel: +90312 203 3072

 

Education

 

1985- BS-Ankara University Faculty of Pharmacy

1988-MS-The Graduate School of Health Sciences of Ankara University Department of Pharmaceutical Chemistry

1995- PhD- The Graduate School of Health Sciences of Ankara University Department of Pharmaceutical Chemistry

 

Professional Experience

1985-1996-Research Assistant,

1996-1999-Assistant Professor,

1999-2006-Asssociate Professor, 

2006-present- Professor

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry

 

 

Publication List

 

Research Articles

 

1.   Göker, H., Gümüş, F., Ayhan, G., Özden, T., Özden, S., Studies on Spasmolytic Activity of Some Benzimidazole Derivatives, Acta Pharmaceutica Turcica, XXXI, 53-56, 1989.

2.   Ertan, R., Ayhan, G., Yeni Bazı Antifungal Bileşiklerin Sentezleri Üzerinde Çalışmalar I, Fabad J. Pharm.Sci., 15 (1), 1-11, 1990.

3.   Ertan, R., Ayhan, G., Yuluğ, N., Rolland, Y., Synthesis and Antifungal Activities of Some New Triazolylacetophenone Derivatives, Arzneim.-Forsch./Drug Res., 45(I), 5, 620-623, 1995.

4.   Göker, H., Ayhan, G., Tunçbilek, M., Ertan, R., Leoncini, G., Garzoglio, R., Mazzei, M., Synthesis and Antiaggregator Activity of Some New Derivatives of 4H-1-benzopyran-4-one, Eur. J. Med. Chem., 30, 561-567, 1995.

5.   Kuş, C., Göker, H., Ayhan, G., Ertan, R., Altanlar, N., Akın, A., Synthesis and Antimicrobial Activity of Some New Piperidinyl Benzimidazoles,  Il Farmaco, 51(6), 413-417, 1996.

6.   Göker, H., Tunçbilek, M.,  Ayhan, G., Altanlar, N., Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity, Il Farmaco, 53, 415-420, 1998.

7.   Ayhan-Kılcıgil, G., Ertan, R.,  Özbey, S., Kendi, E., Studies on the Synthesis of Some Dihydropyridine Derivatives Possessing Calcium Antagonistic Activity,  J. Heterocyclic Chem., 35, 1485-1492, 1998.

8.   Ayhan-Kılcıgil, G., Bozdağ, O., Tunçbilek, M., Altanlar, N., Ertan, R., Synthesis and antimicrobial activity of flavone-6-carboxaldehyde oxime ether derivatives, Pharmazie, 54, 228-229, 1999.

9.   Bozdağ, O., Tunçbilek, M., Ayhan-Kılcıgil, G., Ertan, R., Studies on the synthesis of some substituted flavonyl thiazolidinedione derivatives, II, Pharmazie, 54, 151-152, 1999.

10. Özbey, S., Kendi, E., Ayhan-Kılcıgil, G., Ertan, R., (1999)  A flavone 1,4-dihydropyridine calcium antagonist, Acta Cryst. , C55, 678-680, 1999.  

11. Tunçbilek, M., Bozdağ, O., Ayhan-Kılcıgil, G., Altanlar, N., Büyükbingöl, E., Ertan, R., Synthesis and Antimicrobial Activity of Some New Flavonyl Oxime Ether Derivatives, Arzneim.-Forsch/ Drug Res. 49(II), 10, 853-857, 1999.  

12. Tozkoparan, B., Ayhan-Kılcıgil, G., Ertan, R., Ertan, M., Kelicen, P., Demirdamar, R.,  Synthesis and Evaluation of Antiinflammatory Activity of the Thiazolo [3,2-b]-1,2,4-Triazole-5(6H)-Ones and Their Michael Addition Products, Arzneim.-Forsch/ Drug Res. 49(II), 12, 1006-1011, 1999.  

13. Ayhan-Kılcıgil, G., Tunçbilek, M., Altanlar, N., Göker, H., Synthesis and antimicrobial activity of some new benzimidazole carboxylates and carboxamides, Il Farmaco, 54, 562-565, 1999.

14. Göker,H., Ayhan-Kılcıgil,G., Tunçbilek,M., Kuş,C., Ertan,R., Kendi,E., Özbey,S., Fort,M., Garcia,C., Farre,A.J., Synthesis and Antihistaminic H1 Activity of 1,2,5(6)-trisubstituted Benzimidazoles, Heterocycles, 51, 11, 2561-2573, 1999.  

15. Bozdağ, O., Ayhan-Kılcıgil, G., Tunçbilek, M., Ertan, R., Studies on the Synthesis of Some Substituted Flavonyl Thiazolidinedione Derivatives-I,  Turk J Chem, 23, 163-169 , 1999.

16. Ayhan-Kılcıgil, G., Tunçbilek, M., Ertan,R., Erol,K., Yıldırım,E., Synthesis of a new Dihydropyridine Derivative Containing a known Vasodilator Khellin, Turk J Chem, 24, 255-259, 2000.  

17. Ayhan-Kılcıgil, G., Altanlar, N., Synthesis of 3-Substituted Phenacyl-5-[2-phenyl-4H-4-oxo-1-benzopyran-6-yl)methylenyl]-thiazolidine-2,4-diones and Evaluation of Their Antimicrobial Activity, Arzneim.-Forsch/Drug Res.50(I),2, 154-157, 2000.   

18. Tunçbilek,M., Ayhan-Kılcıgil,G., Ertan,R., Can-Eke,B., İşcan,M., Synthesis and Antioxidant properties of Some New Flavone Derivatives on Lipid Peroxidation in the Rat Liver, Pharmazie, 55, 359-361, 2000.   

19.  Ayhan-Kılcıgil, G., Bozdağ-Dündar, O., Ertan, R., Altanlar,N., Synthesis and Antimicrobial Testing of Some Flavonylsulfonamide Derivatives,  Turk J Chem, 27, 461-465, 2003.   

20. Tunçbilek,M., Bozdağ-Dündar, O., Ayhan-Kılcıgil,G., Ceylan,M., Waheed,A., Verspohl,E.J., Ertan,R., Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives-fifth communication:flavonyl benzyl substituted 2,4-thiazolidinediones, Il Farmaco, 58, 79-83, 2003.  

21. Ayhan-Kılcıgil,G., Altanlar,N., Synthesis and antimicrobial activities of some new benzimidazole derivatives, Il Farmaco, 58, 1345-1350, 2003.  

22. Kuş, C., Ayhan-Kılcıgil, G., Altanlar, N., Antimicrobial Activity of Some Thiadiazolyl- and Triazolylbenzimidazoles, J.Fac.Pharm.Ankara, 33(1), 1-6, 2004.

23. Kuş,C., Ayhan-Kılcıgil,G., Can-Eke,B., İşcan,M., Synthesis and Antioxidant Properties of Some Novel Benzimidazole Derivatives on Lipid Peroxidation in the Rat Liver, Arch.Pharm.Res., 27(2), 156-163 , 2004. 

24. Ayhan-Kılcıgil,G., Kuş,C., Çoban,T., Can-Eke,B., İşcan,M., Synthesis and Antioxidant Properties of Novel Benzimidazole derivatives, J Enzym Inhib Med Ch, 19(2), 129-135 , 2004. 

25. Tunçbilek,M., Can-Eke,B., Ayhan-Kılcıgil,G., Çoban,T., İşcan,M., Evaluation of the Antioxidant Effects of Some Flavonylthiazolidinediones by Determining Their Effects on Lipid Peroxidation, Superoxide Anion Formation, and 2,2-Diphenyl-1-picrylhydrazyl Stable Free Radical, Biol.Pharm.Bull., 27(6), 912-915 , 2004. 

26.  Ayhan-Kılcıgil, G., Çoban,T., Tunçbilek, M., Can-Eke, B., Bozdağ-Dündar, O., Iscan, M. Antioxidant Properties of Flavone-6(4’)-Carboxaldehyde Oxime Ether Derivatives, Arch.Pharm Res.,27(6), 610-614 , 2004. 

27. Ayhan-Kılcıgil, G., Kuş,C., Altanlar, N., Özbey,S.,  Synthesis and Antimicrobial Evaluation of Some New 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazoles , Turk J Chem, 29, 153-162, 2005.

28. Özbey, S., Akbaş, A., Ayhan-Kılcıgil,G., Ertan,R., Antibacterial 4-amino-N-(5-methyl-isoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl] benzenesulphonamide, Acta Crystallographica Section C Crystal Structure Communications, C61,o559-561, 2005.

29. Ayhan-Kılcıgil, G., Kuş, C., Çoban, T., Can-Eke,B.,  Özbey, S., Iscan, M., Synthesis, Antioxidant and Radical Scavenging Activities of Novel Benzimidazoles, J Enzym Inhib Med Ch, 20(5), 503-514, 2005.

30. Ayhan-Kılcıgil, G., Altanlar, N., Synthesis and Antifungal Properties of Some Benzimidazole Derivatives, Turk J Chem , 30,  223-228, 2006.

31.  Kılcıgıl G., Kus C., Özdamar, ED., Eke B., Iscan M., Synthesis and Antioxidant Capacities of Some New Benzimidazole Derivatives, Arc Pharm, 340(11), 607-611, 2007.

32.  Kerimov, I., Kılcıgıl G., Eke B.,Altanlar N., Iscan M.,Synthesis antifungal and antioxidant screening of some novel benzimidazole derivatives,  J Enzym Inhib Med Ch, 22(6), 696-701, 2007.

33. Kus C., Kılcıgıl G., Özbey S., Kaynak FB., Kaya M., Çoban T., Eke B., Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class, Bioorgan Med Chem, 16(8), 4294-4303, 2008.

34. Kus C., Ayhan-Kilcigil G., Tuncbilek M., Altanlar N., Coban T., Can-Eke B., Iscan M., Synthesis Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives. Letters In Drug Design & Discovery, 6(5), 374-379, 2009.

35. Kerimov I., Kılcıgıl G., Özdamar Ed., Eke B., Çoban T., Özbey S., Kazak C., Design one pot and microwave assistedsynthesis of 2-amino/5-aryl-1,3,4-oxadiazoles bearing benzimidazole moiety as antioxidant. Arc Pharm, 345(7), 549-556, 2012.

36. Kılcıgil G., Alp AS., Çoban T., Özdamar ED., Eke B., Synthesis and Evaluation of Antioxidant Properties of Some 2 2 4 chlorophenyl benzimidazol 1 yl-N 4 oxo 2 substitutedphenyl thiazolidin 3 yl acetamides I. Chem Biol Drug Des, 76, 869-877, 2012.

37. Göker H., Coşkun M., Ayhan-Kılcıgil G (Book Chapter), Chromatographic separation and identification of a sildenafil and yohimbine analogues illegally added in herbal supplements, 51-58, 2012 (InTechPress).

38. Ayhan-Kilcigil G., Kus C., Çoban T., Özdamar ED., Can-Eke B., Identification of a Novel Series of N-Phenyl-5-[(2-phenylbenzimidazol-1-yl)methyl]-1,3,4-oxadiazol-2-amines as Potent Antioxidants and Radical Scavengers.,  Arc Pharm, 347(4), 276-282, 2014.

39. Alp AS, Kılcıgıl G., Özdamar ED., Eke B.,  Synthesis and evaluation of antioxidant activities of novel 1 3 4 oxadiazole and imine containing 1H-benzimidazoles. Turk J Chem, 39, 42-53, 2015.

40. Karayel A., Özbey S., Kılcıgil G., Kus C., Crystal structures and intermolecular interactions of two novel antioxidant triazolyl benzimidazole compounds, Crystallogr Rep, 60(7), 1084-1088, 2015.

41. Demirel S., Ayhan Kılcıgil G.,  Kara Z.,Güven B.,Onay-Beşikçi A., Synthesis and Pharmacological Evaluation of Some Benzimidazole Acetohydrazide Derivatives as EGFR Inhibitors, Turk J Pharm Sci., 14 (3), 285-289, 2017.

 

 

Review Articles

 

1.    Özden, S., Ayhan, G., İmidazol Türevi Yeni Antifungal İlaçlar, Eczacılıkta Yenilikler, A.Ü. Eczacılık Fakültesi Yayınları, 60, 136-144, 1986.

2.    Ertan, R., Ayhan, G., Angiotensin Converting Enzim İnhibitörleri,  İlsan-İltaş Yayınları, 3-40, 1993.

3.    Özkal, N., Atasü, E., Ertan, R., Ayhan, G., Some Therapeutic Effects of Flavonoids: Antispasmodic, Antihepatotoxic, Vasoprotective Effects, Fabad J. Pharm.Sci., 22, 155-161, 1996.  

4.    Ertan, R., Tunçbilek, M., Ayhan-Kılcıgil, G., 1,4-Dihidropiridin Türevi Kalsiyum Kanal Blokörleri I. (Kardiovasküler Etkileri, Yapı-Etki İlişkileri ve Biyotransformasyonları),  Türk Hij. Den. Biyol.Derg. C54-55, 41-60, 1997.

5.    Ertan, R., Ayhan-Kılcıgil, G., Tunçbilek, M., 1,4-Dihidropiridin Türevi Kalsiyum Kanal Blokörleri II (Kimyasal Yapı ve Özellikleri),   Türk Hij. Den. Biyol.Derg. C55, 55-72, 1998.

 

Book Chapter

1. H. Göker, M. Coşkun. G:Ayhan-Kilcigil,  Chromatography and its applications  Section 3 : Chromatographic seperation of Sildenafil and Yohimbine Analogues Illegally Added  in Herbal Supplements, 2012 , 51-68  (Intech Press)