ASSOC.PROF.DR. MEHMET ALP    
Name : MEHMET
Surname : ALP
E-Mail :
Phone Number : 0 (312) 2033080
Title : ASSOC.PROF.DR.
Unit : FACULTY OF PHARMACY
Department : Pharmaceutical Chemistry
Personal Information

Academic Degrees 

1998   B.Sc, Ankara University, Faculty of Pharmacy, Ankara.

2001   M.Sc, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical  

          Chemistry, Ankara.

2007  Ph.D, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical  

          Chemistry, Ankara.

2013   Assoc. Prof. Dr, Ankara University, Faculty of Pharmacy, Department of 

          Pharmaceutical  Chemistry, Ankara.

Employment History

1999-2005 Research Assistant University, Faculty of Pharmacy, Department of  

                Pharmaceutical Chemistry, Ankara.

2005-2015 SpecialistUniversity, Faculty of Pharmacy, Department of 

                Pharmaceutical Chemistry, Ankara.

 2015-          Assoc. Prof. Dr, Ankara University, Faculty of Pharmacy, Department of

                 Pharmaceutical  Chemistry, Ankara.

Awards

1. 2005-2007 Novartis Pharmaceutical and Medicinal Chemistry, First winner Prize.

2. 2009-2010Novartis Pharmaceutical and Medicinal Chemistry, Second winner prize.

Publications

A. Articles in Refereed Journals

A1. Hakan Göker, Mehmet Alp, Sulhiye Yıldız, "Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines", Molecules (ISI), 10; 1377-1386 pp., 2005, DOI: 10.3390/10111377

A2. Zeynep Ates-Alagöz, Mehmet Alp, Canan Kus, Sulhiye Yıldız, Erdem Buyukbingol,Hakan Göker, "Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles", Archiv der Pharmazie, Chemistry in Life Science (ISI), 339; 74-80 pp., 2006, DOI: 10.1002/ardp.200500168

A3. F.Betül Kaynak, Süheyla Özbey, Meral Tuncbilek, Mehmet Alp, "Synthesis and crystal structure of 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole", Structural Chemistry (ISI), 19; 477-480 pp., 2008, DOI: 10.1007/s11224-008-9306-y

A4. Mehmet Alp, Hakan Göker, Reto Brun, Sulhiye Yıldız., "Synthesis and antiparasitic and antifungal evaluation of 20’-arylsubstituted-1H,1’H-[2,5’]bisbenzimidazolyl-5-carboxamidines", European Journal of Medicinal Chemistry(ISI), 44; 2002-2008 pp., 2009, DOI: 10.1016/j.ejmech.2008.10.003

A5. Hakan Göker, Mehmet Alp, Zeynep Ateş-Alagöz, Sulhiye Yıldız, "Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles", Journal of Heterocyclic Chemistry (ISI), 46; 936-948 pp., 2009, DOI: 10.1002/jhet.179

A6. Hakan Göker, Maksut Coşkun, Mehmet Alp, "Isolation and identification of a new acetildenafil analogue used to adulterate a dietary supplement: dimethylacetildenafil", Turkish Journal of Chemistry (ISI), 34; 157-163 pp., 2010 , DOI: 10.3906/kim-1002-25

A7. Hacer Karataş, Mehmet Alp, Sulhiye Yıldız, Hakan Göker., "Synthesis and Potent In vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents", Chemical Biology & Drug Design (ISI), 80; 237-244 pp., 2012 , DOI: 10.1111/j.1747-0285.2012.01393.x

A.8 Mehmet Alp, Maksut Coşkun, Hakan Göker, "Isolation and identification of a new sildenafil analogue adulterated in energy drink: propoxyphenyl sildenafil", Journal of Pharmaceutical and Biomedical Analysis (ISI), 72; 155-158 pp., 2013, DOI: 10.1016/j.jpba.2012.09.017

A.9 Mehmet AlpHakan Göker, Tulin Ozkan, Asuman Sunguroglu, “Synthesis and cytotoxic evaluation of novel N-substituted amidino-1-hydroxybenzimidazole derivatives” Archives of Pharmacal Research (ISI)37, 580-587pp., 2014, DOI: 10.1007/s12272-013-0197-0

A.10 Mehmet Alp, Ali Hakan Göker, Nurten Altanlar, “Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles” Turkish Journal of Chemistry (ISI), 38; 152-156 pp., 2014DOI: 10.3906/kim-1303-81 

A.11 Christopher A. Rice, Beatrice L. Colon, Mehmet Alp, Hakan Göker, David W. Boykin, Dennis E. Kyle, “Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens” Antimicrobial Agents and Chemotherapy, 59, 4, 2037-2044, 2015, DOI: 10.1128/AAC.05122-14

A.12  A. Selen Gurkan-Alp, Hakan Göker, Mehmet Alp, Tulin Ozkan, Asuman Sunguroglu, “Synthesis and anticancer effects of some nomel 2-(4-phenoxyphenyl)-1H-benzimidazole derivatives on K562 cell line” Archives of Pharmacal Research (ISI), 38,650-658, 2015, DOI: 10.1007/s12272-014-0438-x

A.13 Mehmet Alp, A. Selen Gurkan-Alp, Tulin Ozkan, Asuman Sunguroglu, “Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl- 1H-benzimidazole derivatives”, Zeitschrift für Naturforschung C, 70 (3-4)c, 79-85, 2015, DOI: 10.1515/znc-2014-4189

A.14 Fatima Doganc, Mehmet Alp, Hakan Goker “Separation and identification of the mixture of 2-(3,4-dimethoxyphenyl)-1-n-propyl or (4-chlorobenzyl)-5 and (6)- 1H-benzimidazolecarbonitriles” Magn. Reson. Chem., 54, 851–857, 2016, DOI: 10.1002/mrc.4463

B. Published conference Abstracts

B1. Hakan Göker, Mehmet Alp, Sulhiye Yıldız, "Synthesis & Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazol-5-Carboxamidines" World Conference on Magic Bullets Celebrating Paul Ehrlich’s 150 th Birthday, Program and Abstracts, A5 pp., Nürnberg, Germany,2004.

B2. Hakan Göker, Mehmet Alp, Sulhiye Yıldız, "Synthesis and Potent Antistaphylococcus Activity of Some Novel 1H-Benzimidazole-5-Carboxamidines" 4th Central European Conference: Chemistry towards Biology, Book of Abstracts, 85 pp., Dobogoko, Hungary, 2008.

B3. Mehmet Alp, Hakan Göker, Reto Brun, Sulhiye Yıldız, "Synthesis and Antiparasıtıc and Antifungal Evaluation of 2'-Arylsubstituted-1H,1'H-[2,5']Bisbenzimidazolyl-5-Carboxamidines" International Conference on Medicinal Chemistry (RICT-45), Drug Discovery and Selection, 104 (SL04) pp., Orleans, France, 2009.

B4. Hakan Göker, Mehmet Alp, Zeynep Ateş-Alagöz, Sulhiye Yıldız, Synthesis and Potent Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles" 16th European Symposium on Organic Chemistry (ESOC 2009) ESOC 2009, 16th European Symposium on Organic Chemistry, Book of Abstracts, 243 (P1.176) pp., Prague, Czech Republic, 2009.

B5. Hacer Karataş, Mehmet Alp, Hakan Göker, "Synthesis of Some Novel 1H-Benzimidazole Derivatives Carrying Amide and Amidine Groups" 18th International Conference on Organic Synthesis, 342 pp., Bergen, Norway, 2010.

B6. Mehmet Alp, Hakan Göker, "Synthesis of Some Novel N-Substituted Amidino-1-hydroxybenzimidazole Derivatives (Some Novel N-Substituted Amidino-1-Hydroxybenzimidazole Derivatives as Potential Antimicrobial Agents)" 4th European Conference on Chemistry for Life Sciences (4ECCLS), Programme & Book of Abstracts, 193 pp., Budapest, Hungary, 2011.

 B7. Mehmet Alp, Hakan Göker, "Synthesis of Some Novel 2-(4-(1H-Benzimidazol-1-yl)phenyl)-1H-Benzimidazole Derivatives" BOSS XIII,13th Belgian Organic Synthesis Symposium, Programme & Book of Abstracts, 163 (P116) pp., Leuven, Belgium, 2012. 

B8. Hakan Göker, Hacer Karatas, Mehmet Alp, Sulhiye Yıldız, "Synthesis and Potent in vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents" BOSS XIII,13th Belgian Organic Synthesis Symposium, Programme & Abstracts, 156 (P108) pp., Leuven, Belgium, 2012.

B9. Mehmet Alp, Hakan Göker, "Synthesis of Some Novel 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives"  (RICT-49), Drug Discovery and Selection, 211 (HT035) pp., Nice, France, July 3-5, 2013.

B10. Tulin  Ozkan, Asuman Sunguroglu, Mehmet Alp,"Antiproliferative activities of some 2-[4-(1H-benzimidazol-1-yl) phenyl]-1H-benzimidazole derivatives" International Symposium on Pharmaceutical Sciences (ISOPS-11), Book of Abstract, 269 (P205) Ankara, Turkey, June 09-12, 2015.

B11. Mehmet AlpA. Selen Gurkan-Alp, Tulin Ozkan, Asuman Sunguroglu, “Anticancer evaluation of Some 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives” International Symposium on Pharmaceutical Sciences (ISOPS-11), Book of Abstract, 289 (P228), Ankara, Turkey, June 09-12, 2015.

B12.Fatima Doganc, Mehmet AlpHakan Goker “Separation and identification of the mixture of 2-(3,4-dimethoxyphenyl)-1-n-propyl or (4-chlorobenzyl)-5 and (6)- 1H-benzimidazolecarbonitriles”  The 27th European Colloquium on Heterocyclic Chemistry, Book of Abstract, 139 (P020), Amsterdam, The Netherlands, July 3-6, 2016.

B13. Mehmet AlpA.Selen Gurkan-ALP, Arzu Z. Karabay, Erdem Buyukbingol, Synthesis and anticancer effects of some novel benzimidazole-derived PARP inhibitor molecules, 2nd International Gazi Pharma Symposium Series (GPSS-2017), 272 pp, (P203), Ankara, Turkey, October, 11-13, 2017.

B14.  Mehmet Alp,"Synthesis Of Some Novel N-Substituted 4-(1H-Benzimidazol-1-yl)-Benzamide DerivativesInternational Symposium on Pharmaceutical Sciences (ISOPS-12), Book of Abstract, 387-388 (P461) Ankara, Turkey, June 26-29, 2018.

C. Articles in Refereed National Journals

C1. Canan Kus, Mehmet Alp, "Sistemik Mantar Enfeksiyonlarının Tedavisinde Yeni Hedefler Ve Yeni Bileşikler (New Targets And New Compounds For The Treatment Of Systemic Fungal Infections)", Ankara Üniversitesi Eczacılık Fakültesi Dergisi (Journal of Faculty of Pharmacy of Ankara University) , 91-131 pp., 2002. 

D. Published national conference Abstracts

D1. Mehmet Alp, Hakan Göker, 2.Ulusal Farmasötik Kimya Kongresi konferansı dahilinde "2.Ulusal Farmasötik Kimya Kongresi, 13-15 Kasım 2009, Mersin" bildiri kitapçığındaki "N-Sübstitüe Amidin Grubu Taşıyan Benzimidazol Türevi Bileşiklerin Sentez, Yapı Aydınlatmaları Ve Antimikrobiyal Etkileri Üzerinde Çalışmalar.", 5 (S-4) pp., Mersin, Türkiye, Kasım 2009.