PROF.DR. BELMA KONUKLUGİL    
Adı : BELMA
Soyadı : KONUKLUGİL
E-posta : konuklug@pharmacy.ankara.edu.tr
Tel : 203 30 92
Ünvan : PROF.DR.
Birim : ECZACILIK FAKÜLTESİ
Bölüm : ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ
Kişisel Akademik Bilgiler

Adı:                            Belma

Soyadı:                       Konuklugil

Adres:                        Ankara Üniversitesi

                                   Eczacılık Fakültesi

                                   Farmakognozi Anabilim Dalı

                                   Tandoğan,Ankara,06100

E-posta:                     belma.konuklugil@gmail.com

Tel:                             312-2033092

 

Eğitim:           

Lisans:                       Ankara Üniversitesi, Eczacılık Fakültesi

Yüksek Lisans:         Ankara Üniversitesi, Eczacılık Fakültesi, Farmakognozi

                                   Anabilim Dalı

Doktora:                    University of Nottingham, School of Pharmacy.  –İngiltere

Kazanılan Burslar:

1995 July- October  DFG - Heinrich Heine-Universität, Institut für Entwicklungs- & Molekularbiologie der Pflanzen,Düsseldorf  University, Molecular Biologie.(Almanya).

    1996 -  British Council - Lougbrough University Medicinal and Chemistry Department

                 ( İngiltere)

 

1998-  Nato B2  -  Heinrich Heine-Universität, Institut für Entwicklungs- & Molekularbiologie 

              der Pflanzen, (Almanya).

1999 -DAAD Heinrich Heine-Universität, Institut für Entwicklungs- & Molekularbiologie der 

             Pflanzen, (Almanya). 

2014 DAAD   Pharmaceutical Biology in Düsseldorf University (Almanya). 


Uluslararası ilişkiler

Prof. Peter Proksch, Institut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf, Germany )of the Sponge Group at the University of Duesseldorf

Prof. Anake Kijjoa,Chemistry of the Biomedical Sciences Institute of Abel Salazar (ICBAS), University of Porto, Portugal

Dr. RuAngelie Edrada-Ebel Head, Natural Products Metabolomics Research Group Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyd, England

Ass. Prof.Dr. Yohei Sanasai- Laboratory of Molecular Pharmacognosy,Division of Pharmaceutical Sciences,Graduate School of Medical Science,Kanazawa University,Kakuma-machi, Kanazawa, Ishikawa,Japan

Dr. Moritz Müller, Research Fellow, Centre for Ocean Engineering, Science and Technology
Adjunct Research Fellow, Faculty of Science, Engineering and Technology, Swinburne University of Technology Sarawak Campus (SUTS) Malesia

Çalışma Alanları:

 uçucu yağlar, 

 Flavonoitler, Lİgnanlar 

  Bitki doku kültürü 

*Deniz kaynaklı bioaktif maddeler

*Deniz kaynaklı mantarlardan bioaktif maddeler

*ülkemiz için çok yeni bir konu, ben ve ekibim bu konuda çalışan ilk kişileriz.Projeler

1-      Bitirilen projeler

a-      Ulusal ve yöneticisi olduğum projeler

1-“Türkiyetede yetişen bitki türlerinden doku kültürü yolu ile podofilotoksin eldesi”   DPT Projesi (2002-2005) 2001-K-120-240

2- “Doku kültürü yolu ile podofilotoksin ve rosmarinik asit eldesi  Ankara Üniversitesi Biyoteknoloji Enstitüsü” (2001-2004)2002-K-120-130-2

3-“Doku Kültürü Yoluyla Podofilotoksin ve Rosmarinik Asit Eldesi” Ankara Üniversitesi Biyoteknoloji Enstitüsü Araştırma Projesi 2001-K-120-240)

 4- “Linum flavum ssp. scabrinerve Kallus ve Süspansiyon Kültürü ile Podofilotoksin eldesi” Ankara Üniversitesi Biyoteknoloji Enstitüsü Projesi 2001K 120-240( 149)

5- “Linum olypicum Bitkisi Üzerinde Ariltetralin ve diğer grub Lignan bileşiklerinin  Araştırılması”.

6-Ankara Üniversitesi Bilimsel araştırma Projesi. 2002K-08-03BAP (Hızlandırılmış Destek Projesi):  Türkiye’de yetişen Linum arboreum üzerinde Farmakognozik araştırmalar (2018-2019)

 

  b- Uluslararası ve yönetici olduğum projeler

1-Almanya(Jülich)-TÜBİTAK-“Türkiyede yetişen Linum türlerinden bitki doku kültürü ile ariltetralin lignan  eldesi”  Almanya(Jülich)-TÜBİTAK(2000- 2005)

2- “Türkiye denizlerinde yetişen süngelerdeki  ve süngerlerde bulunan mantarlardaki bioaktif doğal ürünler”SBAG-Julich (104S409)( 2006-2009.
3-EU project Belma Konuklugil, Russel Kerr, Peter Proksch, Bingui Wang ,”Bioactive compounds from Turkish marine macro organism and associated fungi for EU industries”  BACT 295226, 2013-  Coordinator

4-Tübitak –CNR (Italy) project  Chemical and ecological study of the Turkish coasts benthic invertebrates,   Coordinator, 2014-2016

5- Tübitak-BMBF( German) project- Bioactive metabolies from some Turkish Marine Fungi Coordinator, 2014-2017

6- Mevlana project (China) Secondary metabolites of marine fungi  2016-2019 Coordinator

Devam eden projeler

Tübitak project (Araştırmacı) "Phytochemical investigation on bioactive compounds fromTurkish macroalge" 2018-2020

T.C Bilim ve Sanayi Bakanlığı (Araştırmacı) "Secondary metabolites from Antarctic marine derived fungi and drug development "2018-2019.

 1.      Konuklugil, B., “Lignans from Linum flavum. var.compactum,” , Biochemical Systematics and Ecology, 25(1) 75, 1997.

2.      Bucar,  F., Ninov, S., Ionkova, I., Kartnig,T., Schubert-Zsilavecz, M., Asenov, I. and Konuklugil, B., “Flavonoids from Phlomis nissolii,” Phytochemistry, 48(3), 573-575, 1998.

3.      Konuklugil, B., “Arylteralin lignans from Linum catharticum L.,”Biochemical Systematics and Ecology, 26, 795-796, 1998.

4.      Konuklugil, B., Schmidt, T.J and Alfermann, A. W., “ Accumulation of aryltetraline lactone lignans in cell suspension cultures of Linum nodiflorum,” Planta Medica, 65, 587, 1999.

5.      Konuklugil, B., Schmidt, T. J., and Alfermann, A. W., “Accumulation of lignans in suspension cultures of Linum mucronatum ssp.armenum(Bordz.) Davis,” Z. Naturfosch. 56c: 1164-1165, 2001.

6.      Saygı.Ş, Konuklugil,B., Kutsal,O., Uzbay,T., Deniz,G., and Gören,Z., “Assesment of therapeutic effect of Inula  heterolepsis Boiss in alcoholic rats,” Ptytotherapy Research, 17, 683-687, 2003.

7.      Koulman, A., and Konuklugil, B.,  “Lignan profile of Linum meletonis,”Biochemical Systematics and Ecology,Vol.32, 91-93, 2004.

8.      Kartal, M., Konuklugil, B., Alfermann, A.W., and Indrayanto,G.,“Comparison of different extraction methods for the determination of   podophyllotoxin and  6-methoxypodophyllotoxin on Linum species,” Journal of Pharmaceutical and Biomedical     Analysis, 35, 441-447, 2004.

9.      Koulman, A., Konuklugil,B., Evren, H.,“Aryltetralin lignans from Linum mucronatum Bertol ssp. mucronatum, ”  Chemistry of  Natural Compounds, 41, (1) 30-31, 2005.

10.  Çoban,T., Konuklugil, B., “Free  radical scavering activity of Linum arboreum  L.” Pharmaceutical Biology, 43(4) 370-372, 2005

11.  Konuklugil, B., Aryltetralin Lignans from Linum cariense Boiss., Chemistry of  Natural Compounds 41, 3,306,-308, 2005

12.  Konuklugil, B., and Bahadir Ö., “Phenylpropanoid glycosides from Linum olypicum  (Linaceae) Turkish Journal of Chemistry,  28,741-744, 2004.

13.  Konuklugil, B., Fuss,E., and Alfermann, A. W., “Isolation of the Lignan 6- Methoxypodophyllotoxin from Linum boissieri and Biosynthesis of Lignans in this Species” Pharmaceutical Biology, 43, 9, 737-739, 2005.

14.  Öztürk N., Bozan B., Konuklugil B., “Antioxidant and free radical scavenging activities of Linum olypicum extracts” Anadolu University Journal of Sciences and technology 7,(1) 239-45,2006.

15.  İ. Orhan, M. Kartal, Q. Naz, G. Yılmaz, Y. Kan, B. Konuklugil, B. Şener, M.I. Choudhary. “Antioxidant and anticholinesterase evaluation of selected Turkish Salvia Species” Food Chemistry, 103, 1247-1254, 2007.

16.  S.Aslan, M,Fırat and B.Konuklugil., Essential oil of Cylotrichium longiflorum leblebici,  Chemistry of Natural Compounds, 6, 601-602,2007.

17.  B.Konuklugil, Ionkova,I., N, Vasılev, T.J. Schmidt, J. Windhövel., E. Fuss., A.W.Alfermann., “Lignans from Linum species of Section Syllinum nad Linum”Natural Products Research, 21(1) 1-6,2007.

18.  Y. Kan., A. Gökbulut., M. Kartal., B. Konuklugil., “Development and validation of a LC method fort he analysis of phenolic acid in Türkish Salvia species” Chromatographia,66,147-152,2007.

19.  B. Ozçelık, İ. Orhan, M. Kartal, B. Konuklugil, T. Karaoglu: In vitro testing of antiviral, antibacterial, antifungal effects and cytotoxicity of selected Turkish Phlomis species, Acta Alimentaria, 2010

20.  I. Orhan, M. Kartal, Q. Naz, G. Yilmaz, Y. Kan, B. Konuklugil, B. Şener, M.I. Choudhary “Antioxidant and anticholinesterase  evaluation of selected Turkish Salvia species” Food Chemistry, 103, 1247-1254, 2007.

21.  Kan Y., Gökbulut A., Kartal M., Konuklugil B., Yilmaz G.,”Development and validation of a LC method for the analysis of phenolic acids in Türkish Salvia species” Chromatographia, 66,147-152, 2007.

22.  Watjen W., Putz,A., Cholou,Y., Kampkötter,A., Totzke,F., Kubbutat,H., Proksch,P., Konuklugil,B., “Hexa-hepta-nonaprenylhydroquinone isolated from Marine sponge Sarcotragus muscarum ve Ircinia fasciculata   induce apoptosis in Hct 116 cells” Pharmacy and Pharmacology 61,919-924, 2009.

23.  S. Aslan H. Evren, B. Konuklugil I. Turkoglu and M. Kartal . “Essential oil composition of Achillea teretifolia from Turkey”, Chemistry of Natural Compounds.2, 230-23, 2009.

24.  B. Ozçelık, İ. Orhan, M. Kartal, B. Konuklugil, T. Karaoglu. “In vitro testing of antiviral,   antibacterial   antifungal effects and cytotoxicity of selected Turkish Phlomis species”, Acta Alimentaria, 39, 109-115, 2010,

25.  Nihal Aktaş, Bülent Gözcelioğlu, WEn-Han, Lin, Belma Konuklugil  “Avarone  and avarol from the marine sponge Dysidea avara Schmidt from  Marmara coast of Turkey” Fabad 35(3), 119-123, 2010.

26.  Bülent Gözcelioğlu, Rob Van Soest, Peter Proksch, Belma Konuklugil,  “Contrubition to the knowledge of the Demosponlae ( Porifera) fauna of Turkey”, Zollogy in the Middle Esat 54, 149-152,2011.

27.  İlkay Erdoğan, Berrin Özçelik, Belma Konuklugil, Annika Putz,Ülkü Gökçen Kaban and  Peter Proksch   “Bioactivity screening of the selected Turkish marine sponges and three compounds from Agelas oroides”, Records of Natural Products 6:4356-367 2012.

28.  Bousetla A, Konuklugil B, Bouacida S, Zellagui A, Rhouati S, Akkal S “Phytochemical study of Algerian Foeniculum vulgare Mill (Apiaceae)”  Der Pharmacia Lettre, 5 (5), 305-307, 2013.

29.  Bousetla A, M. Kürkçüoğlu, Konuklugil B, H.K.C. Başer, Rouati,S, “Composition of esential oil from Bunium incrassatum from Algeria” Chemistry of  Natural  Compounds, 50(4) 2014.

30.  Aktaş N, Genç Y, Gözcelioğlu B, Konuklugil , B  and  Ş, Harput “ Radical Scavenging Activities of  Different Marine Sponge Extracts Mediterranean,  Coast”,  Records of Natural      Products  Vol. 7: 2, 96-104, 2013.

31.  Aktaş N, Gözcelioğlu B, Konuklugil B, “Detection of Some Secondary Metabolites from Turkish Marine Sponges Collected in Kemer”, Fabad  36,129-136, 2011(print 2013)

32.  AktaşN, Gözcelioğlu B, , Lin W, Konuklugil B, “ Avarone  and avarol from the marine sponge Dysidea avara Schmidt from  Marmara coast of Turkey” Fabad, 35(3), 119-123, 2010.( print 2013)

33.  Gözcelioğlu B, Konuklugil B,  Qualitative Detection of Some Secondary Metabolites from Three Turkish Marine  Sponges, Fabad, 37,( 2), 2015.

34.  Gao Shang, Li-Hia-Hua, Belma Konuklugil, Lıu Hong-bing, “Study on Bromopyrrole alkaloids from marine sponges Axinalla verrucosa and their immunogical activity in vitro” Chinese Journal of Marine drugs, 34(2) 1-4, 2015.

35.  Bülent  Gözcelioğlu, Rob VAN SOEST, Belinda ALVAREZ, Belma KONUKLUGİL, “New species of sponges (Porifera, Demospongiae) from Turkey  coast”, Turkish Journal of  Zoology, 39,555-559,2015.

36.  Gao Shang, Li-Hia-Hua, Belma Konuklugil, Lıu Hong-bing, “Study on Bromopyrrole alkaloids from marine sponges Axinalla verrucosa and their immunogical activity in vitro” Chinese Journal of Marine drugs, 34(2) 1-4, 2015.

37.  Huiqin Chen  , Nihal Aktas, Belma Konuklugil  , Attila Mándi  , Georgios Daletosa , Wenhan Lin  , Haofu Dai  , Tibor Kurtán  , Peter Proksch “ A new fusarielin analogue from Penicillium sp. isolated from the Mediterranean sponge Ircinia oros” Tetrahedron Letters 56,  5317–5320 2015.

38.  Ling-Hong Meng, Hui-Qin Chen, Imke Form, Belma Konuklugil, Peter Proksch and Bin-Gui Wan, , “New Chromone, Isocoumarin, and Indole Alkaloid Derivatives from three Sponge-derived Fungal Strains”. Natural Product Communications, Vol. 1,No. 9, 1293 – 1296, 2016.

39.  Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp. Shuai Liu, Haofu Dai, Belma Konuklugil, Raha S. Orfali,Wenhan Lin,Rainer Kalscheuer, Zhen Liu, Peter Proksch, “Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp. ” Phytochemistry Letters, Vol. 18,187–191,2016.

40.  Eyup Dogan, Ozge Demir, Melek Sertdemir, Mehmet Ali Saraclı & Belma Konuklugil,  “Screening of the Selected Marine Sponges from the Coasts of Turkey for Antimicrobial Activity" Indian Journal of Geo-Marine Science. 47 (06) 1193-1198,2018.

41.  Junjun Meng, Wei Cheng, Hajar Heydari , Bin Wang, Kui Zhu, Belma Konuklugil  and Wenhan Lin. Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum. Marine drugs16, 226, . 2018.

 

42.  Hajar Heydari, Bulent Gozceliogl, Belma Konuklugil. Bioactivity screening of Dictyonella incisa from Turkey. Kafkas Universitesi Veteriner Fakültesi Dergisi. 24(3): 479-482, 2018.

 

43.  Belma Konuklugil, Hajar Heydari, Yasin Genç, Ufuk Özgen. Bioactivity screening of some marine species from Turkey's coasts. Farmacia.2018, 66(2):342-346, 2018.

 

44.  Özge Demir, Hajar Heydari, Bülent Gozcelioglu and Belma Konuklugil, Determination and Quantification of Avarol in Dysidia Avara by HPLC-DAD, European Journal of Pharmaceutical and Medical Research,5(03), 118-121.2018.

 

45.  Belma Konuklugil, Melek Sertdemir, Hajar Heydari, Aslı Koç. Isolation and bioactivities screening of Turkish Microcosmus vulgaris. Turkish Journal of Fisheries and Aquatic Sciences Vol: 19 (the year 2019).

 

46.  Hajar Heydari, Bulent Gozcelioglu, Belma Konuklugil. Turkish marine sponges secondary metabolites and bioactivity. Accepted by Records of Natural Product. (accepted)

 

47.  Belma Konuklugil, Hajar Heydari. Bioactive Metabolites from Turkish Marine Invertebrates and Associated Fungi. Book Chapter. Springer (accepted)

 

48.  Jin Caoa,Xiao-Ming Lia, Ling-Hong Menga, Belma Konuklugil, Xin Lia, Hong-Lei Lia,

Bin-Gui Wanga, Isolation and characterization of three pairs of indolediketopiperazine enantiomers containing infrequent N-methoxy substitution from the marine algal-derived endophytic fungus Acrostalagmus luteoalbus TK-43, Bioorganic Chemistry

90, 1-7, 2019,

 https://doi.org/10.1016/j.bioorg.2019.103030



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