PROF.DR. SİBEL SÜZEN    
Name : SİBEL
Surname : SÜZEN
E-Mail : sibel2264@gmail.com
Phone Number : 2033074
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : Pharmaceutical Chemistry
Personal Information

BIOGRAPHY

She was born in İstanbul in 1964, graduated from Ankara University, Faculty of Pharmacy, in 1985. After completing her master’s degree at the same University in 1989, took the title of doctor in 1997 in University of Wales-Swansea, UK, Chemistry Department.  She became an Assistant Professor in 2000 in Ankara University Faculty of pharmacy, Department of Pharmaceutical Chemistry. Then Associate Professor in 2002 and got the title of Professor in 2008 in the same Department. She visited University of Wales-Swansea, Chemistry Department many times for postdoctoral studies. She was a member of the Executive Committee of Turkish pharmaceutical and medicinal chemistry Association (2003-2009) and a member of the Faculty Board of pharmacy Faculty (2006-2008). She was Socrates-Erasmus Programme Coordinator of Pharmacy Faculty (2009- ). Currently, she is a commission member of European Pharmacopoeia EDQM 10D Group (semi-synthetic and synthetic substances). She carried out a large number of projects supported by TUBITAK and University resources. She has many book chapters and publications. She has several editorial board memberships of journals and organized many conferences. Currently, she is a professor at Faculty of Pharmacy, Department of pharmaceutical chemistry. She is EU Educational Programmes and Institutional Erasmus Coordinator, Internationalisation and International Students Coordinator of Ankara University. 


International Publications  (SCI / SCI expanded)

 Suzen, S. Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anticancer Activity (2017) Curr Org Chem. In press.

 Gurer-Orhan H, Ince E, Konyar D, Saso L, Suzen S. The Role of Oxidative Stress Modulators In Breast Cancer. (2017) Curr Med Chem.  [Epub ahead of print]

 Suzen S, Gurer-Orhan H, Saso L. Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique. (2017) Molecules. 22(1), pii: E181.

 Shirinzadeh H, Ince E, Westwell AD, Gurer-Orhan H, Suzen S. Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities.(2016) J Enzyme Inhib Med Chem. 31(6),1312-21.

 Gurer-Orhan H, Karaaslan C, Ozcan S,  Firuzi O, Tavakkoli M, Saso L, Suzen S. Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage. (2016) Bioorg Med Chem. 24(8):1658-64

 El-Sayed Mt,  Zoraghı R, Reıner N, Suzen S,  Ohlsen K, Altanlar N, Hılgeroth A.  Novel inhibitors of the MRSA-pyruvate kinase. (2016) J Enzyme Inh Med Chem.,  31(6):1666-71

 El-Sayed Mt, Suzen S, Altanlar N, Ohlsen K, Hılgeroth A. Discovery of Bisindolyl-Substituted Cycloalkane-Anellated Indoles as Novel Class of Antibacterial Agents against S. aureus and MRSA. (2016) Bioorg Med Chem Lett. 26(1), 218-21.

 Püsküllü, M.O., Shirinzadeh, H., Nenni, M., Gurer-Orhan, H., Suzen, S. Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: Bioisosteric Melatonin Analogues. (2016) J Enzyme Inh Med Chem, 31(1):121-5.

 Gurer-Orhan H, Suzen S. Melatonin, its metabolites and its synthetic analogs as multi-faceted compounds: antioxidant, prooxidant and inhibitor of bioactivation reactions. (2015) Curr Med Chem. 22(4), 490-9.

 Karaaslan C, Suzen S. Antioxidant properties of melatonin and its potential action in diseases. (2015) Curr Top Med Chem. 15(9), 894-903.

 Suzen S, Saso L. Antioxidant heterocyclic compounds in drug discovery and medicinal chemistry. (2013) Mini Rev Med. Chem, 13(3), 317,

 Tekiner-Gulbas, B., Westwell, A.D., Suzen, S. Oxidative stress in carcinogenesis: New synthetic compounds with dual effects upon free radicals and cancer. (2013) Curr Med Chem, 20 (36), pp. 4451-4459.

 Suzen, S., Tekiner-Gulbas, B., Shirinzadeh, H., Uslu, D., Gurer-Orhan, H., Gumustas, M., Ozkan, S.A. Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization (2013) J Enzyme Inh Med Chem, 28 (6), pp. 1143-1155.

 Püsküllü, M.O., Tekiner, B., Suzen, S. Recent studies of antioxidant quinoline derivatives (2013) Mini-Rev Med Chem, 13 (3), pp. 365-372.

 Karaaslan, C., Kadri, H., Coban, T., Suzen, S., Westwell, A.D. Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles (2013) Bioorg Med Chem Lett, 23 (9), pp. 2671-2674.

 Suzen, S. Melatonin and synthetic analogs as antioxidants. (2013) Current Drug Delivery, 10 (1), pp. 71-75.

 Yilmaz, A.D., Coban, T., Suzen, S. Synthesis and antioxidant activity evaluations of melatonin-based analogue indole-hydrazide/hydrazone derivatives (2012) Journal of Enzyme Inhibition and Medicinal Chemistry, 27 (3), pp. 428-436.

 Suzen, S., Cihaner, S.S., Coban, T. Synthesis and comparison of antioxidant properties of indole-based melatonin analogue indole amino acid derivatives (2012) Chemical Biology and Drug Design, 79 (1), pp. 76-83.

 Shirinzadeh, H., Altanlar, N., Yucel, N., Ozden, S., Suzen, S. Antimicrobial evaluation of indole-containing hydrazone derivatives (2011) Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 66 C (7-8), pp. 340-344.

 Das-Evcimen, N., Sarikaya, M., Gurkok, G., Suzen, S. Evaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivatives (2011) Medicinal Chemistry Research, 20 (4), pp. 453-460.

 Yuksel, N., Baykara, M., Shirinzade, H., Suzen, S. Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies (2011) International Journal of Pharmaceutics, 404 (1-2), pp. 102-109.

 Suzen, S., Ozkan, S.A. Combination of electrochemical, spectrometric and other analytical techniques for high throughput screening of pharmaceutically active compounds (2010) Combinatorial Chemistry and High Throughput Screening, 13 (7), pp. 658-664.

 Shirinzadeh, H., Yilmaz, A.D., Gumustas, M., Suzen, S., Ozden, S., Ozkan, S.A. Electrochemical behavior of indole-3-carboxaldehyde izonicotinoyl hydrazones: Discussion on possible biological behavior (2010) Combinatorial Chemistry and High Throughput Screening, 13 (7), pp. 619-627.

 Shirinzadeh, H., Eren, B., Gurer-Orhan, H., Suzen, S., Özden, S. Novel indole-based analogs of melatonin: Synthesis and in vitro antioxidant activity studies (2010) Molecules, 15 (4), pp. 2187-2202.

 Daş-Evcimen, N., Yildirim, O., Suzen, S. Relationship between aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives (2009) Archives of Biological Sciences, 61 (4), pp. 675-681.

 Ferreira, P.M., Monteiro, L.S., Coban, T., Suzen, S. Comparative effect of N-substituted dehydroamino acids and alpha-tocopherol on rat liver lipid peroxidation activities. (2009) Journal of enzyme inhibition and medicinal chemistry, 24 (4), pp. 967-971.

 Gürkök, G., Coban, T., Suzen, S. Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: Synthesis and structureactivity relationships (2009) Journal of Enzyme Inhibition and Medicinal Chemistry, 24 (2), pp. 506-515.

 Gurkok, G., Altanlar, N., Suzen, S. Investigation of antimicrobial activities of indole-3-aldehyde hydrazide/hydrazone derivatives (2009) Chemotherapy, 55 (1), pp. 15-19.

 Çalişkan-Ergün, B., Şüküroǧlu, M., Coban, T., Banoǧlu, E., Suzen, S. Screening and evaluation of antioxidant activity of some pyridazine derivatives (2008) Journal of Enzyme Inhibition and Medicinal Chemistry, 23 (2), pp. 225-229.

 Suzen, S., Das-Evcimen, N., Varol, P., Sarikaya, M. Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: Affiliation to antioxidant activity (2007) Medicinal Chemistry Research, 16 (3), pp. 112-118.

 Şüküroǧlu, M., Çalişkan-Ergün, B., Das-Evcimen, N., Sarikaya, M., Banoǧlu, E., Suzen, S. Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives (2007) Medicinal Chemistry Research, 15 (7-8), pp. 443-451.

 Suzen, S., Bozkaya, P., Coban, T., Nebioǧlu, D. Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: Discussion on possible antioxidant mechanisms and comparison with melatonin (2006) Journal of Enzyme Inhibition and Medicinal Chemistry, 21 (4), pp. 405-411.

 Suzen, S. Recent developments of melatonin related antioxidant compounds (2006) Combinatorial Chemistry and High Throughput Screening, 9 (6), pp. 409-419.

 Suzen, S., Gurkok, G., Coban, T. Novel N-acyl dehydroalanine derivatives as antioxidants: Studies on rat liver lipid peroxidation levels and DPPH free radical scavenging activity (2006) Journal of Enzyme Inhibition and Medicinal Chemistry, 21 (2), pp. 179-185.

 Gurer-Orhan, H., Orhan, H., Suzen, S., Püsküllü, M.O., Buyukbingol, E. Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives (2006) Journal of Enzyme Inhibition and Medicinal Chemistry, 21 (2), pp. 241-247.

 Ateş-Alagöz, Z., Coban, T., Suzen, S. A comparative study: Evaluation of antioxidant activity of melatonin and some indole derivatives (2005) Medicinal Chemistry Research, 14 (3), pp. 169-179.

 Kaymakçioǧlu, B.K., Aktan, Y., Süzen, S., Gökhan, N., Koyunoǧlu, S., Erol, K., Yeşilada, A., Rollas, S. In vivo metabolism of 2-[1′-phenyl-3′-(3-chlorophenyl)- 2′-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone in rats (2005) European Journal of Drug Metabolism and Pharmacokinetics, 30 (4), pp. 255-260.

 Dogan, B., Uslu, B., Suzen, S., Ozkan, S.A. Electrochemical evaluation of nucleoside analogue lamivudine in pharmaceutical dosage forms and human serum (2005) Electroanalysis, 17 (20), pp. 1886-1894.

 Suzen, S., Buyukbingol, E. Recent studies of aldose reductase enzyme inhibition for diabetic complications (2003) Current Medicinal Chemistry, 10 (15), pp. 1329-1352.

 Süzen, S., Demírcígíl, B.T., Buyukbingol, E., Özkan, S.A. Electroanalytical evaluation and determination of 5-(3′-indolyl)-2-thiohydantoin derivatives by voltammetric studies: Possible relevance to in vitro metabolism (2003) New Journal of Chemistry, 27 (6), pp. 1007-1011.

 Süzen, S., Ateş-Alagöz, Z., Demircigil, B.T., Özkan, S.A. Synthesis and analytical evaluation by voltammetric studies of some new indole-3-propionamide derivatives (2001) Farmaco, 56 (11), pp. 835-840.

 Göker, H., Tunçbilek, M., Süzen, S., Kus, C., Altanlar, N. Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives (2001) Archiv der Pharmazie, 334 (5), pp. 148-152.

 Kendi, E., Ates-Alagoz, Z., Suzen, S., Buyukbingol, E. Crystal structure of 2-[(5′,6′,7′,8′-tetrahydro-5′,5′ ,8′,8′-tetramethyl)-2′-naphthyl] -1-ethyl-1H-benzimidazole-5-carboxylic acid ethyl ester (2001) Analytical Sciences, 17 (4), pp. 567-568.

 Göker, H., Süzen, S., Kuş, C., Boykin, D.W. Synthesis of new 2-aryl-4H-4-oxo-1-benzopyran oxime ethers (2000) Heterocyclic Communications, 6 (5), pp. 385-390.

 Süzen, S., Williams, J.M. Investigation of the synthesis of some dehydroalanine derivatives (2000) Turkish Journal of Chemistry, 24 (4), pp. 361-370.

 Suzen, S., Buyukbingol, E. Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines (2000) Farmaco, 55 (4), pp. 246-248.

 Ates-Alagoz, Z., Suzen, S., Buyukbingol, E., Caira, M.R. Synthesis and structure of 2-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalene)]-5-benzimidazole ethylcarboxylate monohydrate (2000) Journal of Chemical Crystallography, 30 (2), pp. 103-107.

 Suzen, S., Williams, M. Behaviour of dehydroalanine derivatives under hydrazinolysis conditions. Possible relevance to glycoprotein hydrazinolysis (1999) Journal of Peptide Science, 5 (6), pp. 283-286.

 Suzen, S., Buyukbingol, E. Evaluation of anti-HIV activity of 5-(2-phenyl-3'-indolal)-2 thiohydantoin (1998) Farmaco, 53 (7), pp. 525-527.

 Evcimen, N.D., Pekiner, B., Süzen, S., Büyükbingöl, E. The inhibitory effect of benzodiazepine derivatives on the bovine lens aldose reductase enzyme (1998) Biochemistry and Molecular Biology International, 45 (2), pp. 381-387.

 Ates, Z., Suzen, S., Buyukbingol, E. Effects of a benzimidazole compound on monooxygenase activities (1997) Farmaco, 52 (11), pp. 703-706.

 Buyukbingol, E., Suzen, S., Klopman, G. Studies on the synthesis and structure-activity relationships of 5-(3'- indolal)-2-thiohydantoin derivatives as aldose reductase enzyme inhibitors (1994) Farmaco, 49 (6), pp. 443-447.

 Publications with other international indexed journals

 Yılmaz, A.D., Karaaslan, C., Shirinzadeh, H., Suzen, S., Ozcan, S., Gurer Orhan, H. New Antioxidant Drug Development Studies on Neurohormone Melatonin and Synthetic Analogues. (2014) Academic Journal of Science. 3(2), 51-56. (Index Copernicus)

 Karaaslan, C., Suzen S. Electrochemical Behavior of Biologically Important Indole Derivatives, (2011) J Int. Electrochemistry, 2011, 1-10 (Expanded Academic Index, Chemical Abstracts Service (CAS), Directory of Open Access Journals (DOAJ))

 Conference Proceedings

Sezer, O., Ince, E., Ozturk-Ceylan, O., Akdermir, A., Suzen, S., Gurer-Orhan H. Design, synthesis and investigation of dual benefits of 2-methyl indole derivatives in hormone-dependent breast cancer: Aromatase inhibitory and antioxidant activity (2016) Toxicology Letters 258:S126

Suzen, S., Shirinzadeh, H., Karaaslan, C., Gurer-Orhan, H., Eren, B. Synthesis and in vitro antioxidant activity studies of melatonin analogue compounds. (2016) Toxicology Letters 258:S202.

 Suzen, S., Yilmaz, A.D., Karaaslan, C., Shirinzadeh, H., Coban, T. Indole-based melatonin analogue compounds as cellular ROS inhibitors: Investigation on the peroxidation of human erythrocyte membranes and oxidative hemolysis (2016) Toxicology Letters 258:S202-S203

 Yılmaz, A.D., Karaaslan, C., Shirinzadeh, H., Suzen, S., Ozcan, S., Gurer Orhan, H. New Antioxidant Drug Development Studies on Neurohormone Melatonin and Synthetic Analogues. (2014) Acad J Sci. 3(2), 51-56. (Index Copernicus)

 Ozcan, S., Uslu, D., Karaaslan, C., Shrınzadeh, H., Suzen, S., Gurer-Orhan, H. Comparision of antioxidant activities of newly synthesized melatonin analogues. (2013) Toxicology Letters 221S, S59–S256 .

 Yılmaz, A.D., Shirinzadeh, H., Coban, T., Suzen, S., Ozden, S. Synthesis and antioxidant activity evaluations of melatonin based analogue indole-hydrazide/hydrazone derivatives. (2012) BMC Proceedings 6(Suppl 4):P28. doi:10.1186/1753-6561-6-S4-P28

 Shirinzadeh, H., Yılmaz, AD., Yücel, N., Altanlar, N., Suzen, S., Ozden, S. Antimicrobial activity of indole-based melatonin analogues .(2012) BMC Proceedings  6(Suppl 4):P27. doi:10.1186/1753-6561-6-S4-P27

 Ozturk, D., Suzen, S., Sabuncuoglu, B., Akkus, B. Radioprotection of the Rat Kidney with a New Indole Based Compound. (2005) Int J Rad Oncol Biol Phys 63(2) Suppl 1, S437. DOI: http://dx.doi.org/10.1016/j.ijrobp.2005.07.746

Publications in National Journals

 Das-Evcımen N, Sarıkaya M, Karaaslan C, Yılmaz Ad, Shırınzadeh H, Suzen S. Rat Lung Aldose Reductase Inhibition Capacity of Substituted Indole Hydrazide/Hydrazone Derivatives. FABAD J.Pharm. Sci., 37(4), 169-174, 2012

 Karaaslan C., Suzen, S. Mucize Hormon Melatonin Hakkında Bilinmesi Gerekenler. (2012) Modern Fitofarmakoterapi ve Doğal Farmasötikler, 1, 30-36

 Ozturk D, Sabuncuoglu B, Suzen S, Akkus-Yıldırım B. İndol türevi yeni bir bileşik ile sıçanlarda radyasyon nefropatisinin engellenmesi (The prevention of radiation nephropaty in the rat with a new ındol based compound) (2004) Cumhuriyet Üniv. Tıp Fak. Dergisi., 26(3), 107-112.

 Ateş Alagöz, Z., Süzen, S. Oxidative damage in the central nervous system and protection by melatoni̇n [Santral si̇ni̇r si̇stemi̇ni̇n oksi̇dati̇f hasari ve melatoni̇n tarafindan korunmasi] (2001) Ankara Universitesi Eczacilik Fakultesi Dergisi, 30 (3), pp. 47-62.

 Ates-Alagoz Z, Suzen S. Structure-activity relationships of melatonin analogues. (2001)  Ankara Universitesi Eczacilik Fakultesi Dergisi., 30 (4), 41-52.

 Süzen, S. Investigations on the effect of base and solvents on the elimination of p-toluene sulphonyl group in the synthesis of dehydroalanine (2001) Ankara Universitesi Eczacilik Fakultesi Dergisi, 30 (1), 17-25.

 Suzen, S., Alagoz, Z., Puskullu, M.O. Antioxidant activities of indole and benzimidazole derivatives (2000) Fabad Journal of Pharmaceutical Sciences, 25 (3), 113-119.

 Suzen, S. The characterisation of the carbohydrate moieties of glycoproteins and the role of hydrazinolysis (1999) Fabad Journal of Pharmaceutical Sciences, 24 (4), 233-239.

 Suzen, S. The role of dehydroalanines in enzyme and peptide chemistry (1999) Ankara Universitesi Eczacilik Fakultesi Dergisi, 28 (2), 129-141.

 Suzen, S. Radioprotective agents in the treatment of cancer and the role of amifostine (1999) Ankara Universitesi Eczacilik Fakultesi Dergisi, 28 (2), 117-128.