ÖzGEÇMİŞ
Adı Soyadı : Özlem TEMİZ-ARPACI
Doğum Yeri : Ankara
Adres :
Ankara Üniversitesi Eczacılık Fakültesi
Farmasötik Kimya Anabilim Dalı 06100, Tandoğan / Ankara - Türkiye
Telefon : + (90) 312 2033076
E-mail : temiz@pharmacy.ankara.edu.tr
1.
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Lisans
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Eczacılık
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Ankara
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1985-1989
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Y. Lisans
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Farmasötik kimya
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Ankara
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1989-1991
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Doktora
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Farmasötik kimya
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Ankara
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1992-1998
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2.
Akademik Unvanlar:
Yardımcı Doçentlik Tarihi : 2001-2003
Doçentlik Tarihi : 2003-2009
Profesörlük Tarihi : 2009-.
3.
Yönetilen Yüksek Lisans ve Doktora
Tezleri
3.1.
Yüksek Lisans Tezleri
1.Mustafa
Arısoy: “Yeni 2-(p-sübstitüebenzil)-5-(2-sübstitüeasetamido) benzoksazol
türevlerinin sentezi, yapılarının aydınlatılması, mikrobiyolojik etkileri ve
kantitatif yapı-etki ilişkileri çalışmaları” 2005-2007.
2..Burcu Eylem Çiftçioğlu: “Bazı Yeni Sübstitüebenzazol Türevlerinin
Sentezi, Yapı aydınlatması ve Mikrobiyolojik Aktivite Çalışmaları” Başlama tarihi: 2008-2011.
3. Refiye Tekiner “ Sistemik Fungus
Enfeksiyonlarında Kullanılan Antifungaller ve Biyoyararlanım Çalışmaları” 2009-2011
3.2.
Doktora Tezleri
Mustafa Arısoy: “Bazı Yeni
Heterosiklik Bileşiklerin Sentez, Yapı Aydınlatmaları, Antimikrobial
Etki, Çalışmaları”2007-.
4.
Yayınlar
4.1.
Uluslararası hakemli dergilerde
yayınlanan makaleler (SCI & SSCI & Arts and Humanities)
1. Şener, E., Yalçın, İ., Temiz,
Ö., Ören, İ., Akın,A.,Uçartürk, N.; “Synthesis and
Structure-Activity Relationships of Some 2,5-disubstituted Benzoxazoles and
Benzimidazoles as Antimicrobial Agents” Il
Farmaco, 52(2): 99-103
(1997).
2. Yalçın, İ., Kaymakçıoğlu,
B.K., Ören, İ., Şener, E., Temiz, Ö.,
Akın,A., Altanlar, N.; “Synthesis
and Microbiological Activity of
Some Novel N-(2-Hydroxyl-5- substituted
phenyl)benzacetamides, phenoxyacetamides
Thiophenoxyacetamides as the possible
metabolites of antimicrobial active Benzoxazoles” Il Farmaco, 52(11) 685-689 (1997).
3. Ören, İ., Temiz,
Ö., Yalçın, İ., Şener, E., Akın,A., Uçartürk, N.; “Synthesis and
Microbiological Activity of 5 (or 6)-methyl-2-substituted Benzoxazole and
Benzimidazole Derivatives” Arzneimittel-Forschung
/ Drug Research, 47(12): 1393-1397 (1997).
4. Temiz, Ö., Ören,
İ., Yalçın, İ., Şener, E., Uçartürk, N.;
“Synthesis and microbiological activity of some novel 5- or
6-methyl-2-(2,4-disubstitutedphenyl)benzoxazole derivatives” Il Farmaco, 53, 337-341 (1998).
5. Ören, İ., Temiz, Ö., Yalçın, İ., Şener, E.,
Altanlar, N.; “Synthesis and antimicrobial activity of some novel 2,5-
and/or 6-substituted benzoxazole and benzimidazole derivatives” European Journal of Pharmaceutical Sciences, 7, 153-160 (1998).
6. Akı-Şener, E., Temiz-Arpacı, Ö., Yalçın, İ., Altanlar,
N.; “Synthesis and microbiological activity of some novel 5-benzamido-
and 5-phenylacetamido- substituted 2-phenylbenzoxazole derivatives” Il Farmaco, 55, 397-405 (2000) .
7. Yalçın, İ., Ören, İ., Temiz, Ö., Akı-Şener, E.; “QSARs of some
novel isosteric heterocyclics with antifungal activity” Acta Biochimica
Polonica, 47 (2), 481-486
(2000).
8. Akı-Şener, E., Bingöl, K.K., Ören,
İ., Temiz-Arpacı, Ö., Yalçın, İ.,
Altanlar, N.: Synthesis and
microbiological activity of some
N-(o-hydroxyphenylbenzmides and phenylacetamides as the possible metabolites of
antimicrobial active benzoxazoles, Part II., Il Farmaco, 55,
469-476 (2000).
9. Temiz-Arpacı,
Ö., Ören, İ., Altanlar, N.;
“Synthesis and Antimicrobial Activity of Some Novel
2-(p-Substituted-phenyl)-5-Substituted-Carbonylaminobenzoxazoles”, Il Farmaco,57, 175-181
(2002).
10. Ünver, H., Temiz-Arpacı, Ö.,
Zengin D. M., Durlu T. N., “Crystal
structure, spectroscopic studies and
conformational analyses of 5-chloro-6-nitro-2-cyclohexylmethylbenzoxazole”, J. of Mol. Structure, 609, 205-212 (2002) .
11. Akı-Şener, E., Bingöl, K.K., Temiz-Arpacı,
Ö., Yalçın, İ., Altanlar, N, “Synthesis and microbiological activity
of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and
furamides as the possible metabolites of antimicrobial active benzoxazoles”, Il Farmaco,57, 451-456 (2002).
12. Temiz-Arpacı, Ö.,
Akı-Şener, E., Yalçın, İ., Altanlar, N., “Synthesis and antimicrobial
activity of some 2-[p-substituted-phenyl]benzoxazole-5-yl-arylcarboxyamides”, Arch. Der Pharm., 6, 283-288, (2002).
13. Temiz-Arpacı, Ö, Akı-Şener, E., Yalçın, İ.,
Altanlar, N., “Synthesis
and
microbiological activity of some novel N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl
carboxamide, -cyclohexyl acetamide and –cyclohexyl propionamide derivatives”, Il Farmaco, 57, 771-775, (2002).
14. Alper,
S., Temiz-Arpacı, Ö., Şener, E., Yalçın, İ., “Some bi- and ter- benzimidazole derivatives
as Topoisomerase I inhibitors”, Il Farmaco, 58, 497-507 (2003).
15. Akbay, A., Ören, İ., Temiz-Arpacı,
Ö., Akı-Şener, E., Yalçın, İ., “Synthesis and HIV-1 Reverse
Transcriptase Inhibitor activity of some 2,5,6-substituted benzoxazole,
benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives”, Arzneim. Forsch.,53(4), 266-271, (2003).
16.Yalçın, İ., Tekiner, B.,
Yıldız-Ören, İ., Temiz-Arpacı, Ö.,
Akı-Şener, E., Altanlar, N.;
“Synthesis and antimicrobial activity of some novel
2,6,7-trisubstituted-2H-3,4-dihydro-1,4-benzoxazin-3-one derivatives” Indian
Journal of Chemistry, Vol. 42B: 905-909 (2003).
17. Yıldız-Ören, İ., Tekiner,
B., Temiz-Arpacı,
Ö., Yalçın, İ., Akı-Şener, E., “3D-QSAR CoMFA studies on
2-(p-substitutedbenzyl)-5-(substitutedcarbonylamino)benzoxazoles as
antibacterial agents against Staphylococcus aureus” Asian Journal of Chemistry,
Vol 16, Nos. 3-4, 1359-1366 (2004).
18. Yıldız-Ören, İ., Tekiner, B., Yalçın, İ., Temiz-Arpacı, Ö., Akı-Şener, E.,
Altanlar, N.; “Synthesis and
antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles”
Archiv der Pharmazie , 337(7), 402-410, 2004.
19. Yıldız-Ören, İ., Akı-Şener,
E., Ertaş, C., Temiz-Arpacı, Ö.,
Yalçın, İ., Altanlar, N.; “Synthesis and microbiological activity of some
substituted N-(2-hydroxy-4-nitrophenyl)benzamides and phenylacetamides as the
possible metabolites of antimicrobial active benzoxazoles” Turkish Journal of
Chemistry , 28, 441-449, 2004.
20. Pınar, A., Yurdakul, P.,
Yıldız-Ören, İ., Temiz-Arpacı, Ö., Acan,
N.L., Akı-Şener, E., Yalçın, İ.; “ Some fused
heterocyclic compounds as eukaryotic topoisomerase II inhibitors”, Biochemical and
Biophysical Research Communications, Volume 317, Issue 2, 30 April 2004, Pages
670-674.
21. Plember, R.K., Erlandenson, K.J.,
Lakdawala, A.S., Sun, A., Prussia, A., Boonsombat, J., Akı- Şener, E., Yalçın, İ., Yıldız, İ., Temiz-Arpacı,
Ö., Tekiner, B., Liotta, D., Synder, J.P., Compans, R.W.; "A Novel Target
Site for Template-Based Design of Measles Virus Entry Inhibitors" PNAS (Proceedings of the National Academy of
Sciences of the United States of
America), 101(15), 5628- 5633, 2004.
22. Temiz-Arpacı, Ö., Özdemir, A., Yalçın, İ., Yıldız, İ.,
Akı-Şener, E., Altanlar, N.,
“Synthesis and antimicrobial
activity of some5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-
substitutedpiperazin-1-yl)acetamido]-2-(p-substitutedphenyl)benzoxazoles”
Archiv der Pharmazie, 338 (2-3),
105-111, 2005.
23. Temiz-Arpacı, Ö., Tekiner-Gülbaş, B., Yıldız, İ.,
Akı-Şener, E., Yalçın, İ., “ 3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase
II inhibitors by using comparative molecular field analysis method” Biorg.&
Med. Chem., 1;13(23) 6354-9 (2005)
24. Varga, A., Akı-Şener, E., Yalçın,
I., Temiz-Arpacı, Ö.,
Tekiner-Gülbaş, B.,Cherepnev G., Molnar, J. “ Induction of
apoptosis and necrosis by resistance benzazoles and benzoxazines on tumour cell
line mouse lymphoma L5718 Mdr+cells, In Vivo, 19(6) 1087-91 ( 2005).
25. Ozlem Temiz-Arpaci, Tulay Coban, Betul Tekiner-Gulbas,
Benay Can-Eke, Ilkay Yildiz, Esin Aki-Sener, Ismail Yalcin and Mumtaz
Iscan, A study on the antioxidant activities of
some new benzazole derivatives, Acta
biologica hungarica, 57(2) 201-209 (2006).
26. Tekiner-Gülbaş, B., Temiz-Arpacı, Ö., Yıldız, İ.,
Akı-Şener, E., Yalçın, İ., “3-D QSAR study on heterocyclic topoisomerase II inhibitors using
CoMSIA” SAR and QSAR 17(2), 121-132 (2006).
27. S. Alper-Hayta, E. Akı-Sener, B.
Tekiner-Gulbas, I. Yıldız, O.
Temiz-Arpacı, I. Yalcın and N. Altanlar, “Synthesis, antimicrobial activity and QSARs
of new benzoxazine-3-ones” European Journal of Medicinal Chemistry,
41(12):1398-404 (2006).
28. P.L. Anto, C. Yohannan
Panicker, Hema Tresa Varghese, Daizy Philip, Ozlem Temiz-Arpaci, Betul Tekiner-Gulbas and Ilkay Yildiz, “Vibrational spectroscopic studies and AB
initio calculations of 5-methyl-2-(p-fluorophenyl)benzoxazole”, Spectrochimica Acta Part A: Molecular and Biomolecular
Spectroscopy, 67, 744-749 (2007).
29.TEKINER-GULBAS, B.,
TEMIZ-ARPACI, O., OKSUZOGLU,
E., EROGLU, H., YILDIZ, I., DIRIL, N., AKI-SENER, E.,
YALCIN, I., "QSAR of Genotoxic Active Benzazoles", SAR and QSAR in
Environmental Research, 18, 251–263, (2007).
30.TEKINER-GULBAS, B., TEMIZ-ARPACI, O., YILDIZ, O., ALTANLAR, N., "Synthesis and In
Vitro Antimicrobial Activity of New 2-[p-Substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles",
European Journal of Medicinal Chemistry, 42(10):1293-9 (2007)
31.ERTAN, T., YILDIZ,
I., OZKAN, S., TEMIZ-ARPACI, O.,
KAYNAK, F., YALCIN, I., AKI-SENER, E., ABBASOGLU, U., "Synthesis and
Biological Evaluation of New n-(2-Hydroxy-4(or 5)-nitro/ aminophenyl)benzamides
and Phenylacetamides as Antimicrobial Agents", Bioorganic and Medicinal
Chemistry, 15, 2032-2044, (2007).
32. OKSUZOGLU, E., TEMIZ-ARPACI, O., TEKINER-GULBAS, B.,
EROGLU, H., SEN, G., ALPER, S., YILDIZ, I., DIRIL, N., AKI-SENER, E., YALCIN,
I., “ A study on the genotoxic activities of some new benzoxazoles”, Med. Chem.
Res., 16(1), 1-14, (2007).
33. YILDIZ, I., ERTAN,
T., BOLELLI, K., TEMIZ-ARPACI, O., YALCIN, I., AKI, E., “QSAR and pharmacophore
analysis on amides against drug-resistant S.
aureus”, SAR and QSAR in Environmental Research, 19, 101–113, (2008).
34. AMBUJAKSHAN, KR., MADHAVAN, V.S., VARGHESE, H.T., PANICKER,
C.Y., TEMİZ-ARPACI, O.,
TEKINER-GULBAS, B., YILDIZ, I., “Vibrational spectroscopic studies and ab
initio calculations of 5-methyl-2-(p-methylaminophenyl)benzoxazole” Spectrochim Acta A Mol Biomol Spectrosc.,
69(3), 782-788, (2008).
35. OKSUZOGLU, E.,
TEKINER-GULBAS, B., ALPER, S., TEMIZ-ARPACI,
O., ERTAN, T., YILDIZ, I., DIRIL, N., SENER-AKI, E., YALCIN, I., "Some
Benzoxazoles and Benzimidazoles as DNA Topoisomerase I and II Inhibitors",
Journal of Enzyme Inhibition and Medicinal Chemistry, 23(1), 37-42, (2008).
36. TEMİZ-ARPACI, O.,
YILDIZ, I., OZKAN, S., KAYNAK, F., AKI-SENER, E., YALCIN, I., “Synthesis and
biological activity of some new benzoxazoles”, Eur J Med Chem., 43(7) 1423-1431,
(2008).
37. ARISOY, M., TEMIZ-ARPACI,
O., YILDIZ, I., KAYNAK-ONURDAG, F., AKI, E., YALCIN, I., ABBASOGLU, U.,
“Synthesis, antimicrobial activity and QSAR studies of
2,5-disubstitutedbenzoxazoles”, SAR
and QSAR in Environmental Research, 19(5-6), 589-612 (2008).
38.
ALPER-HAYTA, S., ARISOY, M., TEMIZ-ARPACI,
O., YILDIZ, I., AKI, E., ÖZKAN, S., KAYNAK, F., "Synthesis,
Antimicrobial Activity, Pharmacophore Analysis of Some New
2-(Substitutedphenyl/ benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles", European
Journal of Medicinal Chemistry, 43(11), 2568-2578 (2008).
39. MARY, YS., VARGHESE, H.T., PANICKER, Y.C., ERTAN, T., YILDIZ,
I., TEMIZ-ARPACI, O., “Vibrational
spectroscopic studies and ab initio calculations of
5-nitro-2-(p-fluorophenyl)benzoxazole”
Spectrochim Acta A Mol Biomol Spectrosc., 71(2), 566-571 (2008).
40. ERTAN, T., YILDIZ, I., TEKINER-GULBAS, B., BOLELLI, K., TEMIZ-ARPACI, O., OZKAN, S., KAYNAK,
F., YALCIN, I., AKI, E., “Synthesis, biological evaluation and 2D-QSAR analysis
of benzoxazoles as antimicrobial agents.” Eur J Med Chem.44(2), 501-510 (2009).
41. PANICKER, C.Y., VARGESE, H.T., RAJI, A., RAJU, K.,
ERTAN-BOLELLI, T., TEMIZ-ARPACI, O.,
YILDIZ, I., NOGUERA, H.I.S.” IR Raman and SERS spectra of
2-phenoxymethylbenzothiazole” Spectrochim Acta A Mol Biomol Spectrosc., 74(1),
132-139 (2009).
42. MARY, Y.S., RAJU, K., YILDIZ, I., TEMIZ-ARPACI, O., NOGUERA, H.I.S., GRANADEIRO, C.M., ALSENOY, C. “FT-IR, FT-Raman, SERS and computational
study of 5-ethylsulphonyl-2-(o-chlorobenzyl)benzoxazole” Spectro. Acta Part A:
Mol. And Biomol. Spec. 96, (2012), 1386-1425.
43. ARISOY,
M., TEMIZ-ARPACI, O., KAYNAK-ONURDAG,
F., OZGEN, S. “Synthesis and
Antimicrobial Activity of Novel Benzoxazoles”, Z. Naturforsch. 67C, 9-10, 466-472 (2012).
44. TEMIZ-ARPACI,
O., CIFCIOGLU-GOZTEPE, B.E., KAYNAK-ONURDAG, F., OZGEN, S., SENOL, F.S., ERDOGAN-ORHAN, I. “Synthesis
and Different Biological Activities of Novel Benzoxazoles” Acta Biologica
Hungarica 64 (2), 2013.
4.2. Yurt İçi
Hakemli Dergilerdeki Özgün-Derleme Yayınları
1. Şener, E., Temiz, Ö.,
Ören, İ., Yalçın, İ., Akın, A., Uçartürk, N.; “Synthesis, Antibacterial
Activity and QSAR’s of some 5-Substituted-2-(p-Substitutedbenzyl)benzoxazoles
using the Free-Wilson Analysis” Ankara
Üniversitesi Eczacılık Fakültesi Dergisi, 24 (1):
10-20 (1995).
2.Temiz, Ö.;
“ QSARs of some 5- or 6-methyl-2-substituted benzoxazoles against Candida albicans”, Turkish Journal of Medical Science, 31, 493-497 (2001).
3.Ören, İ., Temiz-Arpacı, Ö., Yalçın, İ., Akı-Şener; “QSARs of
some novel benzoxazole, benzimidazole and oxazolo(4,5-b)pyridine derivatives
against C. albicans”, Ankara Üniversitesi Eczacılık Fakültesi
Dergisi 31/1, 21-32 ,(2002).
4. Temiz-Arpacı,
Ö., Ören, İ., Akı-Şener, E., Yalçın, İ., Tekiner, B.;
“QSARs of some antıbacterıal active
benzoxazoles Against B. subtilis”, Ankara Üniversitesi Eczacılık Fakültesi Dergisi31/2, 73-81 ,(2002).
5. TEMİZ-ARPACI,
Ö.,
KAYNAK-ONURDAG, F.” Antimikrobiyal etkili yeni bir benzoksazol bileşiği”, Ankara Üniversitesi Eczacılık Fakültesi
Dergisi 35/3, 189-196 ,(2006).
6. Temiz, Ö., Şener, E.; “Mikrobiyolojik Etkili
Benzoksazol, Benzimidazol, Benzotiyazol ve Oksazolo(4,5-b)Piridin Türevleri” Ankara Üniversitesi Eczacılık Fakültesi
Dergisi, 21 (1-2): 36-52 (1992).
7. Temiz,
Ö., Şener, E.; “Yeni Geliştirilen
Benzodiazepin Türevleri ve Biyolojik
Etkileri” Ankara Üniversitesi
Eczacılık Fakültesi Dergisi, 23 (1-2): 37-52 (1994).
5. ATIF H-İNDEKS : 15