DOÇ.DR. MEHMET ALP    
Adı : MEHMET
Soyadı : ALP
E-posta :
Tel : 0 (312) 2033080
Ünvan : DOÇ.DR.
Birim : ECZACILIK FAKÜLTESİ
Bölüm : Farmasötik Kimya
Kişisel Akademik Bilgiler

Eğitim

1998     Lisans, Ankara Üniversitesi, Eczacılık Fakültesi, Ankara.

2001     Yüksek Lisans, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya        

            Anabilim Dalı, Ankara.

2007     Doktora, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim     

            Dalı, Ankara.

2013     Doçent, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim     

            Dalı, Ankara

Mesleki Deneyim

1999-2005 Araştırma Görevlisi, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik     

                 Kimya Anabilim Dalı, Ankara.

2005-2015 Uzman, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya  

                 Anabilim Dalı, Ankara.

2015-         Doçent, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya  

                 Anabilim Dalı, Ankara.

Ödüller

1. 2005-2007 Novartis Farmasötik ve Medisinal Kimya İlaç Tasarım ve Geliştirme Araştırma Ödülleri, Birincilik.

2. 2009-2010 Novartis Farmasötik ve Medisinal Kimya İlaç Tasarım ve Geliştirme Araştırma Ödülleri, İkincilik.

Eserler

A. Uluslararası hakemli dergilerde yayımlanan makaleler :

A1. Hakan Göker, Mehmet Alp, Sulhiye Yıldız, "Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines", Molecules (ISI), 10; 1377-1386 pp., 2005, DOI: 10.3390/10111377

A2. Zeynep Ates-Alagöz, Mehmet Alp, Canan Kus, Sulhiye Yıldız, Erdem Buyukbingol,Hakan Göker, "Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles", Archiv der Pharmazie, Chemistry in Life Science (ISI), 339; 74-80 pp., 2006, DOI: 10.1002/ardp.200500168

A3. F.Betül Kaynak, Süheyla Özbey, Meral Tuncbilek, Mehmet Alp, "Synthesis and crystal structure of 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole", Structural Chemistry (ISI), 19; 477-480 pp., 2008, DOI: 10.1007/s11224-008-9306-y

A4. Mehmet Alp, Hakan Göker, Reto Brun, Sulhiye Yıldız., "Synthesis and antiparasitic and antifungal evaluation of 20’-arylsubstituted-1H,1’H-[2,5’]bisbenzimidazolyl-5-carboxamidines", European Journal of Medicinal Chemistry (ISI), 44; 2002-2008 pp., 2009, DOI: 10.1016/j.ejmech.2008.10.003

A5. Hakan Göker, Mehmet Alp, Zeynep Ateş-Alagöz, Sulhiye Yıldız, "Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles", Journal of Heterocyclic Chemistry (ISI), 46; 936-948 pp., 2009, DOI: 10.1002/jhet.179

A6. Hakan Göker, Maksut Coşkun, Mehmet Alp, "Isolation and identification of a new acetildenafil analogue used to adulterate a dietary supplement: dimethylacetildenafil", Turkish Journal of Chemistry (ISI), 34; 157-163 pp., 2010 , DOI: 10.3906/kim-1002-25

A7. Hacer Karataş, Mehmet Alp, Sulhiye Yıldız, Hakan Göker., "Synthesis and Potent In vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents", Chemical Biology & Drug Design (ISI), 80; 237-244 pp., 2012 , DOI: 10.1111/j.1747-0285.2012.01393.x

A.8 Mehmet Alp, Maksut Coşkun, Hakan Göker, "Isolation and identification of a new sildenafil analogue adulterated in energy drink: propoxyphenyl sildenafil", Journal of Pharmaceutical and Biomedical Analysis (ISI), 72; 155-158 pp., 2013, DOI: 10.1016/j.jpba.2012.09.017

A.9 Mehmet Alp, Hakan Göker, Tulin Ozkan, Asuman Sunguroglu, “Synthesis and cytotoxic evaluation of novel N-substituted amidino-1-hydroxybenzimidazole derivatives” Archives of Pharmacal Research (ISI), 37, 580-587pp., 2014, DOI: 10.1007/s12272-013-0197-0

A.10 Mehmet Alp, Ali Hakan Göker, Nurten Altanlar, “Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles” Turkish Journal of Chemistry (ISI), 38; 152-156 pp., 2014, DOI: 10.3906/kim-1303-81 

A.11 Christopher A. Rice, Beatrice L. Colon, Mehmet Alp, Hakan Göker, David W. Boykin, Dennis E. Kyle, “Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens” Antimicrobial Agents and Chemotherapy, 59, 4, 2037-2044, 2015, DOI: 10.1128/AAC.05122-14

A.12  A. Selen Gurkan-Alp, Hakan Göker, Mehmet Alp, Tulin Ozkan, Asuman Sunguroglu, “Synthesis and anticancer effects of some nomel 2-(4-phenoxyphenyl)-1H-benzimidazole derivatives on K562 cell line” Archives of Pharmacal Research (ISI), 38, 650-658, 2015, DOI: 10.1007/s12272-014-0438-x

A.13 Mehmet Alp, A. Selen Gurkan-Alp, Tulin Ozkan, Asuman Sunguroglu, “Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl- 1H-benzimidazole derivatives”, Zeitschrift für Naturforschung C, 70 (3-4)c, 79-85, 2015, DOI: 10.1515/znc-2014-4189

A.14 Fatima Doganc, Mehmet Alp, Hakan Goker “Separation and identification of the mixture of 2-(3,4-dimethoxyphenyl)-1-n-propyl or (4-chlorobenzyl)-5 and (6)- 1H-benzimidazolecarbonitriles” Magn. Reson. Chem., 54, 851–857, 2016, DOI: 10.1002/mrc.4463

B. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler :

B1. Hakan Göker, Mehmet Alp, Sulhiye Yıldız, "Synthesis & Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazol-5-Carboxamidines" World Conference on Magic Bullets Celebrating Paul Ehrlich’s 150 th Birthday, Program and Abstracts, A5 pp., Nürnberg, Almanya, Eylül 2004.

B2. Hakan Göker, Mehmet Alp, Sulhiye Yıldız, "Synthesis and Potent Antistaphylococcus Activity of Some Novel 1H-Benzimidazole-5-Carboxamidines" 4th Central European Conference: Chemistry towards Biology, Book of Abstracts, 85 pp., Dobogoko, Macaristan, Eylül 2008.

B3. Mehmet Alp, Hakan Göker, Reto Brun, Sulhiye Yıldız, "Synthesis and Antiparasıtıc and Antifungal Evaluation of 2'-Arylsubstituted-1H,1'H-[2,5']Bisbenzimidazolyl-5-Carboxamidines" International Conference on Medicinal Chemistry (RICT-45), Drug Discovery and Selection, 104 (SL04) pp., Orleans, Fransa, Temmuz, 2009.

B4. Hakan Göker, Mehmet Alp, Zeynep Ateş-Alagöz, Sulhiye Yıldız, Synthesis and Potent Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles" 16th European Symposium on Organic Chemistry (ESOC 2009) ESOC 2009, 16th European Symposium on Organic Chemistry, Book of Abstracts, 243 (P1.176) pp., Prag, Çek Cumhuriyeti, Temmuz, 2009.

B5. Hacer Karataş, Mehmet Alp, Hakan Göker, "Synthesis of Some Novel 1H-Benzimidazole Derivatives Carrying Amide and Amidine Groups" 18th International Conference on Organic Synthesis, 342 pp., Bergen, Norveç, Ağustos, 2010.

B6. Mehmet Alp, Hakan Göker, "Synthesis of Some Novel N-Substituted Amidino-1-hydroxybenzimidazole Derivatives (Some Novel N-Substituted Amidino-1-Hydroxybenzimidazole Derivatives as Potential Antimicrobial Agents)" 4th European Conference on Chemistry for Life Sciences (4ECCLS), Programme & Book of Abstracts, 193 pp., Budapeşte, Macaristan, 31 Ağustos-3 Eylül 2011.

 B7. Mehmet Alp, Hakan Göker, "Synthesis of Some Novel 2-(4-(1H-Benzimidazol-1-yl)phenyl)-1H-Benzimidazole Derivatives" BOSS XIII,13th Belgian Organic Synthesis Symposium, Programme & Book of Abstracts, 163 (P116) pp., Leuven, Belçika, Temmuz, 2012. 

B8. Hakan Göker, Hacer Karatas, Mehmet Alp, Sulhiye Yıldız, "Synthesis and Potent in vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents" BOSS XIII,13th Belgian Organic Synthesis Symposium, Programme & Abstracts, 156 (P108) pp., Leuven, Belçika, Temmuz, 2012.

B9. Mehmet Alp, Hakan Göker, "Synthesis of Some Novel 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives"  (RICT-49), Drug Discovery and Selection, 211 (HT035) pp., Nice, Fransa, 3-5 Temmuz, 2013.

B10. Tulin  Ozkan, Asuman Sunguroglu, Mehmet Alp,"Antiproliferative activities of some 2-[4-(1H-benzimidazol-1-yl) phenyl]-1H-benzimidazole derivatives" International Symposium on Pharmaceutical Sciences (ISOPS-11), Book of Abstract, 269 (P205) Ankara, Türkiye, 09-12 Haziran 2015.

B11. Mehmet Alp, A. Selen Gurkan-Alp, Tulin Ozkan, Asuman Sunguroglu, “Anticancer evaluation of Some 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives” International Symposium on Pharmaceutical Sciences (ISOPS-11), Book of Abstract, 289 (P228), Ankara, Türkiye, 09-12 Haziran 2015.

B12.Fatima Doganc, Mehmet Alp, Hakan Goker “Separation and identification of the mixture of 2-(3,4-dimethoxyphenyl)-1-n-propyl or (4-chlorobenzyl)-5 and (6)- 1H-benzimidazolecarbonitriles”  The 27th European Colloquium on Heterocyclic Chemistry, Book of Abstract, 139 (P020), Amsterdam, Hollanda, 3-6 Haziran 2016.

B13. Mehmet Alp, A.Selen Gurkan-ALP, Arzu Z. Karabay, Erdem Buyukbingol, Synthesis and anticancer effects of some novel benzimidazole-derived PARP inhibitor molecules, 2nd International Gazi Pharma Symposium Series (GPSS-2017), 272 pp, (P203), Ankara, Türkiye, 11-13 Ekim 2017.

B14.  Mehmet Alp,"Synthesis Of Some Novel N-Substituted 4-(1H-Benzimidazol-1-yl)-Benzamide DerivativesInternational Symposium on Pharmaceutical Sciences (ISOPS-12), Book of Abstract, 387-388 (P461) Ankara, Türkiye, 26-29 Haziran 2018.

C. Ulusal hakemli dergilerde yayımlanan makaleler :

C1. Canan Kus, Mehmet Alp, "Sistemik Mantar Enfeksiyonlarının Tedavisinde Yeni Hedefler Ve Yeni Bileşikler (New Targets And New Compounds For The Treatment Of Systemic Fungal Infections)", Ankara Üniversitesi Eczacılık Fakültesi Dergisi (Journal of Faculty of Pharmacy of Ankara University) , 91-131 pp., 2002.

D. Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler:

D1. Mehmet Alp, Hakan Göker, 2.Ulusal Farmasötik Kimya Kongresi konferansı dahilinde "2.Ulusal Farmasötik Kimya Kongresi, 13-15 Kasım 2009, Mersin" bildiri kitapçığındaki "N-Sübstitüe Amidin Grubu Taşıyan Benzimidazol Türevi Bileşiklerin Sentez, Yapı Aydınlatmaları Ve Antimikrobiyal Etkileri Üzerinde Çalışmalar.", 5 (S-4) pp., Mersin, Türkiye, Kasım 2009.

D2. Mehmet Alp, 1.Ulusal Anadolu Üniversitesi Eczacılık Fakültesi Sempozyumu dahilinde “Anes 2017 Özet Kitapçığı” bildiri kitapçığındaki “Apoptoziste Görev Alan İlaç Hedefleri ve Bu Hedefleri Etkileyen Bileşikler.”  , S5, 23pp, Eskişehir, Türkiye, 01-02 Haziran 2017 (Sözlü Sunum).