RESEARCH ASSISTANT ZÜHAL KILIÇ KURT    
Name : ZÜHAL
Surname : KILIÇ KURT
E-Mail :
Phone Number : 203 30 86
Title : RESEARCH ASSISTANT
Unit : FACULTY OF PHARMACY
Department :
Personal Information

Zühal KILIÇ-KURT

Postdoctoral Research Assistant

Department of Pharmaceutical Chemistry,

Faculty of Pharmacy, Ankara University

Tandogan, 06100, Ankara, TURKEY.

zkurt@ankara.edu.tr

EDUCATION

09/2008 – 03/2014     Doctor of Philosophy

Ankara University (TURKEY), Faculty of Pharmacy, Department of Pharmaceutical Chemistry

Supervisor: Prof. Dr. Süreyya Ölgen

09/2005 – 06/2008      Master of Science

Ankara University (TURKEY), Faculty of Pharmacy, Department of Pharmaceutical Chemistry

Supervisor: Prof. Dr. Süreyya Ölgen

09/2001 – 06/2005     Bachelor of Science

Istanbul University (TURKEY), Faculty of Pharmacy

EMPLOYMENT

03/2014 – till now     Postdoctoral Research Assistant

Ankara University (TURKEY), Faculty of Pharmacy, Department of Pharmaceutical Chemistry.

03/2011 – 03/2014     Ph.D Candidate and Research Assistant

Ankara University (TURKEY), Faculty of Pharmacy, Department of Pharmaceutical Chemistry.

07/2006 – 01/2010     Pharmacist

Ankara University, School of Medicine, Ibn-iSina Hospital.

SKILLS

  • Synthesis and characterization of organic compounds on large and small scales by using modern synthesis techniques.
  • Purification of organic compounds by using extraction, coloumn chromatography, crystallization methods.
  • Skilled in interpretation of spectroscopic data (NMR, MS, IR, UV-VIS) for characterization of unknown compounds.
  • Hands on experience in FTIR and HPLC
  • Experience in molecular modeling such as molecular docking (Autodock vina).

PROJECTS

  • Synthesis of Pyrrolo[2,3-d]pyrimidines Designing as Multiple Receptor Tyrosine Kinase Inhibitors, Evaluation of Anticancer Potency and Structure-Activity Relationships, The Institute of Scientific and Technical Research of Turkey, 3001 - Starting R&D Projects Funding Program, 214S573, Research Manager, 01/2015-till now.
  •  Determination of Src kinase Enzyme Inhibitor Activity of Some Novel Indolin-2-one Compounds, BAP Project No: 13H3336002, Research Scientist, 2013-2014.
  • Synthesis and Characterization of Originally Designed Small molecule Inhibitors for Src Tyrosine Kinase and Establishing Kinase Profiling Compatible with Low Throughput Screening to Discover Novel, Selective and Original Inhibitors, BAP Project No: 09B3336002, Research Scientist, 2009-2012.
  •  Design and synthesis new indole derivatives as anti-cancer agents, The Institute of Scientific and Technical Research of Turkey, SBAG-HD-141, 106S127, Research Scientist, 2006-2007.
  • PUBLICATIONS

    1. Zühal Kilic-Kurt, Filiz Bakar and Süreyya Ölgen, Synthesis, Biological, and Computational Evaluation of Novel 1,3,5-Substituted Indolin-2-One Derivatives as Inhibitors of Src Tyrosine Kinase, Archiv der Pharmazie, DOI: 10.1002/ardp.201500109, 2015.

    2. ZühalKilic-Kurt, ArzuOnay-Besikci, SüreyyaÖlgen, Synthesis, Biological and Computational Evaluation of Novel Oxindole Derivatives as Inhibitors of Src Family Kinases, Letters in Drug Design & Discovery, 10 (8): 713-718, 2013.

    3. SüreyyaÖlgen, Andreas Gratz, Zühal Kılıç Kurt and Joachim Jose, N-Substituted Indole-2 and 3-Carboxamide Derivatives as Inhibitors of Human Protein Kinase CK2: In Vitro Assay and Molecular Modelling Study, Acta Chimica Slovenica, 60: 628-635, 2013.

    4. Z. Kılıç Kurt, D. Aydın, Y. G. İsgör, B. S. İsgör and S. Olgen, Synthesis and Biological Study of Novel Indole-3-Imine-2-on Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors, Letters in Drug Design & Discovery, 2013, 10: 19-26.

    5. Belgin S. İşgör, Zühal Kılıç-Kurt, Yasemin G. İşgör, SüreyyaÖlgen, Indole derivatives as Src family kinase and glutathione S-transferase inhibitors: evaluation of their

    selectivity and drug resistance properties, Turk J. Pharm. Sci., 9(2): 151-160, 2012.

    6. S.Olgen, A. Kaessler, Z. Kilic Kurt, J. Jose. Structure-Activity Evaluation of N-benzyl-5-substituted Indole-3-imine Derivatives and their Amine Congeners as Bovine Testicular Hyaluronidase (BHT) Inhibitor, Letters in Drug Design and Discovery, 2011, 8 (8): 685-690.

    7. Olgen S, Kılıç-Kurt Z, Sener F, Işgör YG, Coban T., Evaluation of Novel Aminomethylindole Derivatives as Src Kinase Inhibitors and Antioxidant agents, Chemotherapy, 2011, 57 (1): 1-6.

    8. Kiliç Z, Sener F, Işgör YG, Coban T, Olgen S., N-Substituted Indole-3-Imine Derivatives and Their Amine Congeners: Antioxidant and Src Kinase Inhibitory Effects, Z. Naturforschung C, 2010, 65 (5-6): 347-354.

    9. Olgen S, Kaessler A, Kiliç-Kurt Z, Jose J., Investigation of AminomethylIndole Derivatives as Hyaluronidase Inhibitors, Z. Naturforschung C, 2010,65 (7-8), 445-450.

    10. Zuhal Kılıç, Yasemin Gülgün Işgör and Süreyya Ölgen, Evaluation of new indole and bromoindole derivatives as pp60(c-Src) tyrosine kinase inhibitors. Chemical biology & drug design, 2009, 74(4):397-404.

    11. Zuhal Kılıç, Yasemin Gülgün İşgör and Süreyya Ölgen, Synthesis and pp60c-Src tyrosine kinase inhibitory activities of novel indole-3-imine and amine derivatives substituted at N1 and C5. Archiv der Pharmazie, 2009, 342(6):333-43.

    12. Isgör YG, Kiliç Z, Olgen S, Novel aminomethylindole derivatives as inhibitors of pp60c-Src tyrosine kinase: synthesis and biological activity, Chemical biology & drug design, 2008, 72(6):599-604.

    13. Süreyya Ölgen, Zühal Kılıç, Ahmet O. Ada, TülayÇoban, Synthesis and Evaluation of Novel Indole N-H and N- Substituted Indole-2 and 3-Carboxamide Derivatives as Possible Antioxidant Agents, Journal of Enzyme Inhibition and Medicinal Chemistry. 2007 22(4): 457-62.

    14. SüreyyaÖlgen, Zühal Kılıç, Ahmet O. Ada, TülayÇoban, Synthesis and Antioxidant Properties of Novel N-H and N-Substituted Propanamide Derivatives, Arch.Pharm.Chem.Life Sci. 2007, 340: 140-146.

    PRESENTATIONS

    1. Z. Kılıç-Kurt, S. Ölgen. Molecular Docking Studies of Novel Indolin-2-one Derivatives as VEGFR-2 Kinase. 11th International Symposium on Pharmaceutical Sciences, June 09-12, 2015, Ankara, TURKEY.

    2. Zühal Kilic-Kurt, Filiz Bakar, and Süreyya Ölgen. Molecular Docking and Biological Evaluation of Some Indole Derivatives as Inhibitors of Gelatinases MMP-2 and MMP-9. “3rd International Bahçeşehir University (BAU) Drug Design Congress”, October 01-03, 2015, İstanbul, TURKEY.

    3. T.G. Altuntas, N. Yılmaz, T. Çoban, Z. Kılıc Kurt, S. Ölgen, Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties, 11th International Symposium on Pharmaceutical Sciences, June 09-12, 2015, Ankara,

    TURKEY.

    4. T.G. Altuntas, A.Baydar, Z. Kılıc Kurt. Synthesis of 4-N-Substituted Piperazine Derivatives ContainingIndole-2-Carboxylic Acid, 11th International Symposium on Pharmaceutical Sciences, June 09-12, 2015, Ankara, TURKEY.

    5. Zühal Kilic-Kurt, Filiz Bakar and Süreyya Ölgen. Novel Indolin-2-one Derivatives as c-SrcTyrosineKinaseInhibitors: Synthesis, Biological Evaluation andMolecularDockingStudy. 4th International Meeting on Pharmacy&PharmaceuticalSciences (IMPPS-4), 18-21 Eylül, 2014, İstanbul, Turkey.

    6. Zühal Kilic-Kurt, Filiz Bakar and Süreyya Ölgen. Synthesis, Biological Activity andMolecularDockingStudies of Novel 3-(Substituted-benzylidene)-5-(4-fluorophenyl)indolin-2-one Derivatives as Inhibitors of c-SrcTyrosineKinase. 4th International Meeting on Pharmacy&PharmaceuticalSciences (IMPPS-4), 18-21 Eylül, 2014, Istanbul, Turkey.

    7. ZühalKilic-Kurt, ArzuOnay-Besikci, and SüreyyaÖlgen, Synthesis, Biological and Computational Evaluation of Novel 1,3,5-Substituted Indolin-2-one Derivatives as Inhibitors of Src Family Kinases, 7th Eurasian Meeting On Heterocyclic Chemistry, June 17-21, 2012, Istanbul, TURKEY.

    8. Zühal Kilic-Kurt, Arzu Onay-Besikci, and Süreyya Ölgen, Sythesis, Biological and Computational Evaluation of Novel N-(3-Substituted-benzylidene-2-oxoindolin-5-yl) acetamide Derivatives As Inhibitors of c-Src Tyrosine Kinase, 10th International Symposium on Pharmaceutical Sciences, June 26-29, 2012, Ankara, TURKEY.

    9. Sebla Dinçer, Merve Yalçın, Zühal Kılıç-Kurt, Süreyya Ölgen, Computational Evaluation of Tetrahalobenzimidazoles As Inhibitors of Casein Kinase 2, 10th International Symposium on Pharmaceutical Sciences, June 26-29, 2012, Ankara, TURKEY.

    10. SeblaDinçer, Zühal Kılıç-Kurt, Jale Buhara, Süreyya Ölgen, Sythesis and Computational Evaluation of Some Azonaphtol Benzimidazoles As Inhibitors of c-Src Kinase, 10th International Symposium on Pharmaceutical Sciences, June 26-29, 2012, Ankara, TURKEY.

    11. Z. K. Kurt, and S. Ölgen, Synthesis of Novel Oxindole Derivatives as Inhibitors of c-Src Tyrosine Kinase, 4th BBBB-Bled International Conference on Pharmaceutical Sciences New Trends in Drug Discovery, Delivery Systems and Laboratory Diagnostic, 29th September-1st October, 2011, Bled, Slovenia. (Eur. J. Pharm. Sci., 2011, 44, suppl.1, 189).

    12. Belgin S. Isgor, Yasemin G. Isgor, Zühal Kılıc-Kurt, Süreyya Ölgen, The Effect of novel pp60c-src Inhibitors on MammalianGlutathione S-Transferase Activity, Division of Medicinal Chemistry Scientific Abstracts for the 240 th National ACS Meeting and Exposition, August 22-26, 2010, Boston, MA. (ABSTR PAP AM CHEM, S 453-Med- SCI Core Index).

    13. Zühal Kılıç-Kurt,Yasemin G. Isgor, Belgin S. Isgor, Süreyya Ölgen, The Effect of Novel Indole Derivatives As Inhibitors of Src Kinase and Mammalian Glutathione S-Transferase, IMMPC-ISPC Joint Meeting, September 30-October 2, 2010, Ankara, Turkey

    14. Z. Kılıç, F. Şener, Y. G. İşgör, T. Çoban, S. Ölgen, Investigating Antioxidant and Src

    Kinase Inhibitory Effects of Aminomethylindole Derivatives, 1st Turkish-Russian Joint Meeting On Organic and Medicinal Chemistry, 14-17 October, 2009, Antalya, Türkiye.

    15. Z. Kılıç, A. Kaeßler, J. Jose, S. Ölgen, Investigaton The Hyaluronidase İnhibitory Activity of Aminomethyl Indole Derivatives, 1st Turkish-Russian Joint Meeting On Organic and Medicinal Chemistry, 14-17 October, 2009, Antalya, Turkey.

    16. Z. Kılıç,A. Kaeßler, J. Jose, S.Ölgen, Evaluation of New N- C3 and C5 Substituted Indole Derivatives as Hyaluronidase Inhibitors, 1st Turkish-Russian Joint Meeting On Organic and Medicinal Chemistry, 14-17 October, 2009, Antalya, Turkey. (Oral presentation)

    17. ZühalKılıç, Yasemin G. İşgör, Süreyya Ölgen, Evaluation of New Indole and Bromoindole Derivatives as pp60c-Src Tyrosine Kinase Inhibitors, International Symposium on Drug Research and Development "From Chemistry to Medicine" & Educational Fair On "GLP and Laboratory Safety: New Approaches", May 04-07, 2009, Ankara, TURKEY.

    18. Zühal Kılıç, Fatma Şener, Tülay Çoban, Süreyya Ölgen, Investigating Antioxidant Effects of Src Kinase Inhibitors N-Substituted Indole-3-Imine and Amine Derivatives, ISOPS-9 (9th International Symposium on Pharmaceutical Sciences), June 23-26, 2009, Ankara, TURKEY.

    19. Zühal Kılıç, Yasemin G. İşgör, Süreyya Ölgen, Synthesis of Novel 1,3,5-Trisubstituted indoledeivatives as inhibitors PP60C-SRC Tyrosine Kinase, ESOC (16th European Symposium on Organic Chemistry), July 12-16, 2009, Prague.

    20. Zühal Kılıç, Süreyya Ölgen, Synthesis and Antioxidant Properties of Novel N-Substitued Indole-Carboxamide, Acetamide and Propionamide Derivatives, ISMC (XIX.th International Symposium on Medicinal Chemistry), August 29-September 2, Istanbul, Turkey. (Drugs of the Future (SCI), Volume 31, Suppl. A, August 2006).