ASSOC.PROF.DR. ÖZGE ÜLKER    
Name : ÖZGE
Surname : ÜLKER
E-Mail : oulker@pharmacy.ankara.edu.tr
Phone Number : 203 31 26
Title : ASSOC.PROF.DR.
Unit : FACULTY OF PHARMACY
Department :
Personal Information


 

 

NAME: Ozge Cemiloglu Ulker

 

DATE OF BIRTH: 13.06.1979

 

CURRENT POSITION: Assoc. Prof

 

AFFILIATION: Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara,Turkey

 

EDUCATION

 

Ø  PhD degree: Ankara University Faculty of Pharmacy Department of Toxicology, 2010, “Estimation of Relative Contact Allergenic Potency of the Chemicals by Using Non-Radioactive Local Lymph Node Assay and Comparison with the Patch Test Results”  Supervisor: Prof. Dr. Asuman Karakaya

     

Ø  Master’s degree: Ankara University, Faculty of Pharmacy, Department of Toxicology, 2004, “The Role of  Pro-inflammatory Cytokines and Antioxidant Enzymes in Coal Workers’ Pneumoconiosis and Disease Clinical Severity”, Supervisor: Assoc. Prof. Berran Yucesoy- Prof. Dr. Asuman Karakaya

 

Ø  Undergraduate degree:Ankara University, Faculty of Pharmacy, 2001

 

 

AREAS OF INTEREST: Immunotoxicology, occupational toxicology, genetic toxicology, in vitro and alternative toxicity tests

 

PROJECTS

 

Ø  The role of cytokines and cytokine gene polymorphism in development and progression of coal workers’ pneumoconiosis. Supported by Ankara University Research Fund, Project number: 2003–08-03-036,

Position: Researcher

 

 

Ø  Investigation on incidence and levels of ochratoxin A (OTA) in human urine samples collected from different region of Turkey by immunoaffinity column clean-up and high performance liquid chromatography. Supported by The Scientific and Technological Research Council of Turkey, Project Number: 105S412

Position: Researcher

 

Ø  Estimation of Relative Contact Allergenic potency of the Chemicals by using Non-Radioactive Local Lymph Node Assay and Comparison with the Patch Test Results Supported by  The Scientific and Technological Research Council of Turkey , Project Number: 107S365 (Doctorate Project)

Position: Researcher

 

Ø  Investigation of antioxidant effect of boric acid in some cell cultures in vitro. Supported by Ankara University Research Fund, Project number: 12B3336007

Position: Project manager

 

Ø  Investigation of the TiO2 solid nanoparticles safety for human health by using in vitro tests. Supported by  The Scientific and Technological Research Council of Turkey , Project Number: 113S229

Position: Researcher

 

     

TEACHING

 

Pharmaceutical Toxicology

Pharmaceutical Toxicology Practice

Cosmetic Toxicity

Medicines During Pregnancy, Childhood and Elderly

Ecotoxicology

Experimental Toxicology

 

 

PUBLICATIONS

1.    ELKAMA AYLIN, ULKER OZGE, TEKER ERIM, KARAKAYA ASUMAN, KARAKAYA ALİ ESAT (2018). Investigation of hypersensitivity potential of diacetyl by detrmining cytokine profiles,Human and Experimental Toxicology,  37(3), 265-274, DOI:10.1177/0960327117695636

 

2.    YILMAZ SEZEN, USTUNDAG AYLIN, ULKER OZGE, DUYDU YALCIN (2016).Protective effect of boric acid on oxidative DNA damage in chinese hamster lung fibroblast V79 cell lines. Cell Journal, 17 (4), 748-754

3.    ARANCIOGLU SEREN, ULKER OZGE, KARAKAYA ASUMAN (2015). Utilization of ex vivo LLNA:BrdU-ELISA to distinguish the sensitizers from irritants in respect of 3 endpoints-lymphocyte proliferation, ear swelling and cytokine profiles. International Journal of Toxicology, 34(1), 24-30.

4.    CHAREHSAZ MOHAMMAD,SIPAHI HANDE,CELEP MEHMET ENGIN,USTUNDAG AYLIN,ULKER OZGE, DUYDU YALCIN,AYDIN AHMET,YESILADA ERDEM (2015). The fruit extract of Berberis crataegina DC. exerts potent antioxidant activity and protects DNA integrity. DARU Journal of Pharmaceutical Sciences, 23(1), 24-34.

5.    ULKER OZGE, KAYMAK YESIM, KARAKAYA ASUMAN (2014). Allergenicity evaluation of fragrance mix and its ingredients by using ex vivo local lymph node assay–BrdU endpoints. Food and Chemical Toxicology, 65, 162-167.

6.    ATES ILKER, ULKER OZGE, AKDEMIR CIGDEM, KARAKAYA  ASUMAN (2011). Correlation of Ochratoxin A Exposure to Urinary Levels of 8-Hydroxydeoxyguanosine and Malondialdehyde in a Turkish Population. Bulletin of Environmental Contamination and Toxicology, 86(3), 258-262.

7.    ULKER OZGE, KAYMAK YESIM, KARAKAYA ASUMAN (2014). Investigation of allergenicity of some cosmetic mixtures by using ex vivo local lymph node assay-BrdU endpoints. Internatioanal Archives of Allergy and Immunology, 164(4), 301-307.

8.    ULKER OZGE, ATES ILKER, ATAK YUCEL AYSEGUL, KARAKAYA ASUMAN (2013).Evaluation of non-radioactive endpoints of ex vivo local lymph node assay-BrdU to investigate select contact sensitizers. Journal of Immunotoxicology, 10(1), 1-8.

9.    ULKER OZGE, ATES ILKER, ATAK YUCEL AYSEGUL, KARAKAYA ASUMAN (2011). Evaluation of auricular lymph node cell lymphocyte proliferation and cytokine production as nonradioactive endpoints during murine contact allergy. Journal of Immunotoxicology, 8(2), 131-139.

10. AKDEMIR CIGDEM, ULKER OZGE, BASARAN ALAATTIN, OZKAYA SENNUR, KARAKAYA ASUMAN (2010). Estimation of ochratoxin A in some Turkish populationas: an analysis in urine as a simple, sensitive and reliable biomarker. Food and Chemical Toxicology, 48(3), 877-882.

11. ULKER OZGE, YÜCESOY BERRAN, DEMİR ÖZGÜR, TEKİN İSHAK ÖZEL, KARAKAYA ASUMAN (2008). Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers. Human & Experimental Toxicology, 27(12), 871-877.

12. ULKER OZGE, USTUNDAG AYLIN, DUYDU YALCIN, KARAKAYA ASUMAN (2008). Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey. Environmental and Molecular Mutagenesis, 49(3), 232-237.

13. ULKER OZGE, BERRAN YUCESOY, DURUCU MURAT, KARAKAYA ASUMAN (2007). Neopterin as a marker for immune system activation in coal workers' pneumoconiosis. Toxicology and Industrial Health, 23(3), 155-160.

 

 

PARTICIPATING CONGRESS

 

1.    8th International Symposium on Pharmaceutical Sciences (ISOPS-8), June 13-16, 2006, Ankara, Turkey. “Ulker C.O., Yucesoy B., Tekin O.I., Karakaya A., Neopterin as a marker for immune system activation in coal miners pneumoconiosis”

2.    43rd Congress of the European Societies of Toxicology (EUROTOX), 6th Congress of Toxicology in Developing Countries, September 20-24, 2006, Dubrovnik/Cavtat, Croatia. “ Ulker O.C., Ustundag A., Duydu Y., Yucesoy B.,  Karakaya A., Possible genotoxic risk in coal workers’ pneumoconiosis” (Oral Presentation)

3.    6th International Congress of Turkish Society of Toxicology, November 2-5, 2006, Antalya, Turkey. “Ulker O. C., Yucesoy B., Demir O., Karakaya A, Serum and BALF cytokine levels at different stages of pneumoconiosis in coal workers”

4.    6th International Congress of Turkish Society of Toxicology, November 2-5, 2006, Antalya, Turkey. “ Karakaya A., Ulker O.C., Yucesoy B., Durucu M., Neopterin: A novel marker for immune activation in patients with CWP”

5.    5th International Congress on Environmental Mutagens in Human Populations, May 20-24, 2007, Antalya, Turkey. “Ulker O.C., Ustundag A., Duydu Y., Yucesoy B.,  Karakaya A., SCE and MN frequencies in coal workers and coal workers’pneumoconiosis patients”

6.    The 3th  Euro-Asian Conference on Hazardous Waste & Human Health, March 27-30, 2008, Istanbul, Turkey. “Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Karakaya A., Serum and BAL antioxidant enzyme levels as markers of effect in CWP patients”

7.    47th Annual Meeting of the Society of Toxicology, March 16-20, 2008, Seattle, USA. “Karakaya A., Akdemir C., Basaran A., Ulker O.C., Ozkaya S., Estimation of ochratoxin A in Turkish population: An analysis in urine as a simple, sensitive and reliable biomarker”

8.    The 3th  Euro-Asian Conference on Hazardous Waste & Human Health, March 27-30, 2008, Istanbul, Turkey. “Karakaya A.,  Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Serum and BAL cytokine levels as markers at different stages in CWP patients”

9.     The 45th Congress of the European Societies of Toxicology, October 5-8 , 2008, Rhodes, Greece. “Ulker O.C., Yucesoy B., Demir O., Tekin I.O., Karakaya A. ,  Evaluation of antioxidant enzyme levels as biological markers at different stages of pneumoconiosis in coal workers”

10. The 45th Congress of the European Societies of Toxicology, October 5-8 , 2008, Rhodes, Greece, “Karakaya A.,  Ulker O.C., Yucesoy B., Demir O., Tekin I.O.,  Relationship of inflammatory cytokines with disease severity in CWP patients”

11. The 48th Annual Meeting of the Society of Toxicology,  March 15-19, 2009, Baltimore, USA,  “Karakaya A., Ulker O.C., Ates I., The murine local lymph node assay with non-radioactive alternative endpoints”

12. 7th Congress of the Turkish Society of Toxicology with International Participation, 30 May-1 June 2009, Ankara, Turkey. “Ulker O.C., Karakaya A., Ates I., Investigation of allergy and irritancy potency of DNCB and paraphenylenediamine bu using nonradioactive LLNA” (Oral presentation)

13. 7th Congress of the Turkish Society of Toxicology with International Participation, 30 May-1 June 2009, Ankara, Turkey “Akdemir C., Ulker O.C., Basaran A., Ozkaya S., Karakaya A., Estimating ochratoxin A levels in urinary in Turkish population as a sensitive biomarker” 

14. The 9th International Symposium on Pharmaceutical Sciences (ISOPS-9), June 23-26 2009, Ankara, Turkey. “Ulker O.C., Ates I., Karakaya A., The murine local lymph node assay with nonradioactive alternative endpoints”

15. The 46th Congress of the European Societies of Toxicology, September 13-16 2009, Dresden, Germany, “Ulker O.C., Karakaya A., Evaluation of alternative endpoints for non-radioactive local lymph node assay by using two strong sensitizers”

16. 7th Congress of Toxicology in Developing Countries (CTDC), September 6-10 2009,  Sun City, South Africa, “Karakaya A., Akdemir C., Ulker O.C., Başaran A., Ozkaya S., Estimation of ochratoxin A in some Turkish population: An analysis in urine as a simple, sensitive and reliable biomarker”

17. The 47th Congress of the European Societies of Toxicology, XII International Congress of Toxicology, July 19-23 2009, Barcelona, Spain “Karakaya A., Ulker O.C., Evaluation of cytokine production in auricular lymph nodes as an alternative endpoint during murine contact allergy”

18. The 50th Annual Meeting of the Society of Toxicology, March 6-10 2011 Washington DC, USA “Karakaya A,  Ulker O.C.,  Ateş I.,  Atak A.,Evaluation of the non-radioactive endpoints of  LLNA by applying moderate and weak sensitizers,”

 19. The 48th Congress of European Societies of Toxicology, June 17-20 2012 Stockholm, Sweden “Ulker O.C., Ates I., Atak A., Karakaya A., Investigation of sensitizing potency of some cosmetic mixtures”

 20. The 10th International Symposium on Pharmaceutical Sciences (ISOPS-10), June 26-29, 2012, Ankara, Turkey. “Ulker O.C., Ates I., Atak A., Karakaya A., “Investigation of the utility of the non-radioactive endpoints of ex vivo LLNA-BrdU method by using some cosmetic mixtures”

21. The 8th Congresses on Toxicology in Developing Countries (8th CTDC), September 10-13, 2012 Bankgog, Tailand, Karakaya A., Ulker O.C, Ates I, Atak A ., “Evaluation of contact sensitizing potential of fragrance mix and balsam of peru by using the ex vivo LLNA-BrdU method” 

22. 8th Congress of the Turkish Society of Toxicology with International Participation, November 15-18, 2012, Antalya, Turkey. “ Ulker O., Kaymak Y., Karakaya A., Investigation of contact sensitization potency of fragrance mix and fragrance mix ingredients by using ex vivo nonradioactive local lymph node assay” (Oral presentation)

23. 8th Congress of the Turkish Society of Toxicology with International Participation, November 15-18, 2012, Antalya, Turkey. “ Karakaya A., Ulker O., Ates I., Atak A., Investigation of the dermal sensitization potential of cosmetic materials by using the ex vivo local lymph node assay-BrdU”

  24. 9th Congress of the Turkish Society of Toxicology with the Participation of the Hellenic Society of Toxicology, TURKHELTOX Toxicology Congress, October 21-24 2015, Çeşme-Izmir, Turkey. “Ülker O.C., Üstündağ A., Teker E., Duydu Y., Karakaya A. Investigation of the genotoxic effects of TiO2 nanoparticles by using Ames test”

25. 9th Congress of the Turkish Society of Toxicology with the Participation of the Hellenic   Society of Toxicology, TURKHELTOX Toxicology Congress, October 21-24 2015, Çeşme- İzmir, Türkiye. “Karakaya A., Ulker Cemıloglu O., Ustundag A., Yalçın C.Ö., Duydu Y., Comparison of TiO2 nanoparticles genotoxicity in two differrent cell lines by using Comet Assay

26. 9th Congress of Toxicology in Developing Countries (9CTDC), November 7-10 2015, Natal,    Brazil. “Ulker O.C., Ustundag A., Yalçın C.O., Duydu Y, Karakaya A., Comparison of TiO2 nanoparticles genotoxicity in two different cell lines by using Comet assay.”

27. 55th Annual Meeting and ToxExpo, SOT (Society of Toxicology), March 13-17 2016, New Orleans, Louisiana, USA  “Karakaya M.A., Ulker O.C., Üstündağ A., Yalçın C.Ö., Duydu Y, In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles”

28. 52nd Congress of the European Societies of Toxicology (EUROTOX), September 4-7 2016,    Seville, Spain. “Ulker O.C., Ustundag A., Duydu Y., Yalçın C.O.,  Karakaya A. In vitro cytotoxicity and genotoxicity investigation of differently sized TiO2 nanoparticles.”

29. 52nd Congress of the European Societies of Toxicology (EUROTOX), 4-7 September 2016, Seville, Spain. “ Hogberg TH., Bouhifd M., Ulker O.C.,Rita S., Harris G., Kleensang A., Maertens A., Pamies D., Smirnova L., Zhao L., Hartung T., 3D models and omics approaches to study developmental neurotoxicity.”

30. 55th Annual Meeting and ToxExpo, SOT (Society of Toxicology), 13-17 March 2016, New    Orleans, Louisiana, USA  “Rita S. ,Ulker O.C, Simirnova L., Hartung T., Hogberg H.  Developmental neurotoxicity of flame reterdants using a rat primary three-dimensional organotypic in vitro model.”

31. 12nd International Symphosium on Pharmaceutical Sciences (ISOPS), 26-29 Haziran 2018, Ankara, Türkiye “Ulker O.C., Teker E., Ustudag A.,  Sezgin-Bayindir Z., Duydu Y., Karakaya A. Investigation of irritation effects of sunscreen formulations containing TiO2 nanoparticles by using the Epidem Skin Irritation Test”

 

 

PARTICIPATING COURSES AND WORKSHOPS

 

Workshop on Alternative Methods Reduction, Refinement, Replacement to   Animal Tests, November 12-13, Ankara, Turkey

 

CASCADE course in “Regulatory Toxicology” , August 25-29, 2008, Kuopio, Finland (course fellowship)

 

Safe Handling of cytotoxic/hazardous drugs and Laminar flow and biosafety cabinet technology course, September 29, 2011, Ankara, Turkey.

 

Developments in Risk Assessment: Basic Concepts and International Frameworks for Evaluating Toxicity Data for Human Health Risk Assessment, November 14, 2012, Antalya, Turkey.

 

Chemicals regulation in EU. REACH and CLP- Legislation and Consequences, November 15, 2012, Antalya, Turkey.

 

In vitro Skin Irritation Test according to the OECD TG 439 using reconstructed human epidermis model Epiderm (EPI-200), 19-20 July 2016, Bratislava, Slovakia

 

 

 

VISITING SCHOLAR

 

-       Johns Hopkins University, School of Public Health, Center for Alternatives to Animal Testing (CAAT), Acceptance of Prof. Dr. Thomas Hartung,  22 May 2014- 22 January 2015, supported by TUBITAK (6 months) and Johns Hopkins University Bloomberg School of Public Health (2 months)

 

-       Oklahoma State University, Department of Integrative Biology Department, Invited by Dr. Matteo Minghetti. July 2017-July 2018.

 

-       Teaching: Fall 2017-2018, Immune system toxicity, hematopoietic system toxicity, endocrine system toxicity, toxic Responses of the skin, cosmetic toxicity in Principles of Toxicology Course (Oklahoma State University-BIOL 5363)

 

Spring 2017-2018, Immunology in Physiology course (Oklahoma State University-BIOL 3204) 

 

 

 

 

MEMBERSHIPS OF SCIENTIFIC AND PROFESSIONAL COMMUNITIES

 

IUTOX (International Union of Toxicology), EUROTOX (Federation of European Toxicologists and European Societies of Toxicology), Turkish Society of Toxicology

 

ADRESS:  Ankara University, Faculty of Pharmacy, Depertment of Toxicology, 06510, Ankara, Turkey

Tel: + 90 (312) 2033126

e-mail: oulker@pharmacy.ankara.edu.tr

           

           ozge.cemiloglu@gmail.com