PROF.DR. MEHMET UĞUR    
Name : MEHMET
Surname : UĞUR
E-Mail : mugur@medicine.ankara.edu.tr
Phone Number : +90 312 595 8187
Title : PROF.DR.
Unit : FACULTY OF MEDICINE
Department :
Personal Information

Name: Mehmet Uğur MD, PhD.

 

Title : Professor.

 

Affiliation: Department of Biophysics, Ankara University School of Medicine. Ankara, Turkey.

 

Address:

Department of Biophysics,

Ankara University School of Medicine

A. Adnan Saygun cad.

Altındağ - Ankara

TURKEY

06230

 

e-mail: mugur@medicine.ankara.edu.tr

 

Phone:

+90 312 595 8172

+90 535 893 1397 (mobile)

 

Birth Date: 18-01-1965

 

Nationality: Turkish.

 

Education:

1982-1988    University of Ankara, School of Medicine                              Medical Doctor.

1989-1992    University of Ankara, School of Medicine, Dpt. Pharmacology          PhD. (Pharmacology)

1998-2000    University of Ankara, School of Medicine, Dpt. Biophysics   PhD. (Biophysics)


Professional Experience:

Between 1992 -1997 I worked in Massachusetts University Medical School Physiology Dpt. (Massachusetts, USA) with Drs Joshua J. Singer and John V. Walsh Jr. as a post doctoral researcher.  My research was basically focused on characterization of a P2X7 like receptor that we discovered in gastrick smooth muscle cells of toad by using patch-clamp and intra cellular Ca2+ measurement techniques.

In 1998 I worked for three months in “Unite de Recherches de Physiopathologie Cardiovasculaire INSERM, U-390” (Montpellier, France) In the laboratory of Dr. Guy Vassort, as an exchange researcher, supported by the French government. We discovered and characterized a novel purinergic response in cardiac myocytes.

I have been working in Ankara University School of Medicine Dpt. Biophysics since 1997. My research is mostly focused on P2X7 receptor signaling mechanisms by using live-cell confocal microscopy, electrophysiology and molecular biology techniques.

Areas of Expertise:

Electrophysiology, patch-clamp, live cell imaging, confocal microscopy, fluorescent intracellular ion measurement, receptor signaling, P2X receptors, P2X7 receptor, GPCR signaling.

 

Selected Publications:

 1. Ugur M., Drummond R. M., Zou H., Sheng P., Singer J. J., Walsh Jr. J. V. An ATP-Gated Cation Channel Wıth Some P2Z like characteristics in Gastric Smooth Muscle of Toads. Journal of Physiology (London). 498 (2): 427-442, 1997.

2. Petrou S., Ugur M., Drummond R. M., Singer J. J., Walsh Jr. J. V. P2X7 Purinoceptor expression in Xenopus oocytes is not sufficent to produce a pore-forming P2Z-like phenotype.  FEBS Letters. 411(2-3): 339-345, 1997.

3. Mitra S., Ugur M., Ugur O., H.. Goodman M,. McCullough J. R, Yamaguchi H.. S-albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle. Molecular Pharmacology 52 (3): 347-354, 1998.

4. Zou H., Ugur M., Drummond R., Singer J. J. Coupling of a P2Z-like purinoceptor to a fatty acid activated K+ channel in toad gastric smooth muscle cells. Journal of Physiology (London) 534: 59-70, 2001.

5. Yaras N., Ugur M., Ozdemir S., Gurdal H., Purali N., Lacampagne A., Vassort G., Turan B. Effects of Diabetes on Ryanodine Receptor Ca Release Channel and Ca Homeostasis in Rat Heart. Diabetes. 54: 3082-3088, 2005.

6. Alvarez J., Coulombe A., Cazorla O.F., Ugur M., Rauzier J.M., Magyar J., Mathieu E.L., Boulay G., Souto R., Bideaux P., Salazar G., Rassendren F., Lacampagne A., Fauconnier J., Vassort G. ATP/UTP activate cation-permeable channels with TRPC3/7 properties in rat cardiomyocytes. American Journal of Physiol Heart Circulation Physiology. 295: H21-28, 2008.

7. Serife Cankurtaran-Sayar, Kemal Sayar, and Mehmet Ugur. P2X7 Receptor Activates Multiple Selective Dye-Permeation Pathways in RAW 264.7 and Human Embryonic Kidney 293 Cells Molecular Pharmacology. 76:1–10, 2009.

8. Ugur M, Ugur O. A Mechanism Based Approach to P2X7 Receptor Action. Molecular Pharmacology. 95(4):442-450, 2019.