PROF.DR. ZEYNEP ALAGÖZ    
Name : ZEYNEP
Surname : ALAGÖZ
E-Mail :
Phone Number : 0-312-203 3078
Title : PROF.DR.
Unit : FACULTY OF PHARMACY
Department : Department of Pharmaceutical Chemistry
Personal Information

biographical sketch

name                                                                                                         position title                                

 Zeynep Ates-Alagoz                                                                              Full Professor

eRA Commons User Name:  zalagoz

 

 

education /TRAINING

 

institution and location                                                                                  

degree                           

 year(s)

field of study

Univ. of Ankara, Faculty of Pharmacy, Turkey

B.S.

1995

Pharmacy

Univ. of Ankara, Faculty of Pharmacy, Turkey

M.S.

1998

Medicinal Chemistry

Univ. of Ankara, Faculty of Pharmacy, Turkey

Ph.D.

2003

Medicinal Chemistry

Univ. of Ankara, Faculty of Pharmacy, Turkey

Fellow

2003-06

Medicinal Chemistry

Univ. of the Sciences, Philadelphia,PA     

Fellow

2008-10

Medicinal Chemistry

 

 

A.  Personal Statement

 

 My research interests are in the area of drug discovery focusing on both organic synthesis and structure-activity relationships. I usually perform the organic synthesis work. We have synthesized novel compounds having indole/benzimidazole/thiazolidinedione ring systems and evaluated their antioxidant, antimicrobial, and anticancer activities. We have also conducted structure-activity studies of retinoidal and melatonergic compounds. Currently, I am working on several projects including syntheses of novel NMDA receptor antagonists for treatment of Alzheimer disease, and syntheses of novel radiosensitizers for anticancer activity. I have synthesized the compounds used in preliminary studies for this project. I will also synthesize the target compounds.

 

B.  Positions and Honors

 

Positions and Employment

 

1996-2006:               Graduate Research and Teaching Associate, Department of Pharmaceutical Chemistry, University of Ankara, Faculty of Pharmacy.

2006- 2012:              Associate Professor, Department of Pharmaceutical Chemistry, University of Ankara, Faculty of Pharmacy.

2008- 2010:              Postdoctoral Research Associate, Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania.

Jan.-June 2011:      Research Assistant professor, Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania.

2011-present:        Adjuct  Associate professor, Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania.

2012-present:        Full Professor, Department of Pharmaceutical Chemistry, University of Ankara, Faculty of Pharmacy.

 

Teaching

 

University of the Sciences, Philadelphia College of Pharmacy

Course Coordinator & Lecturer, Fundamentals of Pharmacology, PC305

Course Coordinator & Lecturer, Introduction to Pharmacology, PHA303

 

Current: Ankara University Faculty of Pharmacy

Pharmaceutical Chemistry IV, ECZ 250456

Organic Chemistry I, ECZ 250255

Organic Chemistry II, ECZ 250256

 

Near East  University Faculty of Pharmacy

Pharmaceutical Chemistry II, NEPHAR 314

 

Professional Activities

 

Reviewer: 

Journal: Archiv Der Pharmazie, Journal of Heterocyclic Chemistry, Tetrahedron Letters, Molecules, Turkish Journal of Chemistry

Book: Medicinal Chemistry & Drug design, Pearson Education

 

Member of Social Committee of International Symposium on Pharmaceutical Sciences-ISOPS-8 (2006-Ankara)


Member of Scientific Committee of International Symposium on Pharmaceutical Sciences-ISOPS-10 (2012-Ankara)


Member of Scientific Committee of International Symposium on Pharmaceutical Sciences-ISOPS-11 (2015-Ankara)



Member:  American Chemical Society (ACS), American Association of Pharmaceutical Sciences (AAPS), Turkish Phamaceutical and Medicinal Chemistry Association (Has held various positions in this organization), and Turkish Pharmacist’s Association.

 

Awards received:

2005-2006 Novartis, Pharmaceutics and Medicinal Chemistry Drug Design and Development Science award (Turkey) First Place

2009-2010 Novartis, Pharmaceutics and Medicinal Chemistry Drug Design and Development Science award (Turkey) Second Place

1995 Graduation from Univ. of Ankara, Faculty of Pharmacy, (Turkey) Second Place

 

C.  Selected Peer-reviewed Publications (in chronological order)

 

1.  Z. Ates, B. Can-Eke, S. Suzen, M. Iscan and E. Buyukbingol, "Effects of a Benzimidazole Compound on Monooxygenase Activities", Farmaco, 1997, 52, 703-706.

2.  Z. Ates-Alagoz, S. Suzen, E. Buyukbingol, M. R. Caira, “Synthesis and structure of 2-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalene)]-5-benzimidazole ethylcarboxylate monohydrate”, J. Chem. Crystallogr., 2000, 30, 103-107.

3.  E. Kendi, Z. Ates-Alagoz, S. Suzen, E. Buyukbingol, “Crystal Structure of 2-[(5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethyl)-2-naphthyl]-1-ethyl-1H-benzimidazole-5-carboxylic acid ethyl ester”, Analytical Sciences, 2001, 17, 567-568.

4.  Z. Ates-Alagoz, E. Buyukbingol, "Synthesis of Some New Tetrahydronapthalene Benzimidazole Derivatives", Heterocyclic Communications, 2001, 7, 455-461.

5.  S. Suzen, Z. Ates-Alagoz, B. T. Demircigil, S. Ozkan, “Synthesis and Analytical Evaluation by Voltammetric Studies of Some New Indole-3-propionamide Derivatives” , Farmaco, 2001, 56, 835-840.

6.  Z. Ates-Alagoz, B. Can-Eke, T. Coban, M. Iscan and E. Buyukbingol "Antioxidant Properties of Novel Benzimidazole Retinoids", Arch Pharm. (Weinheim), 2004, 337(4), 188-92.

7.  Z. Ates-Alagoz, Z. Buyukbingol, E. Buyukbingol, “Synthesis and Antioxidant Properties of Some Indole Ethylamine Derivatives as Melatonin Analogs”, Die Pharmazie, 2005, 60, 643-647.

8.  F. Balaban, Z. Ates-Alagoz, E. Buyukbingol, M. Iscan, "Genotoxicity Studies on Benzimidazole Retinoids", Die Pharmazie, 2005, 60, 861-868.

9.  Z. Ates-Alagoz, C. Kus, T. Coban, "Synthesis and antioxidant properties of some novel benzimidazoles containing substituted indole or 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene fragments", Journal of Enzym İnhibition and Medicinal Chemistry  2005, 20(4), 325-331.

10.  Z. Ates-Alagoz, T. Coban, S. Suzen, “A comperative study: Evaluation of antioxidant activity of melatonin and some indole derivatives” Medicinal Chemistry Research, 2005, 14(3), 169-179.

11.  Z. Ates-Alagoz, M. Alp, C. Kus, S. Yildiz, E. Buyukbingol, H. Goker, "Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles", Arch. Pharm. Chem. Life Sci. 2006, 339, 74-80.

12.  Z. Ates-Alagoz, S. Yildiz, E. Buyukbingol, “Antimicrobial Activities of Some Tetrahydronaphthalene-Benzimidazole Derivatives”, Chemotherapy, 2007, 53, 110-113.

13.  Z. Ates-Alagoz, T. Coban, E. Buyukbingol, “Synthesis and antioxidant activity of new tetrahydro-naphthalene-indole derivatives as Retinoid and Melatonoin Analogs”, Arch. Pharm. Chem. Life Sci., 2006, 339, 193-200.

14.  M. tuncbilek, Z. Ates-Alagoz, N. Altanlar, A. Karayel, S. Ozbey, “Synthesis and antimicrobial evaluation of some new substituted purine derivatives”, Biorganic and Medicinal Chemistry, 2009, 17, 1693-1700.

15.  A K. Piskin, Z. Ates-Alagoz, F. B. Atac, Y. Musdal and E. Buyukbingol, “DNA Binding and Antiproliferative Effects of Some Benzimidazole Retinoids”, Turkish Journal of Biochemistry, 2009, 34(1), 39-43.

16.  H. Goker, M. Alp, Z. Ates-Alagoz, S. Yildiz, “Synthesis and Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles”, J. Heterocyclic Chem., 2009, 46 (5), 936-948.

17.  Z. Ates-Alagoz,   N. Altanlar, E. Buyukbingol, “Synthesis and Antimicrobial Activity of New Tetrahydro-naphthalene-thiazolidinedione and thiohydantoine derivatives”, J. Heterocyclic Chem., 2009, 46 (6), 1375-1379.

18.  Z. Ates-Alagoz, S. Sun, J. Wallach, A. Adejare “Syntheses and Pharmacological Evaluations of Novel N-substitued bicyclo heptan-2-amines at NMDA receptors”, Chem. Biol. & Drug design, 78: 25-32: 2011.

19. Robert D. Bruno, Tadas S. Vasaitis, Lalji K. Gediya, Puranik Purushottamachar, Abhijit M. Godbole, Zeynep Ates-Alagoz, Angela M.H. Brodie, Vincent C.O. Njar “Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001) analogs: Head to head anti-tumor efficacy evaluation of VN/124-1(TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model”, Steroids, 76: 1268-1279: 2011.

20. Zeynep Ates-Alagoz, Natalia Coleman, Marlena Martin, Aaron Wan, Adeboye Adejare “In vitro Anticancer Properties of Novel Radiosensitizer Analogs” Chem. Biol. & Drug Design, 80: 853–861: 2012.

21. Zeynep Ates-Alagoz “Antioxidant Activities of Retinoidal Benzimidazole or Indole Derivatives in In Vıtro Model Systems” Current Medicinal Chemistry,  Special Issue "Chemistry and Biology of Antioxidants” in press 2013.

22. Vincent Njar, Puranik Purushottamachar, Abhijit M. Godbole, Lalji Gediya, Marlena Martin, Tadas Vasaitis, Andrew Kwegyir-Afful, Zeynep Ates-Alagoz “Systematic Structure Modifications of Multi-target Prostate Cancer Clinical Candidate Galeterone to Produce Novel Androgen Receptor Down-regulating Agents as an Approach to Treatment of Advanced Prostate Cancer" Journal of Medicinal Chemistry, in press, 2013.

23. Zeynep Ates-Alagoz, Adeboye Adejare “NMDA Receptor Antagonists for the Treatment of Depression” Pharmaceuticals, Special Issue “NMDA Receptor Antagonists for the Treatment of CNS Disorders” Pharmaceuticals 2013, 6(4), 480-499.

24. Natalia Coleman, Zeynep Ates-Alagoz, Boyenoh Gaye, Michelle Farbaniec, Shengguo Sun and Adeboye Adejare  “Toxicity studies on novel N-substituted bicyclo-heptan-2-amines at NMDA receptors” Pharmaceuticals, Special Issue “NMDA Receptor Antagonists for the Treatment of CNS Disorders” Pharmaceuticals 2013, 6(4), 536-545. 

25. Tuğba Somay Doğan, Mubeccel Durusoy, Zeynep Ates-Alagoz, Erdem Buyukbingol “Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid Derivatives”Turkish Journal of Biochemistry – Turkish Journal of Biochemistry, 2015; 40(6): 500–507.

26. Zeynep Ates-Alagoz “Antimicrobial Activities Of Benzimidazole-Based Molecules” Current Topics in Medicinal Chemistry,  Special Issue " New Developments in Medicinal Chemistry Highlighting Diverse Heterocyclic Ring Systems” 16, 2953-2962, 2016.

 

Patents:

1) A. Adejare, Z. Ates-Alagoz,  B. Gaye,“Bicyclo-heptan-2-amines Amines (Potent and selective σ2 receptor ligands)” US Patent  US8,735,590B2, 2014

2) A. Adejare, I. Mercier, Z. Ates-Alagoz, “Compounds And Compositions For Treatment Of Breast Cancer” US  2018 / 0280319 A1

 

Book Chapter:

1)      Zeynep Ates-Alagoz, Adeboye Adejare, "Prodrugs"  Remington: The Science and Practice of Pharmacy.  Pharmaceutical Press, Edited by Allen, Loyd V., Jr 22nd edition, September 15, 2012 0857110624 978-0857110626

2)      Zeynep Ates-Alagoz, Adeboye Adejare “Physicochemical Properties for Potential Alzheimer’s Disease Drugs: Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s disease, editör: Adeboye Adejare, Elseiver 2016.

 

Peer-reviewed National Publications:

 

1.  Z. Ates-Alagoz, S. Suzen, “Oxidative damage in the central nervous system and protection by melatonin”, J. Fac. Pharm. Ankara Univ., 2001, 30 (3), 47-62

2.  Z. Ates-Alagoz, S. Suzen, “Structure-Activity Relationships of Melatonin Analogues”, J. Fac. Pharm. Ankara Univ.,  2001, 30 (4), 41-52.

3.  S. Suzen, Z. Ates-Alagoz, M. O.  Puskullu, “Antioxidant Activities of Indole and Benzimidazole Derivatives”, FABAD J. Pharm. Sci., 2000, 25, 113-119.

4.  Z. Ates-Alagoz, “Structure-Activity Relationships of Some Melatonin Analogues that have antioxidant effect”, J. Fac. Pharm. Ankara Univ., 2005, 34 (2), 73-93

5. S. Atila, Z. Ates-Alagoz “Roles of NMDA Receptor Antagonists in Neuropathic Pain” J. Fac. Pharm. Ankara Univ.,39 (1) 51-68, 2010.

 

 

Books:

1.  "Pharmaceutical Chemistry Practices 1-2", 18 Authors, printed by Ankara University, ISBN 975-482-668-4, 2004

2.  "Pharmaceutical Chemistry Practices 3-4", 18 Authors, printed by Ankara University, ISBN 975-482-668-4, 2004

 

D.  Research Support

In general, our work deals with design, syntheses, and chemical characterizations of small organic molecules having antioxidant, antimicrobial and anticancer activities. Ongoing work in our laboratory focuses on design and syntheses of hypoxic cell radiosensitizers to improve their radiosensitizing abilities while decreasing their neurotoxicities.

 

1)       "Synthesis of retinoidal compounds and their effects on free radicals and lipid peroxidation" Ankara University Research Fund, 97-03-00-08,  1997-1999.

2)       “Retinodal Compounds and Their Effects on Cancer, DNA and Genotoxicity”

TÜBITAK,  98-03-00-03, 1998-2003.

3)       “Synthesis of new compounds against radiation and their biological evaluation”

 Ankara University Research Fund,, 98-03-00-03, 1998-2003.

4)       “Synthesis and Radioprotective Effects of Novel Melatonin Derivatives” Ankara University Research Fund,, 2001-08-03-029, 2001-2004.

5)        “Synthesis, antibacterial and antifungal activity studies of some novel heterocyclic compounds”, TÜBITAK, SBAG 3450, 2006-2008.

6)       “Non-Peptide Amyloid Plaque Formation Inhibitors”, Yardımcı Araştırmacı, 7R15NS36393-04 ,  National Institute of Neurological Disorders and Stroke, 2006-2010.

7)  “Synthesis, Structure Elucidation and Anticancer Activity of New indole-benzimidazole Derivatives” TÜBİTAK- SBAG-213S037- (2014-2016).

8)  “ Synthesis, Structure Elucidation and Antioxidant Activity of New pirole-benzimidazole Derivatives”  Ankara University Research Fund,-16H0237010-  - (2016-….). 



 

E. Presentations

 

1) ZEYNEP ATEŞ, BENAY CAN-EKE, SİBEL SÜZEN, MÜMTAZ İŞCAN ve ERDEM BÜYÜKBİNGÖL, "Effects of Newly Synthesized Benzimidazole Compound on Monooxygenase Activities", 5th International Symposıum on Pharmaceutical Sciences (ISOPS-5) Ankara University, Faculty of Pharmacy, ANKARA, 24-27 June 1997.

 

2) FULYA BALABAN, ZEYNEP ATEŞ-ALAGÖZ, SİBEL SÜZEN, ERDEM BÜYÜKBİNGÖL, MESUDE İŞCAN "Effects of Newly Synthesized Retinoid Derivatives on Human Lymphocyte Cultures” , 4th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries, Antalya, TURKEY, 12-16 April 2000.

 

3) ZEYNEP ATEŞ-ALAGOZ, ERDEM BÜYÜKBİNGÖL, "Synthesis of Some New Tetrahydro-Naphthalene-Benzimidazoles as Retinoid Analogues”, 6th International Symposium on Pharmaceutical Sciences (ISOPS-6) Ankara University, Faculty of Pharmacy, ANKARA, 27-29 June 2000.

 

4) YEŞİLADA, A., ASAL, B., BÜYÜKBİNGÖL, E., ATEŞ-ALAGOZ, Z., YILDIRIM, E., EROL, K. “ Synthesis and Investigation of the Antinociceptive and Anti-depressant Effects of The Stereoisomers of a Dipeptoid Analog of Cholecystokinin” , 6th International Symposium on Pharmaceutical Sciences (ISOPS-6) Ankara University, Faculty of Pharmacy, ANKARA, 27-29 June 2000.

 

5) SİBEL SÜZEN, ZEYNEP ATEŞ-ALAGÖZ, B. TOLGA DEMİRCİGİL, SİBEL ÖZKAN, “Synthesis and Analytical Evaluation by Voltammetric Studies of Some New Indole-3-propionic acid Derivatives”, 7th International Symposium on Pharmaceutical Sciences (ISOPS-7) Ankara University, Faculty of Pharmacy, ANKARA, 24-27 June 2003.

 

6) ZEYNEP ATEŞ-ALAGÖZ, TÜLAY ÇOBAN, SİBEL SÜZEN, “A comperative study: Evaluation of antioxidant activity of melatonin and some indole derivatives” 2nd International Meeting on Medicinal and Pharmaceutical Chemistry (IMMPC-2), ANTALYA, october 10-14, 2004.

 

7) ZEYNEP ATEŞ-ALAGÖZ, ZELİHA BÜYÜKBİNGÖL, ERDEM BÜYÜKBİNGÖL, "Synthesis some new indoles derivatives as melatonin analogues", 7th International Symposium on Pharmaceutical Sciences (ISOPS-7) Ankara University, Faculty of Pharmacy, ANKARA, 24-27 June 2003.

 

8) ZEYNEP ATEŞ-ALAGÖZ, SULHİYE YILDIZ, ERDEM BÜYÜKBİNGÖL, “Antimicrobial activities of some tetrahydronaphthalene-benzimidazole derivatives” World Conference on Magic Bullets Celebrating Paul Ehrlich’s 150th Birthday, Nürnberg, Germany, September 9-11, 2004.

 

9) ZEYNEP ATEŞ-ALAGÖZ, FULYA BALABAN, MESUDE İŞCAN, ERDEM BÜYÜKBİNGÖL, "Genotoxicity Studies on Tetrahydronaphthalene Benzimidazole Derivatives",  20th International Congress of Heterocyclic Chemistry, Palermo-ITALY, July 31-August5, 2005.

 

10) ERDEM BÜYÜKBİNGÖL, ZEYNEP ATEŞ-ALAGÖZ, KEVSER A.  PİŞKİN, “ DNA Binding and Antiproliferative Effect of 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-5-benzimidazole Derivatives” 20th International Congress of Heterocyclic Chemistry, Palermo-ITALY, July 31-August5, 2005.

 

11) CANAN KUŞ, ZEYNEP ATEŞ-ALAGÖZ, TÜLAY ÇOBAN, "Novel benzimidazoles containing substituted indole or 1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene fragments", 20th International Congress of Heterocyclic Chemistry, Palermo-ITALY, July 31-August5, 2005.

 

12) ZEYNEP ATEŞ-ALAGÖZ, TÜLAY ÇOBAN, Erdem BUYUKBINGOL, “Melatonoin-Retinoids as Potent Antioxidants”,  8th International Symposium on Pharmaceutical Sciences (ISOPS-8) Ankara University, Faculty of Pharmacy, ANKARA, 13-16 June 2006.

 

13) Zeynep ATES-ALAGOZ, Mehmet ALP, Canan KUS, Sulhiye YILDIZ, Erdem BUYUKBINGOL, Hakan GOKER, "Retinoidal Benzimidazoles as Potential Antimicrobial Agent", 4th Eurasian Meeting on Heterocyclic Chemistry, August 27-31, 2006 Thessaloniki, GREECE.

 

14) MERAL TUNÇBİLEK, Zeynep ATES-ALAGOZ, NURTEN ALTANLAR "Synthesis and Antimicrobial Activity of Novel 6-Amino Purine Derivatives”, 4th Eurasian Meeting on Heterocyclic Chemistry, August 27-31, 2006 Thessaloniki, GREECE.

 

15) Zeynep Alagoz, Shengguo Sun, and Adeboye Adejare “Discovery of a Novel NMDA Receptor Antagonist”, Cold Spring Harbor Laboratory Meetings & Courses Program, Neurodegenerative Diseases: Biology & Therapeutics December 4 - 7, 2008 Long island, NY, USA.

 

16) Zeynep Alagoz, Natalia Coleman, Shengguo Sun, and Adeboye Adejare, “Pharmaceutical Profiling of Novel NMDA Receptor Antagonist”, The Joseph B. Schwartz Memorial Symposium: Advances in Industrial Pharmacy, March 6, 2009, Philadelphia College of Pharmacy, The University of the Sciences, Philadelphia, USA.

 

17) Zeynep Alagoz, Natalia Coleman, Shengguo Sun, and Adeboye Adejare,   “Syntheses and Pharmacological Evaluation of Novel NMDA Receptor Antagonists” 238th ACS National Meeting & Exposition, August 16-20, 2009 Washington, DC, USA.

 

18) Hakan GOKER, Mehmet ALP, Zeynep ATES-ALAGOZ, Sulhiye YILDIZ, “Synthesis and Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles” Esoc 2009: 16 th European Symposium on Organic Chemistry, July 12-16, 2009, Prague, Czech Republic.

 

19) MERAL TUNCBILEK, Zeynep ATES-ALAGOZ, Nurten ALTANLAR, “Synthesis and Antimicrobial Evaluation of Some New Substituted Purine Derivatives”, 3rd European Conference on Chemistry for Life Sciences:Linking Chemistry with Biological Activity, September 2-5, 2009, Frankfurt, Germany

 

20) Boyenoh Gaye, Zeynep Alagoz, Adeboye Adejare, “Syntheses and Characterizations of Functionalized Single-Walled Carbon Nanotubes for Drug Delivery” 2009 AAPS Annual Meeting & Exposition, 8-12 November 2009, Los Angeles Convention center, Los Angeles, CA, USA.

 

21) Marlena Martin, Zeynep ATES-Alagoz, Natalia Coleman, Aaron WAN, Adeboye Adejare “In vitro Anticancer Properties of Novel Radiosensitizer Analogs”, Mid-atlantic Pharmacology Society 2009 Annual meeting, November 2, 2009, Philadelphia, PA, USA.

 

22) Zeynep ATES-Alagoz, MERAL TUNCBILEK, RENGUL ATALAY “Synthesis and Biological Activity of Some New Substituted Purine Derivatives in Human Cancer Cells” ACS Spring 2010 National Meeting & Exposition, March 21-25, 2010 San Francisco, California, USA.

 

23) Zeynep ATES-Alagoz, Natalia Coleman, Aaron WAN, Adeboye Adejare “In vitro Anticancer Properties of Novel Radiosensitizer Analogs”, ACS Spring 2010 National Meeting & Exposition, March 21-25, 2010 San Francisco, California, USA.

 

24) Marlena Martin, Zeynep ATES-Alagoz, Natalia Coleman, Aaron WAN, Adeboye Adejare “In vitro Anticancer Properties of Novel Radiosensitizers” University of the Sciences Annual Research Day, Thursday, April 8, 2010.

 

25) Boyenoh Gaye, Zeynep Alagoz, Adeboye Adejare, “Syntheses and Characterizations of Functionalized Single-Walled Carbon Nanotubes for Drug Delivery” University of the Sciences Annual Research Day, Thursday, April 8, 2010.

 

26) Carres Martinez, Natalia Coleman, Zeynep ATES-Alagoz, Adegoke Adeniji, Adeboye Adejare “Effects of novel NMDA receptors antagonists on mouse embryonic stem cell differentiation into neurons”  University of the Sciences Annual Research Day, Thursday, April 8, 2010.

 

27) A. SELEN GURKAN, Zeynep ATES-ALAGOZ, ERDEM BÜYÜKBİNGÖL, “Synthesis and Structural Elucidation of Some Novel Tetrahydronaphthalene Derivatives as Retinoid Analogues” 45th International Conference on Medicinal Chemistry: Drug discovery and Selection, July 1-3, 2009 Orleans, France.

 

28) ZEYNEP ATES-ALAGOZ, NATALIA COLEMAN, JASON WALLACH, ADEBOYE ADEJARE “Syntheses and Pharmacological Evaluations of Novel N-substitued bicycle heptan-2-amine Derivatives as NMDA Receptor Antagonists” 2010 FIP PSWC/AAPS Annual Meeting, November 14-18, 2010 New Orleans, LA, USA.

 

29) ZEYNEP ATES-ALAGOZ, NATALIA COLEMAN, AARON WAN, ADEBOYE ADEJARE “Design and Syntheses of Novel Radiosensitizer Analogs as Potent Anticancer Agents” 2010 FIP PSWC/AAPS Annual Meeting, November 14-18, 2010 New Orleans, LA, USA.

 

30)  CARRES GARNETT, POORNAPRIYA RAMAMURTHY, ZEYNEP ATES-ALAGOZ, ADEGOKE ADENIJI, KATE F. BARALD, ADEBOYE ADEJARE, NATALIA COLEMAN “Effects of Novel NMDA receptors antagonists on embryonic stem cell differentiation” 2010 FIP PSWC/AAPS Annual Meeting, November 14-18, 2010 New Orleans, LA, USA.

 

31) Boyenoh Gaye, Zeynep Alagoz, Adeboye Adejare,  “Conjugation of Doxorubicin to Single-walled Carbon Nanotube via a pH sensitive linker” 2010 FIP PSWC/AAPS Annual Meeting, November 14-18, 2010 New Orleans, LA, USA.

 

32) OLIVIA GRABOWSKI, BOYENOH GAYE, JASON WALLACH, ZEYNEP ATES-ALAGOZ “In Vitro cytotoxicity studies of Novel NMDA Receptor Antagonist” University of the Sciences Annual Research Day, Thursday, April 14, 2011.

 

33) ALYSSA KEIL, DOUGLAS FREDERICK, ZEYNEP ATES-ALAGOZ, RUY TCHAO, PETER J. HARVISON “Role of the Thiazolidinedione (TZD) Ring in the Mechanism of Toxicity of Structurally Similar Compounds” University of the Sciences Annual Research Day, Thursday, April 14, 2011.

 

34) CARRES C. MARTINEZ, BOYENOH GAYE, ZEYNEP ATES-ALAGOZ, ADEBOYE ADEJARE “In vitro evaluation of cytotoxicity of sigma-2 receptor ligands” University of the Sciences Annual Research Day, Thursday, April 14, 2011.

 

35) PURANİK PURUSHOTTAMACHAR,  ABHİJİT M. GODBOLE, LALJİ K. GEDİYA,., ZEYNEP ATES-ALAGOZ,  VİNCENT C.O. NJAR. Exploitation of multitarget prostate cancer clinical candidate VN/124-1 (TOK-001) to develop a novel class of androgen receptor down regulating agents for prostate cancer therapy. ACS Fall 2011 National Meeting & Exposition, August 28 – September 1, 2011 Denver, Colorado, USA.

 

36) Zeynep ATES-Alagoz,  Boyenoh Gaye, Adeboye Adejare “Syntheses and Anticonvulsant Activities of Novel NMDA Receptor Antagonists” 2011 AAPS Annual Meeting and Exposition, October 23-27, 2011Walter E. Washington Convention Center, Washington, D.C.

 

37) Zeynep ATES-Alagoz,  Boyenoh Gaye, Adeboye Adejare “Bicyclo-heptan-2-amines as Potent and selective σ2 receptor ligands” 2011 AAPS Annual Meeting and Exposition, October 23-27, 2011Walter E. Washington Convention Center, Washington, D.C.

 

38) Adeboye Adejare, Zeynep ATES-Alagoz, Shengguo Sun, JASON WALLACH "Novel NMDA Receptor Antagonists for Treatment of Neurodegenerative Disorders"  7th Annual International ITMAT Symposium, University of Pennsylvania, October 16 and 17, 2012.

 

39) Adeboye Adejare, Zeynep ATES-Alagoz, Shengguo Sun, JASON WALLACH "Novel NMDA Receptor Antagonists for Treatment of Neurodegenerative Disorders"  Cold Spring Harbor Laboratory Conference on Neurodegenerative Diseases, Cold Spring Harbor, NY, November 28 – December 1, 2012.

 

40) QUYNH NGUYEN, Boyenoh Gaye,  JASON WALLACH,  Zeynep ATES-Alagoz,  Adeboye Adejare “Antioxidant properties of novel NMDA receptor antagonists and radiosensitizers” University of the Sciences Annual Research Day, Thursday, April 12, 2012.

 

C41) Zeynep ATES-Alagoz,  Boyenoh Gaye, Adeboye Adejare “Bicyclo-heptan-2-amines as Potent and selective σ2 receptor ligands” 13th Belgian Organic Synthesis Symposium BOSS XIII, 15-20 Temmuz 2012, Leuven, Belçika.

 

42) Zeynep ATES-Alagoz, Boyenoh Gaye, Adeboye Adejare “Syntheses and Anticonvulsant Activities of Novel NMDA Receptor Antagonists” 10th International Symposium on Pharmaceutical Sciences (ISOPS-10) Ankara University, Faculty of Pharmacy, ANKARA, 26-29 June 2012.

 

43) ZEYNEP ATES-ALAGOZ,  ADEBOYE ADEJARE,  Syntheses and Anticonvulsant Activities of Novel N-Substituted bicyclo-heptan-2-amine derivatives as NMDA Receptor Antagonists, “RICT 2013 - Drug Discovery and Selection -When Chemical Biology Meets Drug Design”, July 03-05, Nice, France.

44) MUHAMMED A. ALAMRI, Zeynep Alagoz, Adeboye Adejare, “Bicyclo-heptane-2-amines as σ2 Receptor Ligands: Potential Use as Anticancer Agents” 2013 AAPS Annual Meeting & Exposition, 10-14 November 2013,Henry B. Conzales Convention center, San Antonio, USA.

45) ASHLEY RUSSELL, DIVYA SAVANT, ZEYNEP ATES-ALAGOZ, ADEBOYE ADEJARE, ISABELLA MERCIER “ Novel Arylsulfonyl Radiosensitizers for the Treatment of Triple Negative Breast Cancers” University of the Sciences Annual Research Day, Thursday, April 10, 2014.

46) ZEYNEP ATEŞ-ALAGÖZ,  FIKRIYE ZENGIN, MURAT YAMAN, OZLEN KONU “Synthesis and biological evaluation of novel indole-benzimidazole ethylsulfonyl derivatives as potential anticancer agents” 11th International Symposium on Pharmaceutical Sciences (ISOPS-11) Ankara University, Faculty of Pharmacy, ANKARA,  June 09-12, 2015.

47) FIKRIYE ZENGIN, ZEYNEP ATES-ALAGÖZ. ‘Synthesis, structure identification, and biological evaluation of novel indole-alkyl sulfonyl benzimidazoles’ 11th International Symposium on Pharmaceutical Sciences (ISOPS-11) Ankara University, Faculty of Pharmacy, ANKARA,  June 09-12, 2015.

48) CAGRİ ISİK, E. SILA ÖZDEMİR, OZLEN KONU, ZEYNEP ATES-ALAGOZ “Syntheses And Antıcancer Activity Of Novel Indole-Benzımıdazole Derıvatıves” 11th International Symposium on Pharmaceutical Sciences (ISOPS-11) Ankara University, Faculty of Pharmacy, ANKARA,  June 09-12, 2015.

49) ZEYNEP ATES-ALAGOZ, MURAT YAMAN, FIKRIYE ZENGIN, TUNA BAYDIN, OZLEN KONU “Screening Of Anticancer Activity And In Vivo Toxicity Of Novel Indolebenzimidazole Ethylsulfonyl Derivatives” The 9th European Zebrafish Meeting, Oslo, Norway, June 28-July 2, 2015.

50) FİKRİYE ZENGİN, MURAT YAMAN, OZLEN KONU, ZEYNEP ATES-ALAGOZ, “Design, Syntheses And Antıcancer Activity Of 5-(Alkylsulfonyl)-2-(5-subs-1H-indol-3-il)-1-subs-1H-Benzo[d]imidazoles” GPSS-1 st International Gazi Pharma Symposium Series, Antalya, 12-15 Kasım 2015.

51)   OZLEN KONU,  MURAT YAMAN,  FİKRİYE ZENGİN,  ZEYNEP ATES-ALAGOZ, “Identification of Novel Indole-benzimidazole Compounds with Antiproliferative and Ion Channel Modulatory Effects” 5th RSC / SCI symposium on Ion Channels as Therapeutic Targets, Cambridge, England,14th-15th March 2016.

52) GULBIN OZCELIKAY,  ZEYNEP ATES-ALAGOZ, SIBEL SUZEN, MAKSUT COSKUN, “A Study On The Contributions Of Faculty Of Pharmacy To Postgraduate Education With The-Job Training Program And Opinion Of Graduates On That Program” 22nd EAFP Annual Conference, Châtenay-Malabry, France, 12-14 May, 2016.

53) ZEYNEP ATES-ALAGOZ, GULBIN OZCELIKAY, “Ankara University Faculty Of Pharmacy Workshop Results Of Graduates” 22nd EAFP Annual Conference, Châtenay-Malabry, France, 12-14 May, 2016.

54)  54) Zengin, F., Yaman, M., Kisla, MM., Konu, O., Ates Alagoz, Z. “Synthesis, Structural Identification And Anticancer Effects Of Novel Phenothiazines For Hepatocellular Cancers” 12th International Symposium on Pharmaceutical Sciences (ISOPS-12) Ankara University, Faculty of Pharmacy, ANKARA,  June 26-29, 2018.

55)  55) Yaman, M., Tiryaki, RS., Zengin, F., Kisla, MM., Bayazeid, O., Keskus, AG., Ates Alagoz, Z., Konu O. “Molecular, Biochemıcal And In Silico Analyses Of Commercial And Novel Phenothiazines As Anticancer Agents” 12th International Symposium on Pharmaceutical Sciences (ISOPS-12) Ankara University, Faculty of Pharmacy, ANKARA,  June 26-29, 2018.

56)  56) Baran, S., Zengin, F., Ates Alagoz, Z. “Synthesis, Structural  Identification Of Novel Indol-Thiazolidinedione Derivatives” 12th International Symposium on Pharmaceutical Sciences (ISOPS-12) Ankara University, Faculty of Pharmacy, ANKARA,  June 26-29, 2018.

57)  57) Ates Alagoz, Z., Yildiz, S., Goker, H. “Syntheses And Antimicrobial Activities Of Novel Monocationic Indole-Benzimidazole Derivatives” 12th International Symposium on Pharmaceutical Sciences (ISOPS-12) Ankara University, Faculty of Pharmacy, ANKARA,  June 26-29, 2018.

58)  58) Murat Yaman, Fikriye Zengin, Zeynep Ates-Alagoz, Ozlen Konu “Effects of phenothiazines on zebrafish embryos xenotransplanted with GFP-expressing liver cancer cell lines, 2nd InternaƟonal FishMed Conference on Zebrafish Research, March 25-27 2018, IIMCB, Warsaw, Poland.

 

54)