PROF.DR. MERAL TUNÇBİLEK    
Name : MERAL
Surname : TUNÇBİLEK
E-Mail :
Phone Number : 203 30 71
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : Pharmaceutical Chemistry
Personal Information

MERAL TUNCBILEK, Ph. D. 
Ankara University, Faculty of Pharmacy, 
Department of Pharmaceutical Chemistry, 
Tandogan 06100, Ankara, Turkey 
Office : +90 (312) 203 3071 
Fax : +90 (312) 213 1081 
E-mail: tuncbile@pharmacy.ankara.edu.tr

 

DATE of BIRTH and PLACE : Jan 3, 1964, Siirt 
MARITAL STATUS :  Married, one children 
ACADEMIC QUALIFICATIONS: 
1985 :  
BS: University of Ankara, Fac. of Pharmacy 
1988 :  
Master Degree University of Ankara, Fac. of Pharmacy 
1994 :  
Ph.D.,  Pharmaceutical Chemistry, Ankara University, Fac. of Pharmacy 
1996:   
Assistant Professor, Pharmaceutical Chemistry, Ankara University, Fac. of Pharmacy 
1999:   
Associate Professor, Pharmaceutical Chemistry, Ankara University, Fac. of Pharmacy  
2001-2003:   
Visiting Professor, Department of Chemistry & Biochemistry, Auburn University, College of Sciences and Mathematics, AL, USA  
2006:   
Professor, Pharmaceutical Chemistry, Ankara University, Fac. of Pharmacy  

CURRENT STATUS: 
Faculty 

RESEARCH  INTEREST : 
Drug Synthesis, Purine, Nucleoside, Benzopyran,  Benzimidazoles, Dihydropyridine, Thiazolidindione, as heterocyclics. Anticancer, antiviral, antimicrobial, antioxidant, cardiovascular compounds. 
Drug analysis.

AWARDS:
1996: Mustafa Nevzat Pharmacy Award 
2009: Novartis Pharmaceutical and Medicinal Chemistry Drug Design and Development Research Awards-2nd Place  
2013: Sanovel "Pharm. Erol Toksöz Drug Research Awards"-1st Place  

PUBLICATIONS:
1.
  Ertan, R., Tuncbilek, M.Studies on the Quantitative Determination Methods of Ofloxacin one of Fluoroquinolone Derivatives, Hacettepe Universitesi Eczacilik Fakultesi Dergisi, 11(1), 37-46 (1991) (Turkish). 
2.  Bozdag, O., Ayhan-Kilcigil, G., Tuncbilek, M., Ertan, R., Studies on the Synthesis of Some Substituted Flavonyl Thiazolidinedione Derivatives-I,  Turkish Journal of Chemistry, 23, 163-169 (1999). 
3.  Kendi, E., Özbey, S., Tuncbilek M., Ertan, R., Fun, H.K., Yip, B.C., The structure of ethyl allyl 1,4-dihydro-2,6-dimethyl-4-(4-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-3,5-pyridine dicarboxylate, Journal of Chemical Crystallography, 24(11), 747-751 (1994). 
4.  Göker, H., Tuncbilek, M., Leoncini, G., Buzzi, E., Mazzei, M., Rolland, Y., Ertan, R., Synthesis and Inhibitory Activities on Platelet Aggregation of Some Flavonoid Analogues, Arzneim. Forsch./Drug Res., 45(I), 150-155 (1995). 
5.  Göker, H., Ayhan, G., Tuncbilek, M., Ertan, R., Leoncini, G., Garzoglio, R., Mazzei, M., Synthesis and Antiaggregator Activity of Some New Derivatives of 4H-1-benzopyran-4-one, Eur. J. Med. Chem., 30, 561-567  (1995). 
6.  Kendi, E., Özbey, S., Tuncbilek, M., Ertan, R., 2'-Methyl-3'-nitro-flavone, Cryst. Res. Technol., 31(5), 611-615 (1996). 
7.  Tuncbilek, M., Göker, H., Ertan, R., Eryigit, R., Kendi, E., Altanlar, N., Synthesis and Antimicrobial Activity of Some New Anilino Benzimidazoles, Arch. Pharm. Pharm. Med. Chem., 330, 372-376 (1997). 
8.  Göker, H., Tuncbilek, M.,  Ayhan, G., Altanlar, N., Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity, Il Farmaco, 53, 415-420 1998). 
9.  Kendi, E., Özbey, S., Tuncbilek, M., Göker, H., 1-Benzyl-2-(2,6-dichloroanilino-methyl)-1H-benzimidazole, Acta Cryst., C54, 854-856 (1998). 
10.  Özbey, S., Kendi, E., Göker, H., Tuncbilek, M., The structure of 1-(p-fluorophenylmethyl )-2-(4-methyl-1-piperazinyl)-1H-benzimidazole hydrogen fumarate, Journal of Chemical Crystallography, 28, 461-464 (1998). 
11.  Ayhan-Kilcigil, G., Bozdag, O., Tuncbilek, M., Altanlar, N., Ertan, R., Synthesis and antimicrobial activity of flavone-6-carboxaldehyde oxime ether derivatives, Pharmazie, 54, 228-229 (1999). 
12.  Bozdag, O., Tuncbilek, M., Ayhan-Kilcigil, G., Ertan, R., Studies on the synthesis of some substituted flavonyl thiazolidinedione derivatives, II, Pharmazie, 54, 151-152 (1999). 
13.  Tuncbilek, M.Ertan, R., Synthesis of some 4-(3' or 4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-1,4-dihydro-pyridine derivatives as potential calcium channel antagonists, Pharmazie, 54(4), 255-259 (1999). 
14.  Tuncbilek, M., Bozdag, O., Ayhan-Kilcigil, G., Altanlar, N., Büyükbingöl, E., Ertan, R.,  Synthesis and Antimicrobial Activity of Some New Flavonyl Oxime Ether Derivatives, Arzneim.-Forsch/ Drug Res., 49(II), 10, 853-857 (1999). 
15.  Gokay, O., Tuncbilek, M., Ertan, R., Penetration of the pulp chamber by carbamide peroxide bleaching agents on teeth restored with a composite resin, Journal of Oral Rehabilitation, 27, 428-431, 2000. 
16.  Tuncbilek, M., Altanlar, N., Synthesis and Antimicrobial Evaluation of Some 3-(Substituted  phenacyl)-5-(4'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene)-2,4-thiazolidinediones, Il Farmaco,54, 475-478 (1999). 
17.  Ayhan-Kilcigil, G., Tuncbilek, M., Altanlar, N., Göker, H., Synthesis and antimicrobial activity of some new benzimidazole carboxylates and carboxamides, Il Farmaco, 54, 562-565 (1999). 
18.  Tuncbilek, M., Özbey, S., Kendi, E., Yildirim, E., Erol, K., Ertan, R., Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-(4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-3,5-pyridine dicarboxylate, Il Farmaco, 54, 660-665 (1999). 
19.  Tunçbilek, M., Ayhan-Kilcigil, G., Ertan, R., Can-Eke, B., Iscan, M., Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver, Pharmazie, 55(5), 359-361, 2000. 
20.  Göker, H., Ayhan-Kilcigil, G., Tunçbilek, M., Kus, C.,  Ertan, R., Kendi, E., Özbey, S., Fort, M., Garcia, C., Farre, A.J., Synthesis and Antihistaminic H1 Activity of 1,2,5(6)-Trisubstituted Benzimidazoles, Heterocycles, 51(11), 2561-2573, (1999). 
21.  Gökay, O., Yilmaz, F., Akin, S., Tunçbilek, M., Ertan, R., Penetration of the Pulp Chamber by Bleaching Agents in Teeth Restored with Various Restorative Materials, Journal of Endodontics, 26(2), 92-94 (2000). 
22.Ozcan, S., Kendi, E., Tuncbilek, M., Goker, H., Methyl 1-(4-Chlorobenzyl)-2-(4-methylpiperazine-1-yl)-1H-benzimidazole-5-carboxylate hemihydrate, Acta Cryst., C56, 459-460 (2000).
23. Ayhan-Kilgicil, G., Tuncbilek, M., Ertan, R., Synthesis of a new dihydropyridine derivative containing a known vasodilator khellin, Turk. J. Chem., 24, 255-259 (2000).
24. Kruk, I., Kladna, A., Lichszteld, K., Michalska, T., Aboul-Enein, H.Y., Tuncbilek, M., Ertan, R., The Antioxidant Activity of 4-Flavonyl-1,4-Dihydropyridine Derivatives, Biopolymers & Biospectroscopy, accepted for publication, 2001. 
25. Goker,H., Tuncbilek, M., Süzen, S., Kus, C., Altanlar, N., Synthesis and Antimicrobial Activity of Some new 2-Phenyl-N-substituted carboxyamido-1H-benzimidazole derivatives, Arch. Pharm. Pharm. Med. Chem., submitted, 2001.    
26. Tuncbilek, M., Bozdað-Dündar, O., Ayhan-Kýlcýgil, G., Ceylan, M., Waheed, A., Verspohl, E.J., Ertan, R., Synthesis and hypoglycemic activity of somesubstituted flavonyl thiazolidine derivatives-fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones, Il Farmaco, 58, 79-83, 2003.     
27. Tuncbilek, M., Schneller, S.W., 9-Deaza-5'-noraristeromycin, Bioorganic Medicinal Chemistry, 11, 3331-3334, 2003.     
28.  Bozdað-Dündar, O., Tuncbilek, M., Altanlar, N., Ertan, R., Synthesis and Antimicrobial Activity of Flavone-3'-carboxaldehyde Oxime Ether Derivatives, Arzneim.-Forsch./Drug Res., 53(7), 522-525, 2003.    
29. Tuncbilek, M., Schneller, S.W., 5'-Nor carbocyclic ribavirin, Nucleosides, Nucleotides & Nucleic Acids, 22(11), 1995-2001, 2003.    
30. Tuncbilek, M., Can-Eke, B., Ayhan-Kilcigil, G., Çoban, T., Iscan, M., Evaluation of the Antioxidant Effect of Some Flavonylthiazolidinediones by Determining Their Effects on Lipid peroxidation, Superoxide Anion Formation, and 2,2-Diphenyl-1-picrylhydrazyl Stable Free Radical, Bioll. Pharm. Bull., 27(6), 912-915, 2004.     
31. Ayhan-Kilcigil, G., Çoban, T., Tuncbilek, M., Can-Eke, B., Bozdað-Dündar, O., Ertan, R., Iscan, M., Antioxidant Properties of Some Flavone-6(4)-carboxaldehyde Oxime Ether Derivatives, Arch. Pharm. Res., 27(6), 610-614, 2004.     
32. Tuncbilek, M., Altanlar, N., Synthesis of New 3-(Substituted Phenacyl)-5-[3'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones and their Antimicrobial Activity, Arch. Pharm. Chem. Life Sci., 339, 213-216, 2006.     
33.  Kaynak, F.B., Özbey, S., Tuncbilek, M., Alp, M., Synthesis and crystal structure of 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole, Struct. Chem., 19, 477-480, 2008.    
34.  Tuncbilek, M., Ates-Alagöz, Z., Altanlar, N., Karayel, A., Özbey, S., Synthesis and antimicrobial evaluation of some new substituted purine derivatives, Bioorganic & Medicinal Chemistry, 17, 1693-1700, 2009.     
35. Tuncbilek, M., Kiper, T., Altanlar, N., Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA, European Journal of Medicinal Chemistry, 44, 1024-1033, 2009.     
36. Kus, C., Ayhan-Kilcigil, G., Tuncbilek, M., Altanlar, N., Çoban, T., Can-Eke, B., Iscan, M., Synthesis, Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives, Letters in Drug & Discovery, 6, 374-379, 2009.     
37. Tuncbilek, M., Bilget Guven, E., Onder, T., Cetin Atalay, R., Synthesis of Novel 6-(4-substituted piperazine-1-yl)-9-(ß-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells, Journal of Medicinal Chemistry, 55, 3058-3065, 2012.

38. Demir Z., Bilget Guven E., Ozbey S., Kazak C., Cetin Atalay R., Tuncbilek, M., Synthesis of novel substituted purine derivatives and identification of the cell death mechanism. European Journal of Medicinal Chemistry, 89(7), 701-720, 2015.

39. Kucukdumlu A., Tuncbilek, M., Bilget Guven E., Cetin Atalay R., Synthesis of Some Substituted 6-Phenyl Purine Analogues and Their Biological Evaluation as Cytotoxic Agents, Acta Chim. Slov., 64, 621–632, 2017.

40. Meral Tuncbilek, Aslıgul Kucukdumlu, Ebru Bilget Guven, Duygu Altiparmak, Rengul Cetin-Atalay, Synthesis of novel 6-substituted amino-9-(b-D-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells, Bioorganic & Medicinal Chemistry Letters 28, 235–239, 2018.