DR.ÖĞR.ÜYESİ IŞIL ÖZAKCA GÜNDÜZ    
Name : IŞIL
Surname : ÖZAKCA GÜNDÜZ
E-Mail :
Phone Number : 03122033139
Title : DR.ÖĞR.ÜYESİ
Unit : FACULTY OF PHARMACY
Department : DEPARTMENT OF PHARMACOLOGY
Personal Information
2002- BS. Ankara University Faculty of Pharmacy
2005- MSc. Pharmacology (Ankara University)
2011- PhD. Pharmacology (Ankara University)

Publications:

Kayki-Mutlu, G., Arioglu-Inan, E., Ozakca, I., Ozcelikay, A.T., Altan, V.M. (2014) β3-Adrenoceptor-mediated responses in diabetic rat heart. Gen Physiol Biophys33: 99-109. 

Arioglu-Inan, E., Ozakca, I., Kayki-Mutlu, G., Sepici-Dincel, A., Altan, V.M. (2013) The role of insulin-thyroid hormone interaction on β-adrenoceptor-mediated cardiac responses. Eur J Pharmacol718: 533-43. 

Ozakca, I., Arıoglu-Inan, E., Esfahani, H., Altan, V.M., Balligand, J.-L., Kaykı-Mutlu, G., Ozcelikay, A.T. (2013). Nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage. Am J Physiol Heart Circ Physiol304: H1267-76.

Basgut, B., Kayki, G., Bartosova, L., Ozakca, I., Seymen, A., Kandilci, H.B., Ugur, M., Turan, B., Ozcelikay, A.T. (2010). Cardioprotective effects of 44Bu, a newly synthesized compound, in rat heart subjected to ischemia/reperfusion injury. Eur J Pharmacol640: 117-23.

Arioglu, E., Guner, S., Ozakca, I., Altan, V.M., Ozcelikay, A.T. (2010). The changes in beta-adrenoceptor-mediated cardiac function in experimental hypothyroidism: the possible contribution of cardiac beta3-adrenoceptors. Mol Cell Biochem335: 59-66.

Ozakca, I., Arioglu, E., Guner, S, Altan, V.M., Ozcelikay, A.T. (2007). Role of beta3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats. Pharmacology80: 227-238.

Besikci-Onay, A., Guner, S., Arioglu, E., Ozakca, I., Ozcelikay, A.T., Altan, V.M. (2007). The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts. Can J Physiol Pharmacol85527-35.

 

Abstracts:

Guner, S., Ozakca, I., Kandilci, H.B., Zoto-Mustafayeva, T., Duman-Dalkilic, B., Gurdal, H. 5-Hydroxytryptamine mediated vasocontraction and Ca2+/Calmodulin and Src-kinase dependent epidermal growth factor receptor transactivation in rat aorta. The FASEB Journal 28: 1065.7, Experimental Biology 2014, San Diego, USA, April 26-30, 2014.  

Ozakca I, Altan VM, Ozcelikay AT. Nebivololün metoprolol ile karşılaştırmalı olarak sıçan papiler kas ve torakik aortasındaki etkileri. Oral presentation. 22. Ulusal Farmakoloji Kongresi, Antalya-Türkiye.  November 4-7, 2013.

Ozcelikay, A.T., Ozakca, I., Arıoglu, E., Altan, V.M. Nebivolol but not metoprolol prevents functional, morphologic and molecular abnormalities induced by isoprenaline in rat heart. 6th European Congress of Pharmacology, EPHAR 2012, Granada- Spain, July 17-20, 2012.

Arioglu-Inan, E., Ozakca, I., Kayki-Mutlu, G., Sepici-Dincel A, Altan, V.M. The possible contribution of thyroid hormones to insulin effect on beta adrenoceptor mediated cardiac responses in diabetic rats. D&CVD 2012, Paris-France, November 15-17, 2012. 

Altunkaynak, H.O., Arıoglu, E., Ozakca, I., Kaykı, G., Ozcelıkay, A.T. Increased tolerance by diabetes against ischemia/reperfusion injury in rat heart is independent from heart rate. International Symposium on New Approaches in Cardiovascular Disorders, NACD2011, Ankara-Turkey, May 4-8, 2011. 

Guner, S., Arıoglu, E., Ozakca, I., Altan, V.M. Functional consequences of diabetes-induced changes on the expression of cardiac β-adrenoceptors in rats. 4th Annual Meeting D&CVD EASD Study Group MeetingMünich-Germany, October 27-29, 2011.

Ozcelikay, A.T., Basgut, B., Kayki, G., Bartosova, L., Ozakca, I., Seymen, A., Kandilci, H.B., Ugur, M., Turan, B. Cardioprotective effects of 44Bu, a newly synthesized compound, in rat heart subjected to ischemia/reperfusion injury. ISHR 20. World Congress, Kyoto-JAPAN, May 13-16, 2010.

Kaykı, G., Arioglu, E., Ozakca, I., Ozcelikay, A.T., Altan, V.M.  (2010). The effects of diabetes on B3-adrenoceptor-mediated cardiac responses. 14th Annual Meeting of the European Council for Cardiovascular Research (ECCR), Nice-France, October 9-11, 2009.

Arıoglu, E., Guner, S., Ozakca, I., Altan, V.M., Ozcelıkay, A.T. NATO Advanced Research Workshop on Translational Knowledge for Heart Health, İstanbul-Turkey, May 12-16, 2008

Guner, S., Arioglu, E., Ozakca, I., Besikci-Onay, A., Altan, VM., Ozcelikay, AT. The Effects of Prediabetes on Responsiveness and Expression of Cardiac Beta-adrenoceptors. 2nd International Congress on Prediabetes and the Metabolic Syndrome. Barcelona-Spain, April 25-28, 2007.

Onay-Besikci, A., Guner, S., Arioglu, E., Ozakca, I., Ozcelikay, T., Altan, V.M. The effects of chronic trimetazidine treatment on mechanical parameters and fatty acid oxidation in 14 week diabetic rat hearts. Cardiac energy metabolism in Heart Failure: From Concepts To Therapies. Semiahwoo, Washington State, USA, 2006.

Guner, S., Besikci-Onay, A., Arioglu, E., Ozakca, I., Altan, VM., Ozcelıkay, AT. Substrate Metabolism and Function of Fructose-fed rat heart. Society for Heart and Vascular Metabolism. 4th Annual Metting, Semiahmoo, Washington, USA, September 6-9, 2006.

Ozakca, I., Arıoglu, E., Guner, S., Altan, V.M., Ozcelikay, A.T. Deneysel diabetik  izole gastrik fundus preparatında beta 3 adrenoseptör yanıtlarındaki değişiklikler. 18. Ulusal Farmakoloji Kongresi Özet Kitapçığı, İzmir-Türkiye, 2005.

 

Fellowship:

National Scholarship Programme for MSc Students, TUBİTAK-2210, 2002-2004

National Scholarship Programme for PhD Students, TUBİTAK-2211, 2005-2010

International Doctoral Research Fellowship Programme, TUBITAK-2214, December 2008-June 2009; “Beta adrenoceptors and cardiomyopathy in a genetic model of metabolic syndrome in mice”, Université Catholique de Louvain, IREC-FATH, Brussels, Belgium.

The European Society of Cardiology, BASIC SCIENCE SUMMER SCHOOL, 16-20 June 2013, European Heart House, Sophia Antipolis, France.

 

Projects:

Project no: TUBİTAK 114S563

 “The possible mechanisms of antihypertrophic effects of nebivolol treatment on experimental in vivo cardiac hypertrophy model” (October 2014-October 2017, 330.000 YTL, Principal Investigator). 

Project no: TUBİTAK 111S131

 “The role of epidermal growth factor receptors in serotonin receptor subtypes-mediated intracellular and vascular smooth muscle responses” (October 2011-April 2014, 116.000 YTL).

 Project no: TUBİTAK 110S179

 “The possible contribution of thyroid hormones to insülin effect on beta adrenoceptor mediated cardiac responses in diabetic rats.” (October 2010-October 2012, 171.100 YTL).

 Proje no: TUBİTAK 110S006

 “The functional and molecular effects of chronic isoprenaline infusion on rat cardiac beta adrenoceptor subtypes.” (May 2010-May 2011, 20.650 YTL).

 Proje no: TUBİTAK 106S157

 “The possible role of β-adrenoceptor subtypes on diabetes induced cardiomyopathy.” (September 2006-September 2008, 200.000 YTL).