ASSOC.PROF.DR. MELTEM ÜNLÜSOY    
Name : MELTEM
Surname : ÜNLÜSOY
E-Mail : munlusoy@pharmacy.ankara.edu.tr, munlusoy@gmail.com
Phone Number : 0 312 2033079
Title : ASSOC.PROF.DR.
Unit : FACULTY OF PHARMACY
Department : PHARMACEUTICAL CHEMISTRY
Personal Information

  

Meltem CEYLAN-UNLUSOY

Résumé

Ankara University
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
Tandogan-Ankara, 06100 Turkey
(+90) (312) 2033079
Email:  munlusoy@pharmacy.ankara.edu.tr

 

 


EDUCATION

PhD degree: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, 2009 (Thesis title: Studies on Some New Chromonyl-Thiazolidinediones With Antidiabetic Activity)

Master’s degree: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, 2001 (Thesis title: Investigation on Some New Antibacterial Flavonoid Derivatives) 

Undergraduate degree:  Faculty of Pharmacy, University of Ankara, 1997

CURRENT POSITION

Associate Professor at Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara

AREAS OF INTEREST:

Flavonoids, chromones, penicillin derivatives, thiazolidinediones, antidiabetic activity, antibacterial activity, anticancer activity, design and synthesis of drug molecules, analysis of drug molecules (IR, NMR, Mass)

Postdoctoral Studies

Guest researcher at Uppsala University, Faculty of Pharmacy, Department of Medicinal Chemistry, 2012

PUBLICATIONS

· M. Tunçbilek, O. Bozdağ-Dündar, G. Ayhan-Kılcıgil, M. Ceylan, A. Waheed, E.J. Verspohl, R. Ertan, “Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives-fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones”, Il Farmaco (ISI), 58, 79-83, 2003.

· O. Bozdağ-Dündar, M. Ceylan, N. Altanlar, R. Ertan, “Synthesis and antimicrobial activities of some new flavone derivatives”, Acta Pharmaceutica Turcica, 45, 31-35, 2003.

· O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, N. Altanlar, R. Ertan, “Synthesis and biological activity of some new flavone derivatives”, Arzneimittel-Forschung (Drug Research) (ISI), 55(2), 102-106, 2005, DOI: 10.1055/s-0031-1296830

· M. Ceylan-Ünlüsoy, N. Altanlar, R. Ertan, “Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin”, Turkish Journal of Chemistry (ISI), 29(2), 187-191, 2005.

· Ö. Özgen, M. Ceylan-Ünlüsoy, O. Bozdağ-Dündar, R. Ertan, E. Kendi,  “3-(4-Chlorobenzyl)-5-(4-oxo-4H-chromen-3-ylmethylene)-1,3-thiazolidine-2,4-dione”, Acta Crystallographica Section E, E61: o870-o872, 2005, DOI:10.1107/S1600536805006252

· M. Ceylan-Ünlüsoy, O. Bozdağ-Dündar, N. Altanlar, R. Ertan, “Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl-thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives”, Turkish Journal of Chemistry (ISI), 30(3), 355-360, 2006.

· O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, E.J. Verspohl, R. Ertan, “Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring”,  Arzneimittel-Forschung (Drug Research) (ISI), 56(9), 621-625 (2006). DOI: 10.1055/s-0031-1296762

· M. Aslantaş, M. Ceylan-Ünlüsoy, R. Ertan, E. Kendi, O. Büyükgüngör, “3-Methyl-5-(4-oxo-4H-chromen-3-ylmethylene)-1,3-thiazolidine-2,4-dione”, Acta Crystallographica Section E, E62: o1471-o1473, 2006, DOI:10.1107/S1600536806008762

· M. Aslantaş, M. Ceylan-Ünlüsoy, R. Ertan, E. Kendi, O. Büyükgüngör, “3-Ethyl-5-(4-oxochroman-3-ylmethylene)-1,3-imidazolidine-2,4-dione”, Acta Crystallographica Section E, E63: o184-o185, 2007, DOI:10.1107/S1600536806052378

· O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, E.J. Verspohl, R. Ertan, “Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones”, Arzneimittel-Forschung (Drug Research) (ISI), 57(8), 532-536, 2007, DOI: 10.1055/s-0031-1296644

· M. Aslantaş, E. Kendi, M. Ceylan-Ünlüsoy, R. Ertan, O. Büyükgüngör, “Synthesis and crystal structure of 3-ethyl-2-(ethylthio)-5-(4-oxo-4H-chromen-3-yl methylene)imidazolidine-4-one”, Analytical Sciences (ISI), 23(7), x113-x114, 2007, DOI: 10.2116/analscix.23.x113.

· O. Bozdağ-Dündar, N. Daş-Evcimen, M. Ceylan-Ünlüsoy, R. Ertan, M. Sarıkaya, “Some new thiazolyl thiazolidinedione derivatives as aldose reductase inhibitors”, Medicinal Chemistry Research (ISI), 16, 39-47, 2007, DOI: 10.1007/s00044-007-9008-9

· M. Ceylan-Ünlüsoy, O. Bozdağ-Dündar, N. Altanlar, R. Ertan, “Studies on the synthesis of some new substituted benzylamino and phenyl-acrylamido-methyl flavone derivatives”, Medicinal Chemistry Research (ISI), 16, 170-178, 2007, DOI: 10.1007/s00044-007-9021-z

· O. Bozdağ-Dündar, T. Çoban, M. Ceylan-Ünlüsoy, R. Ertan, “Radical scavenging capacities of some thiazolylthiazolidine-2,4-dione derivatives”, Medicinal Chemistry Research (ISI) 18(1), 1-7, 2009, DOI: 10.1007/s00044-007-9081-0

· I. Kruk, O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, R. Ertan, H.Y. Aboul-Enein, T. Michalska, “Scavenging capacities of some thiazolyl thiazolidine-2,4-dione compounds on superoxide radical, hydroxyl radical, and DPPH radical”, Luminescence (ISI), 24(4),  230-235, 2009, DOI: 10.1002/bio.1105

· A. Menteşe, M. Ceylan-Ünlüsoy, O. Bozdağ-Dündar, N. Altanlar, R. Ertan, “Synthesis and antimicrobial activity of some novel thiazolidine-2,4-dione derivatives”,  Arzneimittelforschung (ISI), 59(12), 659-665, 2009, DOI: 10.1055/s-0031-1296456

· M. Ceylan-Ünlüsoy, N. Daş-Evcimen, M. Sarıkaya,  O. Bozdağ-Dündar,  R. Ertan, “The inhibitory effects of thiazolyl-2,4-thiazolidinedione compounds on the rat kidney aldose reductase enzyme-Tiyazolil-2,4-tiyazolidindion bileşiklerinin rat karaciğer aldoz redüktaz enzimi üzerindeki inhibitör etkileri”, Ankara Üniversitesi Eczacılık Fakültesi Dergisi (Journal of Faculty of Pharmacy of Ankara University), 38 (3), 181-190, 2009.

· M. Ceylan-Ünlüsoy, E.J. Verspohl, R. Ertan, “Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones”, Journal of Enzyme Inhibition and Medicinal Chemistry (ISI), 25(6), 784-789, 2010, DOI: 10.3109/14756360903357544

· M. Ceylan Ünlüsoy, C. Kazak, O. Bayro, E.J. Verspohl, R. Ertan, O. Bozdağ Dündar, “Synthesis and antidiabetic activity of 2,4-thiazolidindione, imidazolidinedione and 2-thioxo-imidazolidine-4-one derivatives bearing 6-methyl chromonyl pharmacophore”, Journal of Enzyme Inhibition and Medicinal Chemistry (ISI), 28(6), 1205-1210, 2013, DOI: 10.3109/14756366.2012.723207

· P. Berczynski, I. Kruk, T. Piechowska, M. Ceylan-Ünlüsoy, O. Bozdağ-Dündar, H.Y. Aboul-Enein, “Free radical scavenging activity of novel thiazolidine-2,4-dione derivatives”, Luminescence (ISI), 28, 900-904, 2013, DOI: 10.1002/bio.2454

· J. Wannberg, C. Wallinder, M. Ünlüsoy, C. Sköld, M. Larhed, “One-Pot, two-step, microwave-assisted palladium-catalyzed conversion of aryl alcohols to aryl fluorides via aryl nonaflates”, Journal of Organic Chemistry (ISI), 78, 41844189, 2013, DOI: 10.1021/jo400255m

· P. Berczynski, A. Kładna, I. Kruk, T. Piechowska, H.Y. Aboul-Enein, O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, “Antioxidant activities of some new chromonyl-2,4-thiazolidinediones and chromonyl-2,4-imidazolidinediones having chromone cores”, Journal of Fluorescence (ISI), 23, 1319–1327, 2013, DOI: 10.1007/s10895-013-1266-y

· P. Berczynski, E. Duchnik, I. Kruk, T. Piechowska, H.Y. Aboul-Enein, O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, “6-Methyl 3-chromonyl 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxoimidazolidine-4-one compounds: novel scavengers of reactive oxygen species”,  Luminescence (ISI), 29(4), 367-373, 2014, DOI: 10.1002/bio.2554

· A. Kładna, P. Berczynski, T. Piechowska, I. Kruk, H.Y. Aboul-Enein, M. Ceylan-Ünlüsoy, E.J. Verspohl, R. Ertan, “Studies on the antioxidant activities of some new chromone compounds”, Luminescence (ISI), 29(7), 846-853, 2014, DOI 10.1002/bio.2631

· P. Berczynski, A. Kładna, T. Piechowska, I. Kruk, ; O. Bozdağ-Dündar, H.Y. Aboul-Enein, M. Ceylan-Ünlüsoy, R. Ertan, “Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core” Luminescence (ISI), 29(8), 1107-1112, 2014, DOI: 10.1002/bio.2667

· Ö. Yıldırım, N. Amirzadeh-Khiabani, M. Ceylan-Ünlüsoy, N. Daş-Evcimen, M. Sarikaya, R. Ertan, “Alterations of aldose reductase and superoxide dismutase activities by some chromonyl-2, 4-thiazolidinedione derivatives  [Bazı kromonil-2,4-tiyazolidindiyon türevleri ile aldoz redüktaz ve süperoksit dismutaz aktivitelerindeki deǧişiklikler]” Ankara Üniversitesi Veteriner Fakültesi Dergisi, 61(4), 249-254, 2014  DOI: 10.1501/Vetfak_0000002638

· I. Kruk, T. Piechowska, P. Berczynski, A. Kładna, O. Bozdağ-Dündar, M. Ceylan-Ünlüsoy, H.Y. Aboul-Enein, “Studies on the antioxidant activity of some chromonylrhodanine derivatives”  Luminescence (ISI), 30: 556–563, 2015, DOI: 10.1002/bio.2785

· C. Ozen, M. Ceylan-Unlusoy, N. Aliary, M. Ozturk, O. Bozdag-Dundar, “Thiazolidinedione or Rhodanine: A Study on Synthesis and Anticancer Activity Comparison of Novel Thiazole Derivatives” J Pharm Pharm Sci (www.cspsCanada.org) (ISI) 20, 415-427, 2017, DOI: http://dx.doi.org/10.18433/J38P9R

· G.A. İşbilen, M. Ceylannlüsoy, M. Sarikaya, Oya Bozdağ-Dündar, Net D-Evcimen “In Vitro Aldose Reductase Inhibitory Activity of Some 2,4-Thiazolidinedione Derivatives” Am. J. PharmTech Res. 7(2): 432-440, 2017.

· C. Ozen, M. Ceylan-Unlusoy, M. Ozturk, O. Bozdag-Dundar, “A novel chromonyl thiohydantoin with anti-​proliferative action on primary hepatocellular carcinoma cells.” Medicinal Chemistry Research (ISI), 27: 153-160, 2018, DOI: 10.1007/s00044-017-2037-0