DOÇ.DR. AYŞE SELEN ALP    
Adı : AYŞE SELEN
Soyadı : ALP
E-posta : selengurkan@gmail.com
Tel : +90 312 2033080
Ünvan : DOÇ.DR.
Birim : ECZACILIK FAKÜLTESİ
Bölüm : ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ
Kişisel Akademik Bilgiler

Ad-Soyad: A. Selen GÜRKAN-ALP
Doğum yeri ve tarihi: Mut-Mersin 1977
Medeni durumu: Evli, 2 çocuklu
Yabancı dil: İngilizce, İspanyolca (Orta düzeyde)


EĞİTİM

2001    Lisans
Ankara Üniversitesi, Eczacılık Fakültesi, Ankara
 
2004    Yüksek Lisans
Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı
 
2009    Doktora
Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı

2015    Doçentlik 
Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı


MESLEKİ DENEYİM

2002 - 2009   Araştırma Görevlisi 

2009 - 2015   Araş. Gör. Dr.  

2015 -           Doç. Dr.      

                   Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı

ÖDÜLLER

2001    Ankara Üniversitesi, Eczacılık Fakültesi 2000-2001 Mezuniyet Dönemi Birincilik Ödülü


ESERLER

A. Uluslararası hakemli dergilerde yayımlanan makaleler


1. A. Selen Gurkan, Arzu Karabay, Zeliha Buyukbingol, Adeboye Adejare, Erdem Buyukbingol, Syntheses of Novel Indole Lipoic Acid Derivatives and Their Antioxidant Effects on Lipid Peroxidation, Arch. Pharm. Chem. Life Sci., 338 (2-3); 67-73, 2005. (SCI Core Index)

DOI: 10.1002/ardp.200400932

 

2. Oya Bozdağ-Dündar, Selen Gürkan, Hassan Y. Aboul-Enein, Irena Kruk, Aleksandra Kladna, Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolylthiazolidine-2,4-dione compounds, Luminescence, 24 (3); 194-201, 2009. (SCI Core Index)

DOI: 10.1002/bio.1095

 

3. A. Selen Gurkan, Arzu Z. Karabay, Zeliha Buyukbingol, Erdem Buyukbingol, Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw264.7 macrophages, Eur. J. Med. Chem., 46 (2); 468-479, 2011. (SCI Core Index)

DOI: 10.1016/j.ejmech.2010.11.021

 

4. Gülgün Ayhan-Kılcıgil, Selen Gürkan, Tülay Çoban, Elçin Deniz Özdamar, Benay Can-Eke, Synthesis and Evaluation of Antioxidant Properties of Novel 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(2-arylmethylene amino) acetamides and 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl) acetamides-I, Chemical Biology and Drug Design, 79 (5); 869-877, 2012. (SCI Core Index)

DOI: 10.1111/j.1747-0285.2012.01347.x

 

5. A. Selen Gurkan-Alp, Mine Mumcuoglu, Cenk A. Andac, Emre Dayanc, Rengul Cetin-Atalay, Erdem Buyukbingol, Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives, Eur. J. Med. Chem., 58; 346-354, 2012. (SCI Core Index)

DOI: 10.1016/j.ejmech.2012.10.013

 

6. Net Das-Evcimen, Mutlu Sarıkaya, A. Selen Gurkan-Alp, Oya Bozdag-Dundar, Aldose reductase inhibitory potential of several thiazolyl-thiazolidine-2,4-diones, Letters in Drug Design and Discovery, 10 (5); 415-419, 2013. (SCI-Expanded)

DOI: 10.2174/1570180811310050008

 

7. Ozlem Erdas, Cenk A. Andac, A. Selen Gurkan-Alp, Ferda Nur Alpaslan, Erdem Buyukbingol, Compressed images for affinity prediction (CIFAP): a study on predicting binding affinities for checkpoint kinase 1 protein inhibitors, J. Chemometrics, 27 (6); 155-164, 2013. (SCI Core Index)

DOI: 10.1002/cem.2503

 

8. Mehlika D. Altıntop, A. Selen Gurkan-Alp, Yusuf Özkay, Zafer A. Kaplancıklı, Synthesis and Biological Evaluation of A Series of Dithiocarbamates as New Cholinesterase Inhibitors, Arch. Pharm. Chem. Life Sci., 346 (8); 571-576, 2013. (SCI Core Index)

DOI: 10.1002/ardp.201300045

 

9. A. Selen Gurkan-Alp, Hakan Göker, Mehmet Alp, Tulin Ozkan, Asuman Sunguroglu, Synthesis and anticancer effects of some novel 2-(4-phenoxyphenyl)-1H-benzimidazole derivatives on K562 cell line, Archives of Pharmacal Research, 38; 650-658, 2015(SCI-Expanded)

DOI: 10.1007/s12272-014-0438-x

 

10. Ayşe Selen Alp, Gülgün Kılcıgil, Elçin Deniz Özdamar, Tülay Çoban, Binay Eke, Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles, Turkish Journal of Chemistry, 39; 42-53, 2015. (SCI-Expanded)

DOI: 10.3906/kim-1403-44

 

11. Ozlem ERDAS, Cenk A. ANDAC, A. Selen Gurkan-Alp, Ferda Nur ALPASLAN, Erdem BUYUKBINGOL, Compressed Images for Affinity Prediction-2 (CIFAP-2): An Improved Machine Learning Methodology on Protein-Ligand Interactions Based on a Study on Caspase 3 Inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 30 (5); 809-815, 2015. (SCI Core Index)

DOI: 10.3109/14756366.2014.976566

 

12. Arzu Zeynep KARABAY, Aslı KOC, A. Selen GURKAN-ALP, Zeliha BUYUKBINGOL, Erdem BUYUKBINGOL, Inhibitory effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFNγ activated RAW 264.7 macrophages, Cell Biochemistry & Function, 33; 121-127, 2015. (SCI Core Index)                               

DOI: 10.1002/cbf.3095

 

13. Mehmet ALP, A. Selen GURKAN-ALP, Tulin OZKAN, Asuman SUNGUROGLU, Synthesis and Anticancer Evaluation of Novel 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives, Zeitschrift für Naturforschung C - A Journal of Biosciences, 70(3-4)c; 79-85, 2015. (SCI Core Index)

DOI: 10.1515/znc-2014-4189 


14.  Mine Mumcuoglu, A. Selen Gurkan-Alp, Erdem Buyukbingol, Rengul Cetin-Atalay, Retinoid N-(1H-benzo[d]imidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells, Steroids 108; 31-38, 2016. (SCI Core Index)

DOI: 10.1016/j.steroids.2016.02.008


15. Asli Koc, Tulin Ozkan, Yalda Hekmatshoar, A. Selen Gurkan-Alp, Fugen Aktan, Zeliha Buyukbingol, Asuman Sunguroglu, Erdem Buyukbingol, Arzu Zeynep Karabay, Apoptotic Effects of Some Tetrahydronaphthalene Derivatives on K562 Human Chronic Myelogenous Leukemia Cell Line, Anti-Cancer Agents in Medicinal Chemistry, 17, 1924-1930, 2017. (SCI-Expanded)

DOI: 10.2174/1871521409666170412122811

 

B. Ulusal hakemli dergilerde yayımlanan makaleler

1. A. Selen Gürkan, Oya Bozdağ-Dündar, Coenzyme Q10, Ankara Ecz. Fak. Derg., 34(2); 129-154 pp., 2005.

http://dergiler.ankara.edu.tr/dergiler/24/524/6567.pdf

2. A. Selen Gurkan-Alp, Erdem Buyukbingol, "Bazı Retinoidal Bileşiklerin RXRa Proteinine Doking Çalışmaları", Ankara Ecz. Fak. Derg., 38(3); 155-166 pp., 2009. (accepted: 06.03.2012

http://dergiler.ankara.edu.tr/dergiler/24/1716/18323.pdf

 

C. Kitap Bölümü

1.  A. Selen Gurkan, Erdem Buyukbingol, "Novel Indole Lipoic Acid Derivatives: Synthesis and Their Antioxidant Effects." in: Lipoic Acid. Energy Production, Antioxidant Activity and Health Effects., Mulchand S. PATEL and Lester PACKER, eds., CRC Press, Taylor & Francis Group, 85-98 pp., 2008.  ISBN: 4200-4537-7.

 

D. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında basılan bildiriler

1.  A. Selen Gurkan, Arzu Karabay, Zeliha Buyukbingol, Adeboye Adejare, Erdem Buyukbingol, "Syntheses and Antioxidant Effects on Lipid Peroxidation of Novel Indole Lipoic Acid Derivatives", 362 pp. (2-PO49), 20th International Congress of Heterocyclic Chemistry (20th-ICHC), Palermo, Italya, 31 Temmuz - 5 Ağustos 2005.

2.  A. Selen Gurkan, Dilek Yonar, Erdem Buyukbingol, "Synthesis and Structural Elucidation by Electron Paramagnetic Resonance (EPR) Spectroscopy of a Novel Retinoidal Nitroxide Derivative: 5,5,8,8-Tetramethyl-N-(2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide", 238 pp. (P-116), 9th International Symposium on Pharmaceutical Sciences (ISOPS-9), Ankara, Türkiye, 23-26 Haziran 2009.

3.   A. Selen Gurkan, Arzu Karabay, Zeliha Buyukbingol, Erdem Buyukbingol, "Effects of Some Novel Tetrahydronaphthalene Derivatives on Proliferation and Nitric Oxide Production in Lipopolysaccharide Activated Raw264.7 Macrophages", 239 pp. (P-117), 9th International Symposium on Pharmaceutical Sciences (ISOPS-9), Ankara, Türkiye, 23-26 Haziran 2009.

4.  Oya Bozdağ-Dündar, Selen Gürkan, Eugen J. Verspohl, Elisabeth Hüppe,  Mira König, "Synthesis and Antidiabetic Activity of Some New Thiazolyl Thiazolidine-2,4-Dione Derivatives", 114 pp. (SL14), International Conference on Medicinal Chemistry (RICT-45). Drug Discovery and Selection, Orleans, Fransa, 1-3 Temmuz 2009.

5.  A. Selen Gurkan, Zeynep Ates-Alagoz, Erdem Buyukbingol, "Synthesis and Structural Elucidation of Some Novel Tetrahydronaphthalene Derivatives as Retinoid Analogues", 131 pp. (SL31), International Conference on Medicinal Chemistry (RICT-45). Drug Discovery and Selection, Orleans, Fransa, 1-3 Temmuz 2009.

6.    Gülgün Ayhan-Kılcıgil, Selen Gürkan, Tülay Çoban, Elçin Deniz Özdamar, Benay Can-Eke, "Synthesis and Evaluation of Antioxidant Properties of Some 2-[2-(4-chlorophenyl)benzimidazol-1-yl]-N-(4-oxo-2-substitutedphenyl-thiazolidin-3-yl) acetamides", 176 pp. (P092), 3rd European Conference on Chemistry for Life Sciences: Linking Chemistry with Biological Activity, Frankfurt am Main, Almanya, 2-5 Eylül 2009.

7.    A. Selen Gurkan, Erdem Buyukbingol, "Synthesis of some novel indole retinoid derivatives as potential antitumor agents", (Medicinal Chemistry and Agrochemicals - 343), 18th International Conference on Organic Synthesis (ICOS-18), Bergen, Norveç, 1-6 Ağustos 2010.

8.  Mine Mumcuoglu, A. Selen Gurkan-Alp, Rengul Atalay, Erdem Buyukbingol, "Novel retinoid derivatives against breast cancer", 205 pp. (P092), 4th International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC11), St. Petersburg, Rusya, 21-25 Ağustos 2011.

9.   Zubeyir Elmazoglu, A. Selen Gurkan-Alp, Erdem Buyukbingol, "Synthesis of some novel N-substituted farnesylthiosalicylamide derivatives", 192 pp. (P50), 4th European Conference on Chemistry for Life Sciences (4ECCLS), Budapeşte, Macaristan, 31 Ağustos - 3 Eylül 2011.

10.  Asli Demirci, A. Selen Gurkan-Alp, Erdem Buyukbingol, "Synthesis of some novel N-substituted 3-trans,trans-farnesylthiobenzamide derivatives as potential anticancer agents", 161 pp. (P-86), 10th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara, Türkiye, 26-29 Haziran 2012.

11.  A. Selen Gurkan-Alp, Gülgün Ayhan-Kılcıgil, Elçin Deniz Özdamar, Tülay Çoban, Benay Can-Eke, "Synthesis and evaluation of antioxidant activities of novel 2-(substitutedbenzylthio)-5-((2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles", 162 pp. (P-87), 10th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara, Türkiye, 26-29 Haziran 2012.

12. Ozlem Erdas, Cenk Andac, Selen Gurkan-Alp, Ferda Nur Alpaslan, Erdem Buyukbingol, "Predicting binding affinities of drug-protein interactions by analysis of binding site images", 50 pp. (Sözlü sunum OP-8), 10th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara, Türkiye, 26-29 Haziran 2012.

13.  Asli Demirci, A. Selen Gurkan-Alp, Erdem Buyukbingol, "Synthesis of some novel N-substituted 4-trans,trans-farnesylthiobenzamide derivatives as potential anticancer agents", 162 pp. (P-115), 13th Belgian Organic Synthesis Symposium (BOSS XIII), Leuven, Belçika, 15-20 Temmuz 2012.

14.  Erdem Buyukbingol, Ozlem Erdas, Cenk A. Andac, Selen Gurkan-Alp, Ferda Nur Alparslan, Compressed Images for Affinity Prediction (CIFAP): A Novel Machine Learning Methodology on Protein-Ligand Interactions, Sözlü sunum, International Conference on Omics Studies, Orlando-FL, USA, 4-5 Eylül 2013. Journal of Proteomics & Bioinformatics, 6:8, 48 (2013).  ISSN: 0974-276X             http://omicsonline.org/0974-276X/0974-276X-S1.002-021.pdf

15.  Ozlem Erdas, Cenk A. Andac, A. Selen Gurkan-Alp, Ferda Nur Alparslan, Erdem Buyukbingol, Compressed Images for Affinity Prediction (CIFAP): A Novel Machine Learning Methodology on Protein-Ligand Interactions, Sözlü sunum 31 pp. (IL-20), 2nd International BAU-Drug Design Symposium, Bahçeşehir Üniversitesi, İstanbul, Türkiye. 17-19 Nisan 2014.

16.  A. Selen Gurkan-Alp, Gülgün Ayhan-Kılcıgil, Elçin Deniz Özdamar, Tülay Çoban, Benay Can-Eke, Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles, 20th International Conference on Organic Synthesis (ICOS-20), Budapeşte, Macaristan, 29 Haziran-4 Temmuz 2014.

17.  A.Z. Karabay, A. Koc, S. Gurkan, Z. Buyukbingol, E. Buyukbingol, Effects of indole a-lipoic acid derivatives on nitric oxide production in LPS/IFN-g activated RAW 264.7 macrophages, FEBS EMBO Conference, 30 Ağustos-4 Eylül 2014, Paris, France. Special Issue: The FEBS Journal, 281 (Suppl. 1),  CSI-02–Inflammation & Disease, 120 pp. (SUN- 159), 2014.                                                                                                          http://onlinelibrary.wiley.com/doi/10.1111/febs.12919/abstract

18. Arzu Z. Karabay, Aslı Koc, A. Selen Gurkan-Alp, Zeliha Buyukbingol, Erdem Buyukbingol, Effects of indole α-lipoic acid derivatives on cell viability parameters in K562 leukemia cell line, Symposium on Pharmaceutical Sciences (ISOPS-11), 43 pp. (OP-14), Ankara, Türkiye, 09-12 Haziran 2015.

19. Mehmet Alp, A. Selen Gurkan-Alp, Tulin Ozkan, Asuman Sunguroglu, Anticancer evaluation of Some 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives, International Symposium on Pharmaceutical Sciences (ISOPS-11), 289 pp. (P228), Ankara, Türkiye, 09-12 Haziran 2015. 

20. M. Gok, A.S. Gurkan-Alp, E. Buyukbingol, E. Bodur, Effect of retinoid derivates on cholinesterase activity, 42nd FEBS Congress, Kudüs, İsrail, 10-14 Eylül 2017Special Issue: The FEBS Journal, 284 (Suppl. 1), 327 pp. (P. 5. 2-014), 2017     http://onlinelibrary.wiley.com/doi/10.1111/febs.14174/epdf 

21. Mehmet Alp, A. Selen Gurkan-Alp, Arzu Z. Karabay, Erdem Buyukbingol, Synthesis and anticancer effects of some novel benzimidazole-derived PARP inhibitor molecules, 2nd International Gazi Pharma Symposium Series (GPSS-2017), 272 pp, (P203), Ankara, Türkiye, 11-13 Ekim 2017.

22. A. Selen Gurkan-Alp, Asli Koc, Arzu Z. Karabay, Erdem Buyukbingol, Synthesis and Anticancer Activity Studies of Some Novel Indole Retinoid Derivatives, International Symposium on Pharmaceutical Sciences (ISOPS-12), 399 pp. (P-479), Ankara, Türkiye, 26-29 Haziran 2018.

23. A. Selen Gurkan-Alp, İsmail Çelik, Gülgün Ayhan-Kılcıgil, Molecular Docking Studies of Some Novel Benzimidazole Derivatives as EGFR Inhibitors, International Symposium on Pharmaceutical Sciences (ISOPS-12), 400 pp. (P-480), Ankara, Türkiye, 26-29 Haziran 2018


E. Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler

1. Selen Gurkan, Erdem Buyukbingol, "Yeni Retinoid Bileşiklerinin Tasarlanması, Sentezi, Yapı Aydınlatılması, Biyolojik Etki Tayini ve Yapı-Aktivite Çalışmaları", 9 pp. (Sözlü sunum-8), 2. Ulusal Farmasötik Kimya Kongresi, Mersin, Türkiye, 13-15 Kasım 2009. 

2. Cenk A. Andaç, Dilan Konyar, Selen Gürkan-Alp, Ningur Noyanalpan, Erdem Büyükbingöl, Mdm2-P53 Etkileşimini İnhibe Edecek Antikanser Etkili Yeni Spiro-Oksiindol Türevleri, 27. Ulusal Kimya Kongresi, 499 pp. (Sözlü sunum S-İL015), Çanakkale, Türkiye, 23-28 Ağustos 2015.