ACADEMIC DEGREES

2001    B.Sc  Ankara University, Faculty of Pharmacy, Ankara

2004    M.Sc  Ankara University, Faculty of Pharmacy, Department of                                        Pharmaceutical Chemistry

2009    Ph.D  Ankara University, Faculty of Pharmacy, Department                                           of Pharmaceutical Chemistry

2015    Associate Professor   Ankara University, Faculty of Pharmacy, Department of                                        Pharmaceutical Chemistry

EMPLOYMENT HISTORY

2002 - 2015  Research Assistant                                                                     

2015-           Associate Professor      

AWARDS

2001  Graduation from Ankara University, Faculty of Pharmacy, First Place

PUBLICATIONS

A. Articles in Refereed International Journals

1. A. Selen Gurkan, Arzu Karabay, Zeliha Buyukbingol, Adeboye Adejare, Erdem Buyukbingol, Syntheses of Novel Indole Lipoic Acid Derivatives and Their Antioxidant Effects on Lipid Peroxidation, Arch. Pharm. Chem. Life Sci., 338 (2-3); 67-73, 2005. (SCI Core Index)

DOI: 10.1002/ardp.200400932

2. Oya Bozdağ-Dündar, Selen Gürkan, Hassan Y. Aboul-Enein, Irena Kruk, Aleksandra Kladna, Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolylthiazolidine-2,4-dione compounds, Luminescence, 24 (3); 194-201, 2009. (SCI Core Index)

DOI: 10.1002/bio.1095

3. A. Selen Gurkan, Arzu Z. Karabay, Zeliha Buyukbingol, Erdem Buyukbingol, Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw264.7 macrophages, Eur. J. Med. Chem., 46 (2); 468-479, 2011. (SCI Core Index)

DOI: 10.1016/j.ejmech.2010.11.021

4. Gülgün Ayhan-Kılcıgil, Selen Gürkan, Tülay Çoban, Elçin Deniz Özdamar, Benay Can-Eke, Synthesis and Evaluation of Antioxidant Properties of Novel 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(2-arylmethylene amino) acetamides and 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl) acetamides-I, Chemical Biology and Drug Design, 79 (5); 869-877, 2012. (SCI Core Index)

DOI: 10.1111/j.1747-0285.2012.01347.x

5. A. Selen Gurkan-Alp, Mine Mumcuoglu, Cenk A. Andac, Emre Dayanc, Rengul Cetin-Atalay, Erdem Buyukbingol, Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives, Eur. J. Med. Chem., 58; 346-354, 2012. (SCI Core Index)

DOI: 10.1016/j.ejmech.2012.10.013

6. Net Das-Evcimen, Mutlu Sarıkaya, A. Selen Gurkan-Alp, Oya Bozdag-Dundar, Aldose reductase inhibitory potential of several thiazolyl-thiazolidine-2,4-diones, Letters in Drug Design and Discovery, 10 (5); 415-419, 2013. (SCI-Expanded)

DOI: 10.2174/1570180811310050008

7. Ozlem Erdas, Cenk A. Andac, A. Selen Gurkan-Alp, Ferda Nur Alpaslan, Erdem Buyukbingol, Compressed images for affinity prediction (CIFAP): a study on predicting binding affinities for checkpoint kinase 1 protein inhibitors, J. Chemometrics, 27 (6); 155-164, 2013. (SCI Core Index)

DOI: 10.1002/cem.2503

8. Mehlika D. Altıntop, A. Selen Gurkan-Alp, Yusuf Özkay, Zafer A. Kaplancıklı, Synthesis and Biological Evaluation of A Series of Dithiocarbamates as New Cholinesterase Inhibitors, Arch. Pharm. Chem. Life Sci., 346 (8); 571-576, 2013. (SCI Core Index)

DOI: 10.1002/ardp.201300045

9. A. Selen Gurkan-Alp, Hakan Göker, Mehmet Alp, Tulin Ozkan, Asuman Sunguroglu, Synthesis and anticancer effects of some novel 2-(4-phenoxyphenyl)-1H-benzimidazole derivatives on K562 cell line, Archives of Pharmacal Research, 38; 650-658, 2015. (SCI-Expanded)

DOI: 10.1007/s12272-014-0438-x

10. Ayşe Selen Alp, Gülgün Kılcıgil, Elçin Deniz Özdamar, Tülay Çoban, Binay Eke, Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles, Turkish Journal of Chemistry, 39; 42-53, 2015. (SCI-Expanded)

DOI: 10.3906/kim-1403-44

11. Ozlem ERDAS, Cenk A. ANDAC, A. Selen Gurkan-Alp, Ferda Nur ALPASLAN, Erdem BUYUKBINGOL, Compressed Images for Affinity Prediction-2 (CIFAP-2): An Improved Machine Learning Methodology on Protein-Ligand Interactions Based on a Study on Caspase 3 Inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 30 (5); 809-815, 2015. (SCI Core Index)

DOI: 10.3109/14756366.2014.976566

12. Arzu Zeynep KARABAY, Aslı KOC, A. Selen GURKAN-ALP, Zeliha BUYUKBINGOL, Erdem BUYUKBINGOL, Inhibitory effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFNγ activated RAW 264.7 macrophages, Cell Biochemistry & Function, 33; 121-127, 2015. (SCI Core Index) 

DOI: 10.1002/cbf.3095

13. Mehmet ALP, A. Selen GURKAN-ALP, Tulin OZKAN, Asuman SUNGUROGLU, Synthesis and Anticancer Evaluation of Novel 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives, Zeitschrift für Naturforschung C - A Journal of Biosciences, 70(3-4)c; 79-85, 2015. (SCI Core Index)

DOI: 10.1515/znc-2014-4189 

14.  Mine Mumcuoglu, A. Selen Gurkan-Alp, Erdem Buyukbingol, Rengul Cetin-Atalay, Retinoid N-(1H-benzo[d]imidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells, Steroids 108; 31-38, 2016. (SCI Core Index)

DOI: 10.1016/j.steroids.2016.02.008

15. Asli Koc, Tulin Ozkan, Yalda Hekmatshoar, A. Selen Gurkan-Alp, Fugen Aktan, Zeliha Buyukbingol, Asuman Sunguroglu, Erdem Buyukbingol, Arzu Zeynep Karabay, Apoptotic Effects of Some Tetrahydronaphthalene Derivatives on K562 Human Chronic Myelogenous Leukemia Cell Line, Anti-Cancer Agents in Medicinal Chemistry, 17; 1924-1930, 2017. (SCI-Expanded)

DOI: 10.2174/1871521409666170412122811

B. Articles in Refereed National Journals

1. A. Selen Gürkan, Oya Bozdağ-Dündar, Coenzyme Q₁₀, J. Fac. Pharm. Ankara, 34(2); 129-154 pp., 2005.

http://dergiler.ankara.edu.tr/dergiler/24/524/6567.pdf 

2. A. Selen Gurkan-Alp, Erdem Buyukbingol, "Docking Studies of Some Retinoidal Compounds to Rxrα Protein", J. Fac. Pharm. Ankara, 38(3); 155-166 pp., 2009. (accepted: 06.03.2012) 

http://dergiler.ankara.edu.tr/dergiler/24/1716/18323.pdf

C. Book Chapter

1.  A. Selen Gurkan, Erdem Buyukbingol, "Novel Indole Lipoic Acid Derivatives: Synthesis and Their Antioxidant Effects." in: Lipoic Acid. Energy Production, Antioxidant Activity and Health Effects., Mulchand S. PATEL and Lester PACKER, eds., CRC Press, Taylor & Francis Group, 85-98 pp., 2008. ISBN: 4200-4537-7.

D. Published Conference Abstracts

1.  A. Selen Gurkan, Arzu Karabay, Zeliha Buyukbingol, Adeboye Adejare, Erdem Buyukbingol, "Syntheses and Antioxidant Effects on Lipid Peroxidation of Novel Indole Lipoic Acid Derivatives", 362 pp. (2-PO49), 20^th International Congress of Heterocyclic Chemistry (20^th-ICHC), Palermo, Italy, 31 July - 5 August 2005.

2.  A. Selen Gurkan, Dilek Yonar, Erdem Buyukbingol, "Synthesis and Structural Elucidation by Electron Paramagnetic Resonance (EPR) Spectroscopy of a Novel Retinoidal Nitroxide Derivative: 5,5,8,8-Tetramethyl-N-(2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide", 238 pp. (P-116), 9^th International Symposium on Pharmaceutical Sciences (ISOPS-9), Ankara, Turkey, 23-26 June 2009.

3.   A. Selen Gurkan, Arzu Karabay, Zeliha Buyukbingol, Erdem Buyukbingol, "Effects of Some Novel Tetrahydronaphthalene Derivatives on Proliferation and Nitric Oxide Production in Lipopolysaccharide Activated Raw264.7 Macrophages", 239 pp. (P-117), 9^th International Symposium on Pharmaceutical Sciences (ISOPS-9), Ankara, Turkey, 23-26 June 2009.

4.  Oya Bozdağ-Dündar, Selen Gürkan, Eugen J. Verspohl, Elisabeth Hüppe,  Mira König, "Synthesis and Antidiabetic Activity of Some New Thiazolyl Thiazolidine-2,4-Dione Derivatives", 114 pp. (SL14), International Conference on Medicinal Chemistry (RICT-45). Drug Discovery and Selection, Orleans, France, 1-3 July 2009.

5.  A. Selen Gurkan, Zeynep Ates-Alagoz, Erdem Buyukbingol, "Synthesis and Structural Elucidation of Some Novel Tetrahydronaphthalene Derivatives as Retinoid Analogues", 131 pp. (SL31), International Conference on Medicinal Chemistry (RICT-45). Drug Discovery and Selection, Orleans, France, 1-3 July 2009.

6.   Gülgün Ayhan-Kılcıgil, Selen Gürkan, Tülay Çoban, Elçin Deniz Özdamar, Benay Can-Eke, "Synthesis and Evaluation of Antioxidant Properties of Some 2-[2-(4-chlorophenyl)benzimidazol-1-yl]-N-(4-oxo-2-substitutedphenyl-thiazolidin-3-yl)acetamides", 176 pp. (P092), 3^rd European Conference on Chemistry for Life Sciences: Linking Chemistry with Biological Activity, Frankfurt am Main, Germany, 2-5 September 2009.

7.   A. Selen Gurkan, Erdem Buyukbingol, "Synthesis of some novel indole retinoid derivatives as potential antitumor agents", (Medicinal Chemistry and Agrochemicals - 343), 18^th International Conference on Organic Synthesis (ICOS-18), Bergen, Norway, 1-6 August 2010.

8. Mine Mumcuoglu, A. Selen Gurkan-Alp, Rengul Atalay, Erdem Buyukbingol, "Novel retinoid derivatives against breast cancer", 205 pp. (P092), 4^th International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC11), St. Petersburg, Russia, 21-25 August 2011.

9.   Zubeyir Elmazoglu, A. Selen Gurkan-Alp, Erdem Buyukbingol, "Synthesis of some novel N-substituted farnesylthiosalicylamide derivatives", 192 pp. (P50), 4^th European Conference on Chemistry for Life Sciences (4ECCLS), Budapest, Hungary, 31 August - 3 September 2011.

10.  Asli Demirci, A. Selen Gurkan-Alp, Erdem Buyukbingol, "Synthesis of some novel N-substituted 3-trans,trans-farnesylthiobenzamide derivatives as potential anticancer agents", 161 pp. (P-86), 10^th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara, Turkey, 26-29 June 2012. 

11.  A. Selen Gurkan-Alp, Gülgün Ayhan-Kılcıgil, Elçin Deniz Özdamar, Tülay Çoban, Benay Can-Eke, "Synthesis and evaluation of antioxidant activities of novel 2-(substitutedbenzylthio)-5-((2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles", 162 pp. (P-87), 10^th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara, Turkey, 26-29 June 2012.

12. Özlem Erdas, Cenk Andac, Selen Gurkan-Alp, Ferda Nur Alpaslan, Erdem Buyukbingol, "Predicting binding affinities of drug-protein interactions by analysis of binding site images", 50 pp. (OP-8), 10^th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara, Turkey, 26-29 June 2012.

13.  Asli Demirci, A. Selen Gurkan-Alp, Erdem Buyukbingol, "Synthesis of some novel N-substituted 4-trans,trans-farnesylthiobenzamide derivatives as potential anticancer agents", 162 pp. (P-115), 13^th Belgian Organic Synthesis Symposium (BOSS XIII), Leuven, Belgium, 15-20 July 2012.

14.  Erdem Buyukbingol, Ozlem Erdas, Cenk A. Andac, Selen Gurkan-Alp, Ferda Nur Alparslan, Compressed Images for Affinity Prediction (CIFAP): A Novel Machine Learning Methodology on Protein-Ligand Interactions, Oral presentation, International Conference on Omics Studies, Orlando-FL, USA, 4-5 September 2013. Journal of Proteomics & Bioinformatics, 6:8, 48 (2013).  ISSN: 0974-276X http://omicsonline.org/0974-276X/0974-276X-S1.002-021.pdf

15.  Ozlem Erdas, Cenk A. Andac, A. Selen Gurkan-Alp, Ferda Nur Alparslan, Erdem Buyukbingol, "Compressed Images for Affinity Prediction (CIFAP): A Novel Machine Learning Methodology on Protein-Ligand Interactions", Oral presentation IL-20 (31 pp), 2nd International BAU-Drug Design Symposium, Bahçeşehir University, İstanbul, Turkey, 17-19 April 2014.

16.  A. Selen Gurkan-Alp, Gülgün Ayhan-Kılcıgil, Elçin Deniz Özdamar, Tülay Çoban, Benay Can-Eke, Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles, 20^th International Conference on Organic Synthesis (ICOS-20), Budapest, Hungary, 29 June-4 July 2014. 

17. A.Z. Karabay, A. Koc, S. Gurkan, Z. Buyukbingol, E. Buyukbingol, Effects of indole a-lipoic acid derivatives on nitric oxide production in LPS/IFN-g activated RAW 264.7 macrophages, FEBS EMBO Conference, 30 August-4 September 2014, Paris, France. Special Issue: The FEBS Journal, 281 (Suppl. 1),  CSI-02–Inflammation & Disease, 120 pp. (SUN- 159), 2014.                                                http://onlinelibrary.wiley.com/doi/10.1111/febs.12919/abstract 

18. Arzu Z. Karabay, Aslı Koc, A. Selen Gurkan-Alp, Zeliha Buyubingol, Erdem Buyukbingol, Effects of indole α-lipoic acid derivatives on cell viability parameter in K562 leukemia cell line, Symposium on Pharmaceutical Sciences (ISOPS-11), 43   pp. (OP-14), Ankara, Turkey, 09-12 June 2015.

19. Mehmet Alp, A. Selen Gurkan-Alp, Tulin Ozkan, Asuman Sunguroglu, Anticancer   evaluation of Some 5-(4-Methylpiperazin-1-yl)-2-Phenyl-1H-Benzimidazole Derivatives,  International Symposium on Pharmaceutical Sciences (ISOPS-11), 289 pp. (P228),       Ankara, Turkey, 09-12 June 2015.